SG10201508656VA - Lung cancer biomarkers and uses thereof - Google Patents

Lung cancer biomarkers and uses thereof

Info

Publication number
SG10201508656VA
SG10201508656VA SG10201508656VA SG10201508656VA SG10201508656VA SG 10201508656V A SG10201508656V A SG 10201508656VA SG 10201508656V A SG10201508656V A SG 10201508656VA SG 10201508656V A SG10201508656V A SG 10201508656VA SG 10201508656V A SG10201508656V A SG 10201508656VA
Authority
SG
Singapore
Prior art keywords
lung cancer
cancer biomarkers
biomarkers
lung
cancer
Prior art date
Application number
SG10201508656VA
Inventor
Sheri Wilcox
Deborah Ayers
Nebojsa Janjic
Larry Gold
Michael Riel-Mehan
Thale Jarvis
Original Assignee
Somalogic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somalogic Inc filed Critical Somalogic Inc
Publication of SG10201508656VA publication Critical patent/SG10201508656VA/en

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57423Specifically defined cancers of lung
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/30Unsupervised data analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00Subject matter not provided for in other groups of this subclass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/16Primer sets for multiplex assays
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
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  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Data Mining & Analysis (AREA)
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SG10201508656VA 2010-07-09 2011-07-11 Lung cancer biomarkers and uses thereof SG10201508656VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36312210P 2010-07-09 2010-07-09
US201161444947P 2011-02-21 2011-02-21

Publications (1)

Publication Number Publication Date
SG10201508656VA true SG10201508656VA (en) 2015-11-27

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SG10201508656VA SG10201508656VA (en) 2010-07-09 2011-07-11 Lung cancer biomarkers and uses thereof
SG2013001003A SG186953A1 (en) 2010-07-09 2011-07-11 Lung cancer biomarkers and uses thereof

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Country Status (12)

Country Link
US (3) US20130116150A1 (en)
EP (1) EP2591357A4 (en)
JP (1) JP5905003B2 (en)
KR (1) KR101870123B1 (en)
CN (2) CN102985819B (en)
AU (1) AU2011274422B2 (en)
BR (1) BR112012032537B8 (en)
CA (1) CA2801110C (en)
IL (1) IL223295A (en)
MX (2) MX2012014268A (en)
SG (2) SG10201508656VA (en)
WO (1) WO2012006632A2 (en)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4991847B2 (en) * 2006-05-09 2012-08-01 ザ ユニバーシティ オブ ブリティッシュ コロンビア Dissolved protein arthritis marker
CN101952313B (en) 2007-11-27 2017-12-15 不列颠哥伦比亚大学 14 33 η antibody and its for diagnose and treatment of arthritis purposes
US8285719B1 (en) 2008-08-08 2012-10-09 The Research Foundation Of State University Of New York System and method for probabilistic relational clustering
US10359425B2 (en) * 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
US20100221752A2 (en) * 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
KR101894597B1 (en) 2009-03-11 2018-10-04 오거렉스 라이프 사이언시스 코포레이션 Compositions and methods for characterizing arthritic conditions
CA2801110C (en) 2010-07-09 2021-10-05 Somalogic, Inc. Lung cancer biomarkers and uses thereof
CA2804857C (en) 2010-08-13 2021-07-06 Somalogic, Inc. Pancreatic cancer biomarkers and uses thereof
US20140235487A1 (en) * 2010-11-12 2014-08-21 William Marsh Rice University Oral cancer risk scoring
