BR112018014842A2 - biomarcadores de doenças hepática gordurosa não alcoólica (nafld) e esteato-hepatite não alcoólica (nash) e utilização dos mesmos - Google Patents

biomarcadores de doenças hepática gordurosa não alcoólica (nafld) e esteato-hepatite não alcoólica (nash) e utilização dos mesmos

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Publication number
BR112018014842A2
BR112018014842A2 BR112018014842A BR112018014842A BR112018014842A2 BR 112018014842 A2 BR112018014842 A2 BR 112018014842A2 BR 112018014842 A BR112018014842 A BR 112018014842A BR 112018014842 A BR112018014842 A BR 112018014842A BR 112018014842 A2 BR112018014842 A2 BR 112018014842A2
Authority
BR
Brazil
Prior art keywords
nonalcoholic
nash
liver disease
fatty liver
nafld
Prior art date
Application number
BR112018014842A
Other languages
English (en)
Other versions
BR112018014842A8 (pt
Inventor
Field Stuart
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somalogic Inc filed Critical Somalogic Inc
Publication of BR112018014842A2 publication Critical patent/BR112018014842A2/pt
Publication of BR112018014842A8 publication Critical patent/BR112018014842A8/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente invenção refere-se a métodos, composições e kits para determinar se um indivíduo tem doença hepática gordurosa não alcoólica (nafld) e, mais especificamente, uma ou mais das seguintes condições associadas de esteatose, inflamação lobular, emborcamento de hepatócitos e fibrose, são fornecidas. métodos, composições e kits para determinar se um sujeito tem esteatose não alcoólica (nash) também são fornecidos. métodos, composições e kits para determinar se um sujeito tem esteato-hepatite não alcoólica (nash) também são fornecidos.
BR112018014842A 2016-02-08 2017-02-07 Métodos para determinar se um indivíduo tem doença hepática gordurosa não alcoólica (nafld) inflamação lobular, fibrose e hepatócitos balonizados referência cruzada aos pedidos relacionados BR112018014842A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662292582P 2016-02-08 2016-02-08
US201662362019P 2016-07-13 2016-07-13
PCT/US2017/016798 WO2017139254A1 (en) 2016-02-08 2017-02-07 Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof

Publications (2)

Publication Number Publication Date
BR112018014842A2 true BR112018014842A2 (pt) 2018-12-18
BR112018014842A8 BR112018014842A8 (pt) 2022-10-18

Family

ID=58044222

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018014842A BR112018014842A8 (pt) 2016-02-08 2017-02-07 Métodos para determinar se um indivíduo tem doença hepática gordurosa não alcoólica (nafld) inflamação lobular, fibrose e hepatócitos balonizados referência cruzada aos pedidos relacionados

Country Status (7)

Country Link
US (2) US20210215711A1 (pt)
EP (1) EP3414575A1 (pt)
KR (1) KR20180105156A (pt)
CN (2) CN116008563A (pt)
BR (1) BR112018014842A8 (pt)
MX (1) MX2018009170A (pt)
WO (1) WO2017139254A1 (pt)

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WO2019094777A1 (en) * 2017-11-13 2019-05-16 Gilead Sciences, Inc. Compositions and methods for identifying and treating liver diseases and monitoring treatment outcomes
CA3082591A1 (en) * 2017-11-15 2019-05-23 Beth Israel Deaconess Medical Center, Inc. Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (nash) and advanced liver fibrosis
KR102341336B1 (ko) * 2019-11-20 2021-12-21 숙명여자대학교산학협력단 만성간질환의 예후 예측용 바이오마커 조성물
WO2021101146A1 (ko) * 2019-11-20 2021-05-27 숙명여자대학교산학협력단 만성간질환의 예후 예측 또는 진행 단계 판별용 바이오마커 조성물
WO2022014580A1 (ja) * 2020-07-13 2022-01-20 国立大学法人信州大学 非アルコール性脂肪性肝疾患マーカー、非アルコール性脂肪性肝疾患を検出するための方法、それに用いる試薬及び分析用キット
CN116438456A (zh) * 2020-09-11 2023-07-14 格里姆普斯生物股份有限公司 用于疾病检测/诊断、分期、监测和治疗的离体蛋白酶活性检测
US20220130544A1 (en) * 2020-10-23 2022-04-28 Remmie, Inc Machine learning techniques to assist diagnosis of ear diseases
CN112626198A (zh) * 2020-12-25 2021-04-09 杭州师范大学附属医院 一种肝病重症化的分子标志物及其应用
CN114525330B (zh) * 2021-04-08 2023-11-03 四川大学华西第二医院 一种用于评估非酒精性脂肪性肝炎的标记物组
WO2023008673A1 (ko) * 2021-07-30 2023-02-02 숙명여자대학교산학협력단 머신러닝 기반 비알코올성 지방간염 판별용 복합 마커 및 이의 용도
KR20230130433A (ko) 2022-03-03 2023-09-12 충남대학교산학협력단 miRNA204를 포함하는 비알코올성 지방간 질환 진단용 바이오마커 조성물
US20240071625A1 (en) * 2022-08-29 2024-02-29 Cedars-Sinai Medical Center Nafld identification and prediction systems and methods

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DK0786469T3 (da) 1990-06-11 2006-07-10 Gilead Sciences Inc Nukleinsyreligander
US5580737A (en) 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US6001577A (en) 1998-06-08 1999-12-14 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
US5763177A (en) 1990-06-11 1998-06-09 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex
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US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US6458539B1 (en) 1993-09-17 2002-10-01 Somalogic, Inc. Photoselection of nucleic acid ligands
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CN101218341A (zh) * 2005-05-05 2008-07-09 明尼苏达大学董事会 Nk细胞抑制作用用于促进定植的mhc-i阴性细胞持续存在的用途
US7947447B2 (en) 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7855054B2 (en) 2007-01-16 2010-12-21 Somalogic, Inc. Multiplexed analyses of test samples
CN103627792A (zh) 2007-07-17 2014-03-12 私募蛋白质体公司 检测样品的多元分析
SG10201508656VA (en) 2010-07-09 2015-11-27 Somalogic Inc Lung cancer biomarkers and uses thereof
MX341517B (es) * 2010-08-13 2016-08-24 Somalogic Inc Biomarcadores de cancer pancreatico y usos de los mismos.
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MX2014003153A (es) * 2011-09-30 2014-04-30 Somalogic Inc Prediccion de riesgo de evento cardiovascular y usos del mismo.
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US20170335395A1 (en) * 2014-10-27 2017-11-23 The Trustees Of The University Of Pennsylvania A parkinson's disease diagnostic biomarker panel

Also Published As

Publication number Publication date
CN108603887A (zh) 2018-09-28
MX2018009170A (es) 2018-11-19
BR112018014842A8 (pt) 2022-10-18
US20240094222A1 (en) 2024-03-21
KR20180105156A (ko) 2018-09-27
WO2017139254A1 (en) 2017-08-17
EP3414575A1 (en) 2018-12-19
CN116008563A (zh) 2023-04-25
CN108603887B (zh) 2023-01-13
US20210215711A1 (en) 2021-07-15

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Legal Events

Date Code Title Description
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B25D Requested change of name of applicant approved

Owner name: SOMALOGIC OPERATING CO., INC. (US)