BR112018016110A2 - gerador de aerossol, nebulizador e método de fabricação de um gerador de aerossol - Google Patents

gerador de aerossol, nebulizador e método de fabricação de um gerador de aerossol

Info

Publication number
BR112018016110A2
BR112018016110A2 BR112018016110A BR112018016110A BR112018016110A2 BR 112018016110 A2 BR112018016110 A2 BR 112018016110A2 BR 112018016110 A BR112018016110 A BR 112018016110A BR 112018016110 A BR112018016110 A BR 112018016110A BR 112018016110 A2 BR112018016110 A2 BR 112018016110A2
Authority
BR
Brazil
Prior art keywords
nebulizer
aerosol generator
air stream
water
encapsulation
Prior art date
Application number
BR112018016110A
Other languages
English (en)
Other versions
BR112018016110B1 (pt
Inventor
Hijlkema Markus
Original Assignee
Koninklijke Philips Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of BR112018016110A2 publication Critical patent/BR112018016110A2/pt
Publication of BR112018016110B1 publication Critical patent/BR112018016110B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0653—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
    • B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
    • B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
    • B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
    • B05B17/0638—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers spray being produced by discharging the liquid or other fluent material through a plate comprising a plurality of orifices
    • B05B17/0646—Vibrating plates, i.e. plates being directly subjected to the vibrations, e.g. having a piezoelectric transducer attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Special Spraying Apparatus (AREA)
  • Medicinal Preparation (AREA)

Abstract

trata-se de nebulizadores que são usados para fornecer um medicamento aos pulmões de um paciente sob a forma de uma corrente de ar, com fluido compreendendo o medicamento arrastado na corrente de ar. para possibilitar que o fluido seja arrastado na corrente de ar, um nebulizador contém um gerador de aerossol que compreende, tipicamente, um elemento vibratório (28) com um atuador piezoelétrico. existe uma necessidade de esterilizar frequentemente o nebulizador. isso envolve a imersão do nebulizador em água fervente durante um tempo significativo. descobriu-se que ciclos de esterilização repetidos podem forçar a água através de vãos no elemento vibratório, e sua encapsulação (26), e danificar o elemento piezo. a presente invenção propõe vedar mais eficazmente o piezo do elemento vibratório (28) contra os efeitos do ingresso de água. em particular, é proposto criar, em uma interface do elemento vibratório (28) e do elemento de encapsulação (26), uma descontinuidade que fornece uma geometria de barreira. através de forças capilares, o avanço da água em direção ao elemento piezelétrico (12) compreendido no elemento vibratório (28) é detido, e o tempo de vida do gerador de aerossol é aprimorado.
BR112018016110-1A 2016-02-08 2017-01-25 Gerador de aerossol, nebulizador e método de fabricação de um gerador de aerossol BR112018016110B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16154653 2016-02-08
EP16154653.6 2016-02-08
PCT/EP2017/051453 WO2017137252A1 (en) 2016-02-08 2017-01-25 An aerosol generator

Publications (2)

Publication Number Publication Date
BR112018016110A2 true BR112018016110A2 (pt) 2019-01-02
BR112018016110B1 BR112018016110B1 (pt) 2023-01-24

Family

ID=55345711

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018016110-1A BR112018016110B1 (pt) 2016-02-08 2017-01-25 Gerador de aerossol, nebulizador e método de fabricação de um gerador de aerossol

Country Status (6)

Country Link
US (1) US11376375B2 (pt)
EP (1) EP3413959B1 (pt)
JP (1) JP7084309B2 (pt)
CN (1) CN108601915B (pt)
BR (1) BR112018016110B1 (pt)
WO (1) WO2017137252A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3127616B1 (en) * 2015-08-03 2017-10-18 PARI Pharma GmbH Method of manufacturing a vibratable head for an aerosol generator and vibratable head for an aerosol generator
EP3950141A1 (en) * 2017-12-14 2022-02-09 Stamford Devices Limited Mounting of an aerosol generator aperture plate to a support
MX2020012960A (es) * 2018-05-31 2021-04-28 Vapotherm Inc Nebulizador de malla vibratoria basado en canula.
GB2579569B (en) * 2018-12-03 2023-08-02 Ttp Plc Liquid droplet production apparatus
US11992851B2 (en) * 2018-12-12 2024-05-28 Shl Medical Ag Aerosol unit
CN114728147A (zh) 2019-09-26 2022-07-08 蒸汽热能公司 插管内部安装的雾化器

