BR112018072783A2 - proteínas de fusão elp para liberação controlada e retardada - Google Patents

proteínas de fusão elp para liberação controlada e retardada

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Publication number
BR112018072783A2
BR112018072783A2 BR112018072783-0A BR112018072783A BR112018072783A2 BR 112018072783 A2 BR112018072783 A2 BR 112018072783A2 BR 112018072783 A BR112018072783 A BR 112018072783A BR 112018072783 A2 BR112018072783 A2 BR 112018072783A2
Authority
BR
Brazil
Prior art keywords
delayed release
controlled
fusion proteins
elp fusion
provides
Prior art date
Application number
BR112018072783-0A
Other languages
English (en)
Inventor
Jowett James
James Ballance David
Original Assignee
Phasebio Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phasebio Pharmaceuticals, Inc. filed Critical Phasebio Pharmaceuticals, Inc.
Publication of BR112018072783A2 publication Critical patent/BR112018072783A2/pt

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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/475—Growth factors; Growth regulators
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Inorganic Chemistry (AREA)
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  • Oil, Petroleum & Natural Gas (AREA)
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  • Pulmonology (AREA)

Abstract

a presente invenção fornece formulações farmacêuticas de liberação retardada e métodos para fornecer um esquema de tratamento com as formulações de liberação retardada e de longo prazo. a invenção fornece melhor farmacocinética de fármacos peptídeos e pequenas moléculas.
BR112018072783-0A 2016-05-06 2017-05-01 proteínas de fusão elp para liberação controlada e retardada BR112018072783A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662332803P 2016-05-06 2016-05-06
US62/332,803 2016-05-06
US201762442057P 2017-01-04 2017-01-04
US62/442,057 2017-01-04
PCT/US2017/030403 WO2017192449A1 (en) 2016-05-06 2017-05-01 Elp fusion proteins for controlled and sustained release

Publications (1)

Publication Number Publication Date
BR112018072783A2 true BR112018072783A2 (pt) 2019-03-12

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BR112018072783-0A BR112018072783A2 (pt) 2016-05-06 2017-05-01 proteínas de fusão elp para liberação controlada e retardada

Country Status (11)

Country Link
US (2) US20190218274A1 (pt)
EP (2) EP4043010A1 (pt)
JP (1) JP7050003B2 (pt)
KR (2) KR102646323B1 (pt)
CN (3) CN118078956A (pt)
AU (2) AU2017261216B2 (pt)
BR (1) BR112018072783A2 (pt)
CA (1) CA3021644A1 (pt)
ES (1) ES2909074T3 (pt)
MX (1) MX2018013546A (pt)
WO (1) WO2017192449A1 (pt)

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BR112018002342A2 (pt) 2015-08-04 2018-12-11 Univ Duke polímeros furtivos intrinsecamente desordenados e geneticamente modificados para entrega e métodos para uso dos mesmos
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
CN109890833A (zh) 2016-09-14 2019-06-14 杜克大学 用于递送亲水性药物的基于三嵌段多肽的纳米粒子
CN110023326A (zh) 2016-09-23 2019-07-16 杜克大学 具有lcst行为的非结构化无重复多肽
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
JP2021505620A (ja) * 2017-12-05 2021-02-18 イーレイズ・インコーポレーテッド アルギナーゼ１欠損症を治療するための方法及び組成物
WO2020028806A1 (en) * 2018-08-02 2020-02-06 Duke University Dual agonist fusion proteins
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US20220289812A1 (en) * 2019-08-09 2022-09-15 Phasebio Pharmaceuticals, Inc. Elp fusion proteins comprising parathyroid hormone for controlled and sustained release
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