BR112018012665A2 - 3-hidroxibutirato desidrogenase mutante de alcaligenes faecalis, ácido nucleico, célula, método para determinar a quantidade ou concentração de 3-hidroxibutirato, uso da 3-hbdh mutante e dispositivo - Google Patents
3-hidroxibutirato desidrogenase mutante de alcaligenes faecalis, ácido nucleico, célula, método para determinar a quantidade ou concentração de 3-hidroxibutirato, uso da 3-hbdh mutante e dispositivoInfo
- Publication number
- BR112018012665A2 BR112018012665A2 BR112018012665A BR112018012665A BR112018012665A2 BR 112018012665 A2 BR112018012665 A2 BR 112018012665A2 BR 112018012665 A BR112018012665 A BR 112018012665A BR 112018012665 A BR112018012665 A BR 112018012665A BR 112018012665 A2 BR112018012665 A2 BR 112018012665A2
- Authority
- BR
- Brazil
- Prior art keywords
- mutant
- hydroxybutyrate
- hbdh
- concentration
- amount
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/0103—3-Hydroxybutyrate dehydrogenase (1.1.1.30)
Abstract
a presente invenção diz respeito a uma 3-hidroxibutirato desidrogenase mutante (3-hbdh) com desempenho melhorado em relação a 3-hbdh tipo selvagem, um ácido nucleico que codifica a 3-hbdh mutante, uma célula compreendendo a 3-hbdh mutante ou o nucleico ácido, um método para determinar a quantidade ou concentração de 3-hidroxibutirato em uma amostra, o uso da 3-hbdh mutante para determinar a quantidade ou concentração de 3-hidroxibutirato em uma amostra e um dispositivo para determinar a quantidade ou concentração de 3-hidroxibutirato em uma amostra.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562270133P | 2015-12-21 | 2015-12-21 | |
EP16165421 | 2016-04-14 | ||
PCT/EP2016/082257 WO2017109003A1 (en) | 2015-12-21 | 2016-12-21 | Mutant 3-hydroxybutyrate dehydrogenase from alcaligenes faecalis as well as methods and uses involving the same |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018012665A2 true BR112018012665A2 (pt) | 2018-12-04 |
Family
ID=55808953
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018012665A BR112018012665A2 (pt) | 2015-12-21 | 2016-12-21 | 3-hidroxibutirato desidrogenase mutante de alcaligenes faecalis, ácido nucleico, célula, método para determinar a quantidade ou concentração de 3-hidroxibutirato, uso da 3-hbdh mutante e dispositivo |
Country Status (6)
Country | Link |
---|---|
US (1) | US10508267B2 (pt) |
EP (1) | EP3394252B1 (pt) |
KR (1) | KR20180087329A (pt) |
CN (1) | CN108350439A (pt) |
BR (1) | BR112018012665A2 (pt) |
WO (1) | WO2017109003A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3414325B1 (en) | 2016-02-09 | 2020-01-29 | Roche Diabetes Care GmbH | Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same |
US20220338768A1 (en) | 2021-04-09 | 2022-10-27 | Medtronic Minimed, Inc. | Hexamethyldisiloxane membranes for analyte sensors |
US20230123613A1 (en) | 2021-10-14 | 2023-04-20 | Medtronic Minimed, Inc. | Sensors for 3-hydroxybutyrate detection |
US20230172497A1 (en) | 2021-12-02 | 2023-06-08 | Medtronic Minimed, Inc. | Ketone limiting membrane and dual layer membrane approach for ketone sensing |
US20230383265A1 (en) * | 2022-05-24 | 2023-11-30 | The University Of North Carolina At Chapel Hill | D-beta-HYDROXYBUTYRATE DEHYDROGENASES (BHBDhs) AND THEIR USE FOR KETONE MONITORING |
Family Cites Families (23)
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US4816224A (en) | 1980-08-05 | 1989-03-28 | Boehringer Mannheim Gmbh | Device for separating plasma or serum from whole blood and analyzing the same |