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US709848A (en) 1901-11-18 1902-09-23 John L Creveling Combined dynamo and driving-gear.
JPS5913264B2 (ja) * 1978-05-04 1984-03-28 松下電器産業株式会社 超音波液体霧化装置
US4850534A (en) 1987-05-30 1989-07-25 Tdk Corporation Ultrasonic wave nebulizer
JP2772319B2 (ja) * 1992-07-13 1998-07-02 矢崎総業株式会社 コネクタのシール構造
US6014970A (en) * 1998-06-11 2000-01-18 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
US6205999B1 (en) 1995-04-05 2001-03-27 Aerogen, Inc. Methods and apparatus for storing chemical compounds in a portable inhaler
DE19847923C1 (de) * 1998-10-19 2000-03-02 Smr Stiegler Maschinenfabrik G Ablegeeinrichtung für Bahnabschnitte aus Folienmaterial
US20070044792A1 (en) 2005-08-30 2007-03-01 Aerogen, Inc. Aerosol generators with enhanced corrosion resistance
EP1509259B1 (en) * 2002-05-20 2016-04-20 Novartis AG Apparatus for providing aerosol for medical treatment and methods
JP3885744B2 (ja) 2003-02-25 2007-02-28 株式会社デンソー ノックセンサ
JP4661142B2 (ja) 2004-09-14 2011-03-30 富士ゼロックス株式会社 カラー画像形成装置
TWI268179B (en) 2005-04-12 2006-12-11 Ind Tech Res Inst Improved structure of atomizing nozzle the plate can be vibrated by the vibrator element to compress the fluid, so that the fluid is jet from the perforations in form of tiny particle
US9108211B2 (en) 2005-05-25 2015-08-18 Nektar Therapeutics Vibration systems and methods
ES2360634T3 (es) * 2006-04-05 2011-06-07 Microdose Therapeutx, Inc. Dispositivo de inhalación de dosis variables.
EP1952896B1 (en) 2007-02-01 2012-11-07 EP Systems SA Droplet dispenser
EP1977778A1 (en) 2007-04-06 2008-10-08 Markos Mefar S.P.A. Electronic nebulizer for washing the nasal cavities of a user
US20090242660A1 (en) * 2008-03-25 2009-10-01 Quatek Co., Ltd. Medical liquid droplet apparatus
CN201200951Y (zh) * 2008-06-05 2009-03-04 刘淑芹 一种压电桥式梁驱动的液体喷射结构
JP5154658B2 (ja) 2008-10-24 2013-02-27 パナソニック株式会社 弾性表面波霧化装置
WO2010089822A1 (ja) 2009-02-09 2010-08-12 株式会社村田製作所 霧化部材及びそれを備える霧化器
EP2982445B1 (en) * 2010-10-04 2019-03-13 Stamford Devices Limited An aerosol generator
MX348852B (es) 2011-09-19 2017-07-03 Koninklijke Philips Nv Nebulizador, unidad de control que controla el mismo, elemento de nebulizacion y metodo de operación del nebulizador.
JP5652790B2 (ja) * 2011-09-22 2015-01-14 オムロンヘルスケア株式会社 液体噴霧装置
DE102012204302A1 (de) * 2012-03-19 2013-09-19 Robert Bosch Gmbh Umspritztes Bauelement mit einem Dichtlabyrinth
JP2013230109A (ja) * 2012-04-27 2013-11-14 Sumitomo Chemical Co Ltd 超音波霧化装置
TWM450428U (zh) * 2012-10-19 2013-04-11 Microbase Technology Corp 噴孔片改良之霧化裝置
JP5913264B2 (ja) * 2013-11-19 2016-04-27 リンナイ株式会社 暖房機
RU2676981C1 (ru) 2013-12-19 2019-01-14 Конинклейке Филипс Н.В. Устройство для образования капель жидкости
EP2886185A1 (en) 2013-12-20 2015-06-24 Activaero GmbH Perforated membrane and process for its preparation
CN204709559U (zh) * 2015-05-04 2015-10-21 德技股份有限公司 雾化器
DE202015102538U1 (de) 2015-05-19 2015-07-30 Quatek Holding Inc. Atomizer

Also Published As

Publication number Publication date
EP3413959B1 (en) 2020-06-17
CN108601915B (zh) 2021-09-21
US11376375B2 (en) 2022-07-05
WO2017137252A1 (en) 2017-08-17
CN108601915A (zh) 2018-09-28
BR112018016110B1 (pt) 2023-01-24
US20190038851A1 (en) 2019-02-07
EP3413959A1 (en) 2018-12-19
JP7084309B2 (ja) 2022-06-14
JP2019503816A (ja) 2019-02-14

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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