BR112018070971A2 - métodos e kits para a diagnose e estratificação de risco de pacientes com isquemia - Google Patents
métodos e kits para a diagnose e estratificação de risco de pacientes com isquemiaInfo
- Publication number
- BR112018070971A2 BR112018070971A2 BR112018070971A BR112018070971A BR112018070971A2 BR 112018070971 A2 BR112018070971 A2 BR 112018070971A2 BR 112018070971 A BR112018070971 A BR 112018070971A BR 112018070971 A BR112018070971 A BR 112018070971A BR 112018070971 A2 BR112018070971 A2 BR 112018070971A2
- Authority
- BR
- Brazil
- Prior art keywords
- ischemia
- methods
- diagnosis
- kits
- patients
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 208000028867 ischemia Diseases 0.000 title abstract 3
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000013517 stratification Methods 0.000 title 1
- 230000000302 ischemic effect Effects 0.000 abstract 4
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 230000000306 recurrent effect Effects 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/775—Apolipopeptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
- G01N2440/38—Post-translational modifications [PTMs] in chemical analysis of biological material addition of carbohydrates, e.g. glycosylation, glycation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382167.1A EP3232200A1 (en) | 2016-04-12 | 2016-04-12 | Methods and kits for the diagnosis and risk stratification of patients with ischemia |
| PCT/EP2017/058768 WO2017178521A1 (en) | 2016-04-12 | 2017-04-12 | Methods and kits for the diagnosis and risk stratification of patients with ischemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018070971A2 true BR112018070971A2 (pt) | 2019-01-29 |
Family
ID=56008566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018070971A BR112018070971A2 (pt) | 2016-04-12 | 2017-04-12 | métodos e kits para a diagnose e estratificação de risco de pacientes com isquemia |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11486884B2 (https=) |
| EP (2) | EP3232200A1 (https=) |
| JP (1) | JP7075894B2 (https=) |
| KR (1) | KR102344344B1 (https=) |
| CN (1) | CN109154620B (https=) |
| AU (1) | AU2017251355A1 (https=) |
| BR (1) | BR112018070971A2 (https=) |
| CA (1) | CA3020666A1 (https=) |
| ES (1) | ES2979390T3 (https=) |
| IL (1) | IL262245B (https=) |
| MA (1) | MA44658A (https=) |
| MX (1) | MX2018012580A (https=) |
| RU (1) | RU2750035C2 (https=) |
| SG (1) | SG11201808820QA (https=) |
| WO (1) | WO2017178521A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3870614A1 (en) * | 2018-10-23 | 2021-09-01 | GlyCardial Diagnostics, S.L. | Antibodies specific for glycosylated apoj and uses thereof |
| JP2022510403A (ja) * | 2018-12-05 | 2022-01-26 | グリカルディアル ダイアグノスティクス エセ． エレ． | 虚血傷害および虚血再灌流傷害の予防および／または治療のための方法および組成物 |
| KR102158726B1 (ko) | 2019-04-17 | 2020-09-22 | 한림대학교 산학협력단 | Itpr3 유전자 업스트림의 유전자간 영역을 포함하는 지연성 허혈 진단용 dna 메틸화 마커 조성물 |
| KR102281657B1 (ko) | 2019-12-23 | 2021-07-26 | 한림대학교 산학협력단 | 지연성 허혈 진단을 위한 cdhr5 유전자 과메틸화 마커 |
| KR102281644B1 (ko) | 2019-12-23 | 2021-07-23 | 한림대학교 산학협력단 | 지연성 허혈 진단을 위한 insr 유전자 과메틸화 마커 |
| KR102312534B1 (ko) | 2019-12-31 | 2021-10-13 | 한림대학교 산학협력단 | 뇌척수액 유래 미토콘드리아 마커를 이용한 지연성 허혈 진단 방법 |
| KR102318236B1 (ko) | 2020-02-18 | 2021-10-26 | 한림대학교 산학협력단 | 혈중 코펩틴의 농도를 이용한 지연성 뇌허혈 진단 방법 |
| KR102336507B1 (ko) | 2020-02-21 | 2021-12-06 | 한림대학교 산학협력단 | 국소뇌산소포화도를 이용한 지연성 뇌허혈 진단 방법 |
| KR102369155B1 (ko) | 2020-07-07 | 2022-02-28 | 한림대학교 산학협력단 | 근적외선 분광분석법을 이용한 지연성 뇌허혈 진단 방법 |
| KR102473348B1 (ko) | 2020-09-11 | 2022-12-05 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 kif3a 유전자 과메틸화 마커 |
| KR102473349B1 (ko) | 2020-09-11 | 2022-12-05 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 kifap3 유전자 과메틸화 마커 |
| KR102473350B1 (ko) | 2020-09-11 | 2022-12-05 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 racgap1 유전자 과메틸화 마커 |
| KR102496589B1 (ko) | 2020-09-11 | 2023-02-03 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 vhl 유전자 과메틸화 마커 |
| KR102477501B1 (ko) | 2020-09-15 | 2022-12-14 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 alb 유전자 저메틸화 마커 |