US10132806B2 (en) 2011-10-21 2018-11-20 Augurex Life Sciences Corp. Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis
US20130282390A1 (en) * 2012-04-20 2013-10-24 International Business Machines Corporation Combining knowledge and data driven insights for identifying risk factors in healthcare
US20150088430A1 (en) * 2012-04-26 2015-03-26 Allegro Diagnostics Corp Methods for evaluating lung cancer status
JP6022285B2 (en) * 2012-09-28 2016-11-09 シスメックス株式会社 Specimen storage device, specimen storage method, and specimen inspection system
EP2912182B1 (en) 2012-10-23 2021-12-08 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
CN104812913B (en) 2012-11-07 2019-03-15 私募蛋白质体公司 Chronic Obstructive Pulmonary Disease (COPD) biomarker and application thereof
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
EP3626308A1 (en) 2013-03-14 2020-03-25 Veracyte, Inc. Methods for evaluating copd status
EP3296747B1 (en) 2013-03-15 2020-01-08 Somalogic, Inc. Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof
WO2014153327A1 (en) 2013-03-18 2014-09-25 Barbeau James M Methods to determine carcinogenesis, identify markers for early cancer diagnosis and identify targets of therapy
US10501803B2 (en) * 2013-05-21 2019-12-10 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Isoforms of GATA6 and NKX2-1 as markers for diagnosis and therapy of cancer and as targets for anti-cancer therapy
KR101552014B1 (en) 2013-10-11 2015-09-09 인제대학교 산학협력단 Novel use of NIR for diagnosing lung cancer
WO2015066564A1 (en) * 2013-10-31 2015-05-07 Cancer Prevention And Cure, Ltd. Methods of identification and diagnosis of lung diseases using classification systems and kits thereof
KR102310799B1 (en) * 2013-11-07 2021-10-12 미디얼 리서치 리미티드 Methods and systems of evaluating a risk of lung cancer
JP6703479B2 (en) * 2013-12-16 2020-06-03 フィリップ モリス プロダクツ エス アー System and method for predicting individual smoking status
RU2538625C1 (en) * 2014-01-20 2015-01-10 Денис Николаевич Бахмутов Diagnostic technique for cancer
WO2015164617A1 (en) 2014-04-24 2015-10-29 Somalogic, Inc. Tuberculosis biomarkers in urine and uses thereof
WO2015164616A1 (en) 2014-04-24 2015-10-29 Somalogic, Inc. Biomarkers for detection of tuberculosis
WO2015164772A1 (en) * 2014-04-25 2015-10-29 Rush University Medical Center Circulating insulin-like growth factor (igf)-associated proteins for the detection of lung cancer
CN114807368A (en) * 2014-07-14 2022-07-29 威拉赛特公司 Methods for assessing lung cancer status
AU2014407088B2 (en) 2014-09-26 2021-09-23 Somalogic Operating Co., Inc. Cardiovascular risk event prediction and uses thereof
CN107206043A (en) 2014-11-05 2017-09-26 维拉赛特股份有限公司 The system and method for diagnosing idiopathic pulmonary fibrosis on transbronchial biopsy using machine learning and higher-dimension transcript data
WO2016123058A1 (en) 2015-01-27 2016-08-04 Somalogic, Inc. Biomarkers for detection of tuberculosis risk
US20180356419A1 (en) 2015-05-08 2018-12-13 Somalogic, Inc. Biomarkers for detection of tuberculosis risk
EP3347720A1 (en) * 2015-09-09 2018-07-18 Somalogic, Inc. Methods for developing personalized drug treatment plans and targeted drug development based on proteomic profiles
CN108026584B (en) * 2015-09-11 2021-12-10 适体科学株式会社 Protein biomarker panel for diagnosing non-small cell lung cancer and non-small cell lung cancer diagnosis method using same
US10546650B2 (en) 2015-10-23 2020-01-28 Google Llc Neural network for processing aptamer data
MX2018009170A (en) 2016-02-08 2018-11-19 Somalogic Inc Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof.