DE3630999A1 (de) | 1986-09-12 | 1988-03-17 | Boehringer Mannheim Gmbh | Mehrschichtiger testtraeger |
US5413690A (en) | 1993-07-23 | 1995-05-09 | Boehringer Mannheim Corporation | Potentiometric biosensor and the method of its use |
US5762770A (en) | 1994-02-21 | 1998-06-09 | Boehringer Mannheim Corporation | Electrochemical biosensor test strip |
JP3578415B2 (ja) | 1994-09-01 | 2004-10-20 | 旭化成ファーマ株式会社 | 3−ヒドロキシ酪酸脱水素酵素を生産する実質上純粋な微生物 |
US5801006A (en) | 1997-02-04 | 1998-09-01 | Specialty Assays, Inc. | Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites |
US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
DE19815685A1 (de) | 1998-04-08 | 1999-10-14 | Roche Diagnostics Gmbh | Rekombinante mikrobielle 3-Hydroxybuttersäure-Dehydrogenase, Verfahren zu deren Herstellung und Verwendung |
US6541216B1 (en) * | 1999-12-22 | 2003-04-01 | Roche Diagnostics Corporation | Amperometric biosensor test strip |
AU2001262702A1 (en) | 2000-06-07 | 2001-12-17 | Asahi Kasei Kabushiki Kaisha | Coenzyme derivatives and enzymes appropriate therefor |
ES2537106T3 (es) | 2004-10-15 | 2015-06-02 | F. Hoffmann-La Roche Ag | Mutantes termoestables de la glucosa deshidrogenasa dependiente de quinona de pirroloquinolina |
DE102005035461A1 (de) | 2005-07-28 | 2007-02-15 | Roche Diagnostics Gmbh | Stabile NAD/NADH-Derivate |
PT2010649T (pt) | 2006-04-13 | 2017-05-03 | Hoffmann La Roche | Mutantes melhorados da glicose-desidrogenase solúvel dependente de pirroloquinolina quinona |
CN1962876A (zh) * | 2006-11-13 | 2007-05-16 | 于永光 | 酶法测定d-3-羟基丁酸试剂盒 |
DE102007035109A1 (de) * | 2007-07-20 | 2009-01-22 | Universität Leipzig | Neue Enzyme mit Alkoholdehydrogenase-Aktivität |
WO2009060432A1 (en) | 2007-11-07 | 2009-05-14 | Medingo Ltd. | Device and method for preventing diabetic complications |
EP2276574B1 (en) | 2008-04-04 | 2019-06-12 | IT-IS International Ltd | Thermal control system and method for chemical and biochemical reactions |
JP5540096B2 (ja) | 2009-07-27 | 2014-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | カルバ−nadの酵素合成 |
JP2011152094A (ja) | 2010-01-28 | 2011-08-11 | Sony Corp | 耐熱化チロシン依存性酸化還元酵素の設計方法及び耐熱化チロシン依存性酸化還元酵素 |
US8920628B2 (en) | 2012-11-02 | 2014-12-30 | Roche Diagnostics Operations, Inc. | Systems and methods for multiple analyte analysis |
WO2014195363A1 (en) | 2013-06-04 | 2014-12-11 | Roche Diagnostics Gmbh | Novel compounds useful for fret and methods related thereto |
KR101630740B1 (ko) * | 2014-02-07 | 2016-06-15 | 서울대학교산학협력단 | 돌연변이 3-히드록시부티레이트 탈수소효소 |
EP3414325B1 (en) | 2016-02-09 | 2020-01-29 | Roche Diabetes Care GmbH | Mutant 3-hydroxybutyrate dehydrogenase from rhodobacter sphaeroides as well as methods and uses involving the same |
-
2016
- 2016-12-21 EP EP16826037.0A patent/EP3394252B1/en active Active
- 2016-12-21 WO PCT/EP2016/082257 patent/WO2017109003A1/en active Application Filing
- 2016-12-21 KR KR1020187017721A patent/KR20180087329A/ko not_active Application Discontinuation
- 2016-12-21 CN CN201680065136.8A patent/CN108350439A/zh active Pending
- 2016-12-21 BR BR112018012665A patent/BR112018012665A2/pt unknown
-
2018
- 2018-06-21 US US16/014,355 patent/US10508267B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN108350439A (zh) | 2018-07-31 |
US20180291354A1 (en) | 2018-10-11 |
US10508267B2 (en) | 2019-12-17 |
EP3394252B1 (en) | 2020-04-29 |
KR20180087329A (ko) | 2018-08-01 |
EP3394252A1 (en) | 2018-10-31 |
WO2017109003A1 (en) | 2017-06-29 |
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