BR112018072006A2 - adesivo ósseo degradável à base de poli (éster ureia) fosforilada - Google Patents

adesivo ósseo degradável à base de poli (éster ureia) fosforilada

Info

Publication number
BR112018072006A2
BR112018072006A2 BR112018072006-2A BR112018072006A BR112018072006A2 BR 112018072006 A2 BR112018072006 A2 BR 112018072006A2 BR 112018072006 A BR112018072006 A BR 112018072006A BR 112018072006 A2 BR112018072006 A2 BR 112018072006A2
Authority
BR
Brazil
Prior art keywords
bone
urea ester
poly
phosphate
adhesives
Prior art date
Application number
BR112018072006-2A
Other languages
English (en)
Inventor
Becker Matthew
Dinkar Bhagat Vrushali
Original Assignee
The University Of Akron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of Akron filed Critical The University Of Akron
Publication of BR112018072006A2 publication Critical patent/BR112018072006A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0042—Materials resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/16—Halogen-containing compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/02—Polyureas
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/04—Polyamides derived from alpha-amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/16—Halogen-containing compounds
    • C08K2003/162—Calcium, strontium or barium halides, e.g. calcium, strontium or barium chloride
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/16—Halogen-containing compounds
    • C08K2003/166—Magnesium halide, e.g. magnesium chloride
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/16—Halogen-containing compounds
    • C08K2003/168—Zinc halides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)

Abstract

em vários aspectos, a presente invenção fornece um novo degradável e reabsorvente adesivo de poli (éster ureia) à base de aminoácido funcionalizado por fosfato e métodos relacionados para sua síntese e uso. estes adesivos são formados a partir de polímeros de peu funcionalizados por fosfato e copolímeros, reticulados pelo uso de um ou mais agentes metálicos divalentes reticulantes. os adesivos de poli (éster ureia) à base de aminoácido funcionalizado por fosfato de vários modos de execução da presente invenção mostraram-se particularmente efetivos em ligar osso a osso ou metal e demonstraram forças adesivas em amostras de osso que eram significativas e comparáveis ao cimento ósseo de poli (metil metacrilato) disponível comercialmente.
BR112018072006-2A 2016-04-28 2017-04-25 adesivo ósseo degradável à base de poli (éster ureia) fosforilada BR112018072006A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662328653P 2016-04-28 2016-04-28
US62/328,653 2016-04-28
PCT/US2017/029342 WO2017189534A1 (en) 2016-04-28 2017-04-25 Phosphorylated poly(ester-urea) based degradable bone adhesives

Publications (1)

Publication Number Publication Date
BR112018072006A2 true BR112018072006A2 (pt) 2019-04-02

Family

ID=60161120

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018072006-2A BR112018072006A2 (pt) 2016-04-28 2017-04-25 adesivo ósseo degradável à base de poli (éster ureia) fosforilada

Country Status (9)

Country Link
US (1) US11103613B2 (pt)
EP (1) EP3448307B1 (pt)
JP (1) JP7006944B2 (pt)
KR (1) KR102419992B1 (pt)
CN (1) CN109561953B (pt)
AU (1) AU2017257659B2 (pt)
BR (1) BR112018072006A2 (pt)
CA (1) CA3022412A1 (pt)
WO (1) WO2017189534A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019104163A1 (en) 2017-11-21 2019-05-31 The University Of Akron Amino acid-based poly(ester urea) polymer mesh for hernia and other soft tissue applications
CA3103439A1 (en) 2018-06-11 2019-12-19 Histogenics Corporation Scaffold with adhesive for articular cartilage repair
CA3139659A1 (en) 2019-05-09 2020-11-12 The University Of Akron Antibiotic eluting poly (ester urea) films for infection control of implantable medical devices

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8765164B2 (en) 2005-10-21 2014-07-01 Kenneth W. Carpenter Poly(ester urea) polymers and methods of use
WO2011091411A2 (en) * 2010-01-25 2011-07-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Polyesters, methods of making polyesters and uses therefor
WO2012166594A1 (en) * 2011-05-27 2012-12-06 The University Of Akron Peptide-crosslinked bioactive polymeric materials
WO2013142969A1 (en) * 2012-03-28 2013-10-03 Jian Ping Gao Urethanes and ureas and processes
US10537660B2 (en) * 2013-10-29 2020-01-21 The University Of Akron Resorbable, amino acid-based poly(ester urea)s scaffold for vascular graft tissue engineering
WO2015171854A1 (en) * 2014-05-07 2015-11-12 The University Of Akron Radioopaque, iodine functionalized phenylalanine-based poly(ester urea)s
EP3171880A4 (en) * 2014-07-22 2017-12-13 The University of Akron Degradable amino acid-based poly(ester urea) copolymer adhesives

Also Published As

Publication number Publication date
CN109561953B (zh) 2021-12-21
EP3448307B1 (en) 2023-07-26
AU2017257659A1 (en) 2018-11-15
CN109561953A (zh) 2019-04-02
US11103613B2 (en) 2021-08-31
US20190167838A1 (en) 2019-06-06
JP2019520432A (ja) 2019-07-18
AU2017257659B2 (en) 2022-05-12
KR20190013781A (ko) 2019-02-11
JP7006944B2 (ja) 2022-02-10
KR102419992B1 (ko) 2022-07-14
CA3022412A1 (en) 2017-11-02
EP3448307A4 (en) 2019-12-25
EP3448307A1 (en) 2019-03-06
WO2017189534A1 (en) 2017-11-02

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2622 DE 06/04/2021.

B350 Update of information on the portal [chapter 15.35 patent gazette]