JP6041331B1 (en) * 2016-02-26 2016-12-07 国立大学法人山口大学 Information processing apparatus, information processing program, and information processing method
JP6889428B2 (en) * 2016-02-26 2021-06-18 国立大学法人山口大学 Information processing equipment, information processing programs, and information processing methods
CN107435062B (en) * 2016-05-25 2020-10-20 上海伯豪医学检验所有限公司 Peripheral blood gene marker for discriminating benign and malignant pulmonary nodules and application thereof
JP7058264B2 (en) * 2016-06-08 2022-04-21 リサーチ ディヴェロプメント ファウンデーション Systems and methods for automatic feature analysis and risk assessment of coronary plaques using intravascular optical coherence tomography
BR112018076528A2 (en) * 2016-06-21 2019-04-02 The Wistar Institute Of Anatomy And Biology compositions and methods for diagnosing lung cancers using gene expression profiles
EP3629904A4 (en) * 2017-06-02 2021-03-31 Veracyte, Inc. Methods and systems for identifying or monitoring lung disease
CN109470855B (en) * 2017-09-08 2022-02-11 广州市丹蓝生物科技有限公司 Protein chip and kit for early diagnosis of lung cancer
KR102028967B1 (en) 2017-12-28 2019-10-07 한국원자력의학원 Biomarker for lung cancer metastasis diagnosis comprising rip1 and use thereof
US20210140977A1 (en) 2018-04-16 2021-05-13 University Of Cape Town A three-protein proteomic biomarker for prospective determination of risk for development of active tuberculosis
CA3104041A1 (en) * 2018-06-22 2019-12-26 Somalogic, Inc. Improved proteomic multiplex assays
WO2020018005A1 (en) * 2018-07-17 2020-01-23 Limited Liability Company "Gero" Devices, methods, compositions and systems for the treatment of aging and age- related disorders
KR102216645B1 (en) * 2018-10-29 2021-02-17 사회복지법인 삼성생명공익재단 Biomarker panel for determination of molecular subtype of lung cancer and uses thereof
KR20210089178A (en) * 2018-10-30 2021-07-15 소마로직, 인크. How to evaluate sample quality
CN109470859A (en) * 2018-11-04 2019-03-15 华东医院 A kind of excretion body protein is as identifying the good pernicious marker of Lung neoplasm and its application
EP3671210A1 (en) * 2018-12-21 2020-06-24 Biosystems International KFT Lung cancer protein epitomic biomarkers
WO2020243574A1 (en) * 2019-05-31 2020-12-03 Delphinus Medical Technologies, Inc. Systems and methods for interactive lesion characterization
US20210027890A1 (en) * 2019-07-24 2021-01-28 ConnSante BioTech, Inc. Detecting, evaluating and predicting system for cancer risk
CA3151482A1 (en) 2019-09-03 2021-03-11 Somalogic Operating Co., Inc. Cardiovascular risk event prediction and uses thereof
JP2023509677A (en) 2020-01-10 2023-03-09 ソマロジック オペレーティング カンパニー インコーポレイテッド Methods for determining impaired glucose tolerance
GB2603051B (en) 2020-01-30 2023-04-26 Prognomiq Inc Lung biomarkers and methods of use thereof
CN115066616A (en) 2020-02-10 2022-09-16 私募蛋白质体操作有限公司 Non-alcoholic steatohepatitis (NASH) biomarker and application thereof
KR102260915B1 (en) 2020-02-19 2021-06-04 한국원자력의학원 Biomaker for predictiong prognosis of lung cancer after radiotherapy
CN111876478A (en) * 2020-04-28 2020-11-03 中国科学院微生物研究所 Pulmonary nodule diagnostic marker and application
US20230304099A1 (en) * 2020-08-14 2023-09-28 The Medical College Of Wisconsin, Inc. Gene Expression Signature for Predicting Immunotherapy Response and Methods of Use
KR20230080442A (en) * 2020-10-02 2023-06-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Methods for Detection and Treatment of Lung Cancer
WO2022073502A1 (en) * 2020-10-10 2022-04-14 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) Use of biomarker in preparation of lung cancer detection reagent and related method
AU2021364805A1 (en) 2020-10-20 2023-05-18 Somalogic Operating Co., Inc. Cardiovascular event risk prediction
GB2607436A (en) * 2021-03-31 2022-12-07 Prognomiq Inc Multi-omic assessment
WO2023141248A1 (en) 2022-01-21 2023-07-27 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211769A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211771A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211770A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023211773A1 (en) 2022-04-24 2023-11-02 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2023244582A1 (en) * 2022-06-13 2023-12-21 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Lung cancer-related biomarkers and methods of using the same
WO2024010854A1 (en) * 2022-07-07 2024-01-11 Diagnose Early, Inc. Rapid generation of breath-based health reports and systems for use in the same
WO2024015485A1 (en) 2022-07-14 2024-01-18 Somalogic Operating Co., Inc. Methods of assessing dementia risk
WO2024015486A1 (en) 2022-07-14 2024-01-18 Somalogic Operating Co., Inc. Methods for sample quality assessment
WO2024064322A2 (en) 2022-09-23 2024-03-28 Somalogic Operating Co., Inc. Methods of assessing tobacco use status

Family Cites Families (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US20040254101A1 (en) 1995-06-06 2004-12-16 Human Genome Sciences, Inc. Colon specific gene and protein and cancer
US6004267A (en) 1997-03-07 1999-12-21 University Of Florida Method for diagnosing and staging prostate cancer
WO2000052204A2 (en) 1999-02-22 2000-09-08 Orntoft Torben F Gene expression in bladder tumors
KR100768985B1 (en) 1999-09-10 2007-10-22 무라마쯔 다카시 Early cancer tumor marker
EP1472352A4 (en) 2000-03-06 2005-10-12 Smithkline Beecham Corp Novel compounds
US20030224501A1 (en) 2000-03-17 2003-12-04 Young Paul E. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
US6596503B1 (en) 2000-08-18 2003-07-22 East Carolina University Monoclonal antibody DS6, tumor-associated antigen CA6, and methods of use thereof
US6631330B1 (en) 2000-08-21 2003-10-07 Assistance Publique-Hopitaux De Paris (Ap-Hp) Diagnosis method of inflammatory, fibrotic or cancerous disease using biochemical markers
US6576423B2 (en) 2000-12-08 2003-06-10 The Board Of Regents Of The University Of Nebraska Specific mucin expression as a marker for pancreatic cancer
AU2002309583A1 (en) * 2001-04-18 2002-11-05 Protein Desing Labs, Inc. Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
US7189507B2 (en) 2001-06-18 2007-03-13 Pdl Biopharma, Inc. Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer
US7622260B2 (en) 2001-09-05 2009-11-24 The Brigham And Women's Hospital, Inc. Diagnostic and prognostic tests
US20040009489A1 (en) 2001-09-28 2004-01-15 Golub Todd R. Classification of lung carcinomas using gene expression analysis
US20040241653A1 (en) * 2001-12-31 2004-12-02 Elena Feinstein Methods for identifying marker genes for cancer
EP2241636A1 (en) 2002-03-13 2010-10-20 Genomic Health, Inc. Gene expression profiling in biopsied tumor tissues
US20050260639A1 (en) 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Method for diagnosing pancreatic cancer
CA2500472A1 (en) 2002-09-30 2004-04-15 Oncotherapy Science, Inc. Genes and polypeptides relating to human pancreatic cancers
US8008003B2 (en) 2002-11-15 2011-08-30 Genomic Health, Inc. Gene expression profiling of EGFR positive cancer
US20040219572A1 (en) 2002-12-17 2004-11-04 Jie Chen Specific markers for pancreatic cancer
WO2004061410A2 (en) 2002-12-18 2004-07-22 Ciphergen Biosystems, Inc. Serum biomarkers in lung cancer
US20050181375A1 (en) 2003-01-10 2005-08-18 Natasha Aziz Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
AU2003900747A0 (en) 2003-02-18 2003-03-06 Garvan Institute Of Medical Research Diagnosis and treatment of pancreatic cancer
DE602004017426D1 (en) 2003-02-20 2008-12-11 Genomic Health Inc USE OF INTRONIC RNA SEQUENCES FOR THE QUANTIFICATION OF GENE EXPRESSION
CA2516591A1 (en) 2003-02-26 2004-09-10 Mount Sinai Hospital Multiple marker assay for detection of ovarian cancer
US20050095611A1 (en) 2003-05-02 2005-05-05 Chan Daniel W. Identification of biomarkers for detecting pancreatic cancer
CN1455257A (en) * 2003-05-23 2003-11-12 北京师范大学 Method of diagnosing lung cancer using surface modified protein chip
