BR112018073794A2 - segmento genômico, cdna, vetor, célula hospedeira, partícula, método de produção de um segmento genômico, método de geração da partícula, vacina, composição farmacêutica - Google Patents

segmento genômico, cdna, vetor, célula hospedeira, partícula, método de produção de um segmento genômico, método de geração da partícula, vacina, composição farmacêutica

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Publication number
BR112018073794A2
BR112018073794A2 BR112018073794-1A BR112018073794A BR112018073794A2 BR 112018073794 A2 BR112018073794 A2 BR 112018073794A2 BR 112018073794 A BR112018073794 A BR 112018073794A BR 112018073794 A2 BR112018073794 A2 BR 112018073794A2
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BR
Brazil
Prior art keywords
genomic segment
particle
segment
pichinde virus
vaccine
Prior art date
Application number
BR112018073794-1A
Other languages
English (en)
Inventor
Bonilla Weldi
David Pinschewer Daniel
Orlinger Klaus
Original Assignee
Hookipa Biotech Gmbh
Universität Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hookipa Biotech Gmbh, Universität Basel filed Critical Hookipa Biotech Gmbh
Publication of BR112018073794A2 publication Critical patent/BR112018073794A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/06—Quantitative determination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10041—Use of virus, viral particle or viral elements as a vector
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/10011—Arenaviridae
    • C12N2760/10051—Methods of production or purification of viral material
    • C12N2760/10052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
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  • Mycology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract

o presente pedido de patente refere-se um vírus pichinde com rearranjos das fases de leitura aberta (orf) em seus genomas. especificamente, a presente invenção descreve um segmento genômico modificado do vírus pichinde, em que o segmento genômico do vírus pichinde é construído para carregar uma orf viral em uma posição diferente da posição da orf do tipo selvagem. além disso, são também descritas partículas trissegmentadas do vírus pichinde compreendendo um segmento l e dois segmentos s ou dois segmentos l e um segmento s. o vírus pichinde, aqui descrito, pode ser adequado para vacinas e/ou o tratamento de doenças e/ou para o uso em imunoterapias.
BR112018073794-1A 2016-05-18 2017-05-17 segmento genômico, cdna, vetor, célula hospedeira, partícula, método de produção de um segmento genômico, método de geração da partícula, vacina, composição farmacêutica BR112018073794A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662338400P 2016-05-18 2016-05-18
US62/338,400 2016-05-18
PCT/EP2017/061865 WO2017198726A1 (en) 2016-05-18 2017-05-17 Tri-segmented pichinde viruses as vaccine vectors

Publications (1)

Publication Number Publication Date
BR112018073794A2 true BR112018073794A2 (pt) 2019-02-26

Family

ID=58800799

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018073794-1A BR112018073794A2 (pt) 2016-05-18 2017-05-17 segmento genômico, cdna, vetor, célula hospedeira, partícula, método de produção de um segmento genômico, método de geração da partícula, vacina, composição farmacêutica

Country Status (13)

Country Link
US (2) US20190135875A1 (pt)
EP (1) EP3458593A1 (pt)
JP (2) JP7254018B2 (pt)
KR (2) KR20240095333A (pt)
CN (2) CN117486979A (pt)
AU (2) AU2017266738B2 (pt)
BR (1) BR112018073794A2 (pt)
CA (1) CA3023599A1 (pt)
EA (1) EA201892648A1 (pt)
IL (2) IL262963B1 (pt)
MX (2) MX2018013956A (pt)
SG (1) SG11201810048VA (pt)
WO (1) WO2017198726A1 (pt)

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CA3202466A1 (en) 2021-01-14 2022-07-21 Jiani LI Hiv vaccines and methods of using
IL305965A (en) 2021-03-23 2023-11-01 Hookipa Biotech Gmbh ARENAVIRUSES USED IN PROSTATE CANCER TREATMENTS
KR20240006683A (ko) 2021-05-13 2024-01-15 길리애드 사이언시즈, 인코포레이티드 TLR8 조절 화합물과 항-HBV siRNA 치료제의 조합물
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IL312429A (en) * 2021-11-08 2024-06-01 Hookipa Biotech Gmbh Tailored RNAV Particles Expressing Mutant KRAS, a Mutated Cancer Executive Gene, or Tumor-Associated Antigen as Cancer Immunotherapy
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Also Published As

Publication number Publication date
KR20240095333A (ko) 2024-06-25
CN109804074A (zh) 2019-05-24
US20220289797A1 (en) 2022-09-15
EP3458593A1 (en) 2019-03-27
AU2023285703A1 (en) 2024-01-18
MX2024005757A (es) 2024-05-24
US20190135875A1 (en) 2019-05-09
CN109804074B (zh) 2023-10-10
MX2018013956A (es) 2019-07-04
IL314272A (en) 2024-09-01
SG11201810048VA (en) 2018-12-28
IL262963B1 (en) 2024-09-01
WO2017198726A1 (en) 2017-11-23
JP2023012463A (ja) 2023-01-25
JP7254018B2 (ja) 2023-04-07
AU2017266738A1 (en) 2018-11-29
JP7547433B2 (ja) 2024-09-09
CA3023599A1 (en) 2017-11-23
CN117486979A (zh) 2024-02-02
JP2019516410A (ja) 2019-06-20
KR20190016032A (ko) 2019-02-15
AU2017266738B2 (en) 2023-10-12
IL262963A (en) 2018-12-31
EA201892648A1 (ru) 2019-06-28
KR102671785B1 (ko) 2024-06-04

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B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]