BR112018009550A2 - derivados de 1,4-benzodiazepinona tricíclica substituída como moduladores alostéricos de receptores de glutamato metabotrópico de grupo ii - Google Patents
derivados de 1,4-benzodiazepinona tricíclica substituída como moduladores alostéricos de receptores de glutamato metabotrópico de grupo iiInfo
- Publication number
- BR112018009550A2 BR112018009550A2 BR112018009550A BR112018009550A BR112018009550A2 BR 112018009550 A2 BR112018009550 A2 BR 112018009550A2 BR 112018009550 A BR112018009550 A BR 112018009550A BR 112018009550 A BR112018009550 A BR 112018009550A BR 112018009550 A2 BR112018009550 A2 BR 112018009550A2
- Authority
- BR
- Brazil
- Prior art keywords
- modulators
- formula
- metabotropic glutamate
- tricyclic
- benzodiazepinone derivatives
- Prior art date
Links
- RGGLEJFUEMKQSH-UHFFFAOYSA-N 1,4-benzodiazepin-2-one Chemical class O=C1C=NC=C2C=CC=CC2=N1 RGGLEJFUEMKQSH-UHFFFAOYSA-N 0.000 title abstract 4
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 title abstract 3
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 title abstract 3
- 230000003281 allosteric effect Effects 0.000 title abstract 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229930195712 glutamate Natural products 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000009206 glutamatergic signaling Effects 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 230000011664 signaling Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15194611 | 2015-11-13 | ||
| PCT/GB2016/053550 WO2017081483A1 (en) | 2015-11-13 | 2016-11-11 | Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group ii metabotropic glutamate receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018009550A2 true BR112018009550A2 (pt) | 2018-11-06 |
Family
ID=54542126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018009550A BR112018009550A2 (pt) | 2015-11-13 | 2016-11-11 | derivados de 1,4-benzodiazepinona tricíclica substituída como moduladores alostéricos de receptores de glutamato metabotrópico de grupo ii |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11008323B2 (enExample) |
| EP (1) | EP3374360A1 (enExample) |
| JP (1) | JP7100362B2 (enExample) |
| KR (1) | KR20180097542A (enExample) |
| CN (1) | CN108834415B (enExample) |
| AU (1) | AU2016354661B2 (enExample) |
| BR (1) | BR112018009550A2 (enExample) |
| CA (1) | CA3004680A1 (enExample) |
| IL (1) | IL259214B (enExample) |
| WO (1) | WO2017081483A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110769830A (zh) * | 2017-05-12 | 2020-02-07 | 马瓦隆治疗有限公司 | 作为ii组代谢型谷氨酸受体的别构调节剂的取代的杂环化合物 |
| CN108084187A (zh) * | 2017-12-15 | 2018-05-29 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类氢化物 |
| CN108003164A (zh) * | 2017-12-15 | 2018-05-08 | 宜昌人福药业有限责任公司 | 苯并二氮杂*类化合物 |
| WO2020223701A1 (en) * | 2019-05-02 | 2020-11-05 | The Broad Institute, Inc. | Methods for treating neurodevelopmental disorders |
| CN110172068A (zh) * | 2019-06-05 | 2019-08-27 | 河南龙湖生物技术有限公司 | 具有抗肿瘤活性的苯并噻唑类化合物及其制备方法和应用 |
| WO2021226208A2 (en) | 2020-05-05 | 2021-11-11 | Nuvalent, Inc. | Heteroaromatic macrocyclic ether chemotherapeutic agents |
| KR102698413B1 (ko) | 2020-05-05 | 2024-08-26 | 뉴베일런트, 아이엔씨. | 헤테로방향족 거대환식 에터 화학치료제 |
| TW202320768A (zh) | 2021-10-01 | 2023-06-01 | 美商努法倫特公司 | 雜芳族大環醚化合物之固體形式、醫藥組成物及製備 |
| WO2026006700A1 (en) * | 2024-06-28 | 2026-01-02 | Regents Of The University Of Michigan | Pyrrolo[1,2-a]-azocine analogues as iap antagonists |
| CN118993997A (zh) * | 2024-10-23 | 2024-11-22 | 浙江雅辰药物科技股份有限公司 | 一种3-溴-2-苯基吡啶的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4130716A (en) | 1977-03-07 | 1978-12-19 | Hoffmann-La Roche Inc. | Pyrazolo benzodiazepines |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| DE3169595D1 (en) | 1980-11-10 | 1985-05-02 | Gersonde Klaus | Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| EP0088046B1 (de) | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
| DE3218121A1 (de) | 1982-05-14 | 1983-11-17 | Leskovar, Peter, Dr.-Ing., 8000 München | Arzneimittel zur tumorbehandlung |
| EP0102324A3 (de) | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipide und Tenside in wässriger Phase |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| DE3486459D1 (de) | 1983-09-26 | 1997-12-11 | Udo Dr Med Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
| EP0143949B1 (en) | 1983-11-01 | 1988-10-12 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Pharmaceutical composition containing urokinase |
| FI880814A7 (fi) | 1987-03-10 | 1988-09-11 | Hoffmann La Roche | Imidazodiazepin-derivat. |