| KR102477500B1 (ko) | 2020-09-15 | 2022-12-14 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 oprm1 유전자 과메틸화 마커 |
| KR102477502B1 (ko) | 2020-09-15 | 2022-12-14 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 il5 유전자 저메틸화 마커 |
| KR102398533B1 (ko) | 2020-11-05 | 2022-05-13 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 뇌척수액 마이토파지 마커 |
| KR102470789B1 (ko) | 2020-11-05 | 2022-11-25 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 pink1 바이오마커 |
| KR102466956B1 (ko) | 2020-11-05 | 2022-11-11 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 dapk1 바이오마커 |
| KR102398534B1 (ko) | 2020-11-05 | 2022-05-13 | 한림대학교 산학협력단 | 지연성 뇌허혈 진단을 위한 bnip3l 바이오마커 |
| CN113462744B (zh) * | 2021-05-24 | 2023-06-23 | 中国药科大学 | N-乙酰葡萄糖胺作为标志物在制备诊断缺血性脑中风试剂中的应用 |
| KR102865129B1 (ko) | 2021-08-06 | 2025-09-26 | 에이치앤비지노믹스 주식회사 | 지능형 오믹스 기반 개인별 맞춤형 복잡질환 발병 위험도 정보 제공 방법 및 장치 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
| AU8483698A (en) * | 1997-07-15 | 1999-02-10 | Bioprobes, Inc. | Determining alcohol intake using sialic acid/apo j |
| US6197599B1 (en) | 1998-07-30 | 2001-03-06 | Guorong Chin | Method to detect proteins |
| US20090166224A1 (en) * | 2004-05-05 | 2009-07-02 | Ziping Yang | Multi-lectin affinity chromatography and uses thereof |
| EP2950098A1 (en) * | 2009-07-14 | 2015-12-02 | National Institute of Advanced Industrial Science and Technology | Glycan markers as measure of disease state of hepatic diseases |
| ES2364169B1 (es) | 2010-02-09 | 2012-07-10 | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (Titular al 50%) | Uso de las isoformas de apo j como biomarcadores de lesión tisular. |
| EP2400304A1 (en) * | 2010-06-22 | 2011-12-28 | Centro de Investigación Cooperativa En Biomateriales ( CIC biomaGUNE) | Method for the characterization of intermolecular interactions |
| JP2012107932A (ja) | 2010-11-16 | 2012-06-07 | Mitsubishi Chemicals Corp | Ｃｌｕｓｔｅｒｉｎ蛋白質による脳梗塞の検査方法 |
| CA2983828A1 (en) | 2015-04-30 | 2016-11-03 | Idexx Laboratories, Inc. | Specific detection of clusterin isoforms |
| CN107957498A (zh) * | 2016-10-18 | 2018-04-24 | 厦门德馨尚品医疗科技有限公司 | 一种含有载脂蛋白j的试剂盒及其在临床诊断中的应用 |
-
2016
- 2016-04-12 EP EP16382167.1A patent/EP3232200A1/en not_active Withdrawn
-
2017
- 2017-04-12 BR BR112018070971A patent/BR112018070971A2/pt not_active Application Discontinuation
- 2017-04-12 CN CN201780029342.8A patent/CN109154620B/zh not_active Expired - Fee Related
- 2017-04-12 ES ES17717159T patent/ES2979390T3/es active Active
- 2017-04-12 RU RU2018139780A patent/RU2750035C2/ru active
- 2017-04-12 EP EP17717159.2A patent/EP3443353B1/en active Active
- 2017-04-12 MA MA044658A patent/MA44658A/fr unknown
- 2017-04-12 MX MX2018012580A patent/MX2018012580A/es unknown
- 2017-04-12 JP JP2018554391A patent/JP7075894B2/ja not_active Expired - Fee Related
- 2017-04-12 KR KR1020187032609A patent/KR102344344B1/ko not_active Expired - Fee Related
- 2017-04-12 US US16/092,703 patent/US11486884B2/en active Active
- 2017-04-12 SG SG11201808820QA patent/SG11201808820QA/en unknown
- 2017-04-12 WO PCT/EP2017/058768 patent/WO2017178521A1/en not_active Ceased
- 2017-04-12 AU AU2017251355A patent/AU2017251355A1/en not_active Abandoned
- 2017-04-12 CA CA3020666A patent/CA3020666A1/en active Pending
-
2018
- 2018-10-09 IL IL262245A patent/IL262245B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MX2018012580A (es) | 2019-02-25 |
| US20190128900A1 (en) | 2019-05-02 |
| US11486884B2 (en) | 2022-11-01 |
| JP2019516966A (ja) | 2019-06-20 |
| RU2750035C2 (ru) | 2021-06-21 |
| WO2017178521A1 (en) | 2017-10-19 |
| EP3232200A1 (en) | 2017-10-18 |
| KR102344344B1 (ko) | 2021-12-28 |
| IL262245B (en) | 2021-03-25 |
| EP3443353B1 (en) | 2024-03-13 |
| IL262245A (en) | 2018-11-29 |
| RU2018139780A3 (https=) | 2020-07-24 |
| JP7075894B2 (ja) | 2022-05-26 |
| RU2018139780A (ru) | 2020-05-12 |
| ES2979390T3 (es) | 2024-09-25 |
| MA44658A (fr) | 2019-02-20 |
| CN109154620A (zh) | 2019-01-04 |
| SG11201808820QA (en) | 2018-11-29 |
| AU2017251355A1 (en) | 2018-11-08 |
| KR20190008216A (ko) | 2019-01-23 |
| CN109154620B (zh) | 2022-03-08 |
| EP3443353A1 (en) | 2019-02-20 |
| CA3020666A1 (en) | 2017-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |