BR112016026651A2 - evolução de vesículas semelhantes a vírus de alta titulação para aplicações de vacina - Google Patents

evolução de vesículas semelhantes a vírus de alta titulação para aplicações de vacina

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Publication number
BR112016026651A2
BR112016026651A2 BR112016026651A BR112016026651A BR112016026651A2 BR 112016026651 A2 BR112016026651 A2 BR 112016026651A2 BR 112016026651 A BR112016026651 A BR 112016026651A BR 112016026651 A BR112016026651 A BR 112016026651A BR 112016026651 A2 BR112016026651 A2 BR 112016026651A2
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Brazil
Prior art keywords
vesicles
vaccine
methods
evolution
titer
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BR112016026651A
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English (en)
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Rose John
Rose Nina
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Univ Yale
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Publication of BR112016026651A2 publication Critical patent/BR112016026651A2/pt

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Abstract

resumo ?evolução de vesículas semelhantes a vírus de alta titulação para aplicações de vacina? a presente invenção se refere à descoberta de um vetor de vírus híbrido de alta titulação que dá origem a vesículas semelhantes a vírus de alta titulação (vlvs) que podem ser usadas como uma vacina. a invenção inclui composições e métodos de geração de uma vacina de vetor de vírus híbrido evoluído e seleção de vlvs de alta titulação, métodos de tratamento e/ou prevenção ou imunização contra, uma doença ou distúrbio específico, e métodos de indução de uma resposta imune de células t e células b de memória em um sujeito administrado com a composição de vlv assim produzida. além disso, a invenção abrange uma composição farmacêutica para vacinação de um sujeito, bem como um sistema de expressão de proteína de alta titulação.
BR112016026651A 2014-05-16 2015-05-11 evolução de vesículas semelhantes a vírus de alta titulação para aplicações de vacina BR112016026651A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461994161P 2014-05-16 2014-05-16
PCT/US2015/030102 WO2015175382A1 (en) 2014-05-16 2015-05-11 Evolution of high-titer virus-like vesicles for vaccine applications

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BR112016026651A2 true BR112016026651A2 (pt) 2017-10-31

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US (1) US10435712B2 (pt)
EP (1) EP3143145A4 (pt)
JP (1) JP2017515509A (pt)
CN (1) CN106459997A (pt)
AU (1) AU2015259472A1 (pt)
BR (1) BR112016026651A2 (pt)
CA (1) CA2948364A1 (pt)
WO (1) WO2015175382A1 (pt)

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Publication number Priority date Publication date Assignee Title
BR112016026721A2 (pt) * 2014-05-16 2017-10-31 Univ Yale vacinas com base em vesículas do tipo vírus (vlvs) para prevenir ou tratar infecção por vírus da hepatite b (hbv) crônica
CN106459997A (zh) 2014-05-16 2017-02-22 耶鲁大学 用于疫苗应用的高效价病毒样囊泡的进化
KR102011375B1 (ko) * 2017-06-30 2019-08-16 주식회사 엠디헬스케어 프로테우스 속 세균 유래 나노소포 및 이의 용도
CA3072329A1 (en) 2017-08-07 2019-02-14 The Regents Of The University Of California Platform for generating safe cell therapeutics
JP2023509966A (ja) 2020-01-10 2023-03-10 カロジェン コーポレイション 腫瘍溶解性ウイルス様小胞の組成物および使用方法
CN111560352B (zh) * 2020-06-02 2023-03-24 新疆农业大学 一种病毒样囊泡及其制备方法和应用
WO2023097652A1 (en) * 2021-12-03 2023-06-08 National Center For Nanoscience And Technology An engineered cell and application thereof
WO2024026274A2 (en) * 2022-07-26 2024-02-01 Yale University Virus-like vesicles (vlvs) based vaccines and methods of preventing, ameliorating, and/or treating covid-19 and/or hepatocellular carcinoma (hcc)

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WO2009090594A2 (en) * 2008-01-11 2009-07-23 Yale University Alphavirus based vectors
US20030099932A1 (en) 1998-05-12 2003-05-29 Lorens James B. Retroviral vectors with separation sequences
ES2170622B1 (es) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
AU2003288119B2 (en) 2002-11-21 2009-08-20 Pevion Biotech Ltd. High-efficiency fusogenic vesicles, methods of producing them, and pharmaceutical compositions containing them
WO2007047749A1 (en) * 2005-10-18 2007-04-26 Novartis Vaccines And Diagnostics Inc. Mucosal and systemic immunizations with alphavirus replicon particles
CN106459997A (zh) 2014-05-16 2017-02-22 耶鲁大学 用于疫苗应用的高效价病毒样囊泡的进化

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CA2948364A1 (en) 2015-11-19
JP2017515509A (ja) 2017-06-15
US20170051307A1 (en) 2017-02-23
US10435712B2 (en) 2019-10-08
EP3143145A1 (en) 2017-03-22
AU2015259472A1 (en) 2016-11-10
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EP3143145A4 (en) 2017-12-27

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