US20060019256A1 (en) 2003-06-09 2006-01-26 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
ES2609234T3 (en) 2003-06-24 2017-04-19 Genomic Health, Inc. Prediction of the probability of cancer recurrence
EP1644858B1 (en) 2003-07-10 2017-12-06 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
US20050069963A1 (en) 2003-08-15 2005-03-31 Lokshin Anna E. Multifactorial assay for cancer detection
US7807392B1 (en) 2003-09-15 2010-10-05 Celera Corporation Lung disease targets and uses thereof
US20070148648A1 (en) 2003-11-04 2007-06-28 Martin Dugas Method for distinguishing who classified aml subtypes
EP2026071B1 (en) 2004-02-19 2013-07-31 Yale University Identification of cancer protein biomarkers using proteomic techniques
JP2007527247A (en) 2004-03-05 2007-09-27 ロゼッタ インファーマティクス エルエルシー Classification of breast cancer patients using a combination of clinical criteria and informative gene sets
EP2163650B1 (en) 2004-04-09 2015-08-05 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
ES2367311T3 (en) 2004-04-15 2011-11-02 University Of Florida Research Foundation, Inc. MAP-2 PROTEOLYTIC DEGRADATION PRODUCTS AS DIAGNOSTIC BIOMARCATORS FOR NEURAL INJURIES.
EP1743031A4 (en) 2004-04-26 2008-05-28 Childrens Medical Center Platelet biomarkers for the detection of disease
US20070275422A1 (en) 2004-07-26 2007-11-29 The Board Of Trustees Of The Leland Stanford Jr. U Methods and Compositions for Detecting Pancreatic Disease
WO2006022895A2 (en) 2004-08-02 2006-03-02 Children's Medical Center Corporation Platelet biomarkers for cancer
EP1787122B1 (en) 2004-08-10 2010-10-06 Oncotherapy Science, Inc. NON-SMALL CELL LUNG CANCER-RELATED GENE, ANLN, AND ITS INTERACTIONS WITH RhoA
JP2006053113A (en) * 2004-08-16 2006-02-23 Medical Proteoscope Co Ltd Method and kit for diagnosing pulmonary adenocarcinoma lymph node metastasis
DK1836629T3 (en) 2004-11-05 2020-05-18 Genomic Health Inc PREDICTION OF RESPONSE TO CHEMOTHERAPY USING MARKERS FOR GENEPRESSION
AU2005304878B2 (en) 2004-11-05 2010-07-08 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and prediction of treatment response
US7862995B2 (en) 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
US8632983B2 (en) 2005-04-15 2014-01-21 Van Andel Research Institute Biomarkers for pancreatic cancer and diagnostic methods
WO2006135886A2 (en) 2005-06-13 2006-12-21 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20090005268A1 (en) 2005-07-18 2009-01-01 Epigenomics Ag Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers
US7521195B1 (en) 2005-07-21 2009-04-21 Celera Corporation Lung disease targets and uses thereof
EP2295571A1 (en) 2005-07-27 2011-03-16 Oncotherapy Science, Inc. Method of diagnosing small cell lung cancer
EP1937837A2 (en) 2005-07-29 2008-07-02 Siemens Healthcare Diagnostics Inc. Methods and kits for the prediction of therapeutic success, recurrence free and overall survival in cancer therapies
US7582441B1 (en) 2005-10-17 2009-09-01 Celera Corporation Methods and compositions for treating and diagnosing disease
EP1777523A1 (en) 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
US8329408B2 (en) 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
CA2632190A1 (en) * 2005-11-10 2007-07-12 University Of Kentucky Lung cancer diagnostic assay
US8445198B2 (en) 2005-12-01 2013-05-21 Medical Prognosis Institute Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
US8014957B2 (en) 2005-12-15 2011-09-06 Fred Hutchinson Cancer Research Center Genes associated with progression and response in chronic myeloid leukemia and uses thereof
WO2007076439A2 (en) 2005-12-22 2007-07-05 Abbott Laboratories Methods and marker combinations for screening for predisposition to lung cancer
NZ593228A (en) 2006-01-11 2012-10-26 Genomic Health Inc Gene expression markers (inhba) for colorectal cancer prognosis
MX2008009592A (en) 2006-01-27 2008-09-08 Tripath Imaging Inc Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor.
WO2007092433A2 (en) 2006-02-06 2007-08-16 Tethys Bioscience, Inc. Osteoporosis associated markers and methods of use thereof
WO2007109571A2 (en) 2006-03-17 2007-09-27 Prometheus Laboratories, Inc. Methods of predicting and monitoring tyrosine kinase inhibitor therapy
US7888019B2 (en) 2006-03-31 2011-02-15 Genomic Health, Inc. Genes involved estrogen metabolism
ES2550004T3 (en) 2006-04-04 2015-11-03 Singulex, Inc. High sensitivity system and troponin analysis methods
WO2007146229A2 (en) 2006-06-07 2007-12-21 Tethys Bioscience, Inc. Markers associated with arteriovascular events and methods of use thereof
WO2008003024A2 (en) 2006-06-28 2008-01-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Method and composition for diagnosing endometrial cancer
EP2090665A2 (en) 2006-10-20 2009-08-19 Exiqon A/S Novel human microRNAs associated with cancer
WO2008063413A2 (en) * 2006-11-13 2008-05-29 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of lung cancer
US7964356B2 (en) 2007-01-16 2011-06-21 Somalogic, Inc. Method for generating aptamers with improved off-rates
US7947447B2 (en) * 2007-01-16 2011-05-24 Somalogic, Inc. Method for generating aptamers with improved off-rates
KR100846354B1 (en) * 2007-03-21 2008-07-15 (주) 프로탄바이오 Diagnostic biomarker for lung adenocarcinoma isolated from serum glycoproteins
JP6115801B2 (en) 2007-03-27 2017-04-19 イミュノヴィア・アーベー Protein signature / marker for adenocarcinoma detection
RU2376372C2 (en) 2007-04-03 2009-12-20 Государственное учреждение Научно-исследовательский институт медицинской генетики Томского научного центра Сибирского отделения Российской академии медицинских наук Method for genetic diagnostics of susceptibility to cardiovascular diseases
CA2681667A1 (en) 2007-05-18 2008-11-27 Duke University Serum biomarkers for the early detection of lung cancer
CA2688299A1 (en) 2007-05-29 2008-12-18 President And Fellows Of Harvard College Molecules involved in regulation of osteoblast activity and osteoclast activity, and methods of use thereof
DK2069529T3 (en) * 2007-07-17 2013-04-15 Somalogic Inc Process for generating aptamers with improved dissociation rates
EP2019318A1 (en) 2007-07-27 2009-01-28 Erasmus University Medical Center Rotterdam Protein markers for cardiovascular events
GB0717637D0 (en) 2007-09-10 2007-10-17 Univ Leiden Future cardiac event biomarkers
WO2009036123A1 (en) * 2007-09-11 2009-03-19 Cancer Prevention And Cure, Ltd. Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues
US8541183B2 (en) * 2007-09-11 2013-09-24 Cancer Prevention And Cure, Ltd. Methods of identification, assessment, prevention and therapy of lung diseases and kits thereof
US20100267041A1 (en) 2007-09-14 2010-10-21 Predictive Biosciences, Inc. Serial analysis of biomarkers for disease diagnosis
AU2008302526A1 (en) * 2007-09-18 2009-03-26 Board Of Regents Of The University Of Texas System Detection of saliva proteins modulated secondary to ductal carcinoma in situ of the breast
US7892760B2 (en) 2007-11-19 2011-02-22 Celera Corporation Lung cancer markers, and uses thereof
WO2009091581A2 (en) 2008-01-18 2009-07-23 Vatrix Medical, Inc. Diagnostic biomarkers for vascular aneurysm
GB0803192D0 (en) 2008-02-22 2008-04-02 Mubio Products Bv SCLC biomarker panel
WO2009114836A1 (en) 2008-03-14 2009-09-17 Genomic Health, Inc. Gene expression markers for prediction of patient response to chemotherapy
WO2010030697A1 (en) 2008-09-09 2010-03-18 Somalogic, Inc. Lung cancer biomarkers and uses thereof
US10359425B2 (en) * 2008-09-09 2019-07-23 Somalogic, Inc. Lung cancer biomarkers and uses thereof
US20120143805A1 (en) 2008-09-09 2012-06-07 Somalogic, Inc. Cancer Biomarkers and Uses Thereof
US20100221752A2 (en) 2008-10-06 2010-09-02 Somalogic, Inc. Ovarian Cancer Biomarkers and Uses Thereof
US20120165217A1 (en) 2008-10-06 2012-06-28 Somalogic, Inc. Cancer Biomarkers and Uses Thereof
RU2545757C2 (en) 2008-10-30 2015-04-10 Сантр Де Решерш Пюблик Де Ля Сантэ Biomarkers
GB2477705B (en) 2008-11-17 2014-04-23 Veracyte Inc Methods and compositions of molecular profiling for disease diagnostics
EP2366162A1 (en) 2008-11-18 2011-09-21 Collabrx, Inc. Individualized cancer treatment
CA2745961A1 (en) 2008-12-04 2010-06-10 The Regents Of The University Of California Materials and methods for determining diagnosis and prognosis of prostate cancer
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
ES2623633T3 (en) 2009-06-09 2017-07-11 Gendiag.Exe, S.L. Risk markers for cardiovascular disease
EA201270020A1 (en) 2009-06-15 2012-07-30 Кардиодкс, Инк. DETERMINATION OF THE RISK OF DEVELOPMENT OF ATHEROSCLEROTIC HEART DISEASE
WO2011022552A2 (en) 2009-08-19 2011-02-24 The Cleveland Clinic Foundation Marker Detection for Characterizing the Risk of Cardiovascular Disease or Complications Thereof
WO2011035433A1 (en) * 2009-09-23 2011-03-31 University Health Network Selected strains on serum-free growth media for proteomics analysis of lung cancer biomarkers
WO2011050328A2 (en) 2009-10-22 2011-04-28 The Regents Of The University Of California Assessment of solid tumor burden
EP2494364A1 (en) 2009-10-29 2012-09-05 Tethys Bioscience, Inc. Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
AU2010326066A1 (en) 2009-12-01 2012-06-21 Compendia Bioscience, Inc. Classification of cancers
EP2510116A2 (en) 2009-12-09 2012-10-17 Aviir, Inc. Biomarker assay for diagnosis and classification of cardiovascular disease
WO2011094483A2 (en) 2010-01-29 2011-08-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Immune gene signatures in cancer
US9624547B2 (en) 2010-02-10 2017-04-18 The Regents Of The University Of California Salivary transcriptomic and proteomic biomarkers for breast cancer detection
US9128101B2 (en) 2010-03-01 2015-09-08 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
JP2013526852A (en) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Circulating biomarkers for disease
US20110256545A1 (en) * 2010-04-14 2011-10-20 Nancy Lan Guo mRNA expression-based prognostic gene signature for non-small cell lung cancer
CA2801110C (en) 2010-07-09 2021-10-05 Somalogic, Inc. Lung cancer biomarkers and uses thereof
CA2804857C (en) 2010-08-13 2021-07-06 Somalogic, Inc. Pancreatic cancer biomarkers and uses thereof
EP2622104A4 (en) 2010-09-27 2015-04-15 Somalogic Inc Mesothelioma biomarkers and uses thereof
CN103703371A (en) * 2011-04-29 2014-04-02 癌症预防和治疗有限公司 Methods of identification and diagnosis of lung diseases using classification systems and kits thereof
SG10201607331WA (en) 2011-09-30 2016-11-29 Somalogic Inc Cardiovascular risk event prediction and uses thereof
IN2014CN01787A (en) 2011-10-24 2015-05-29 Somalogic Inc
CN104812913B (en) 2012-11-07 2019-03-15 私募蛋白质体公司 Chronic Obstructive Pulmonary Disease (COPD) biomarker and application thereof
US9938314B2 (en) 2013-11-21 2018-04-10 Somalogic, Inc. Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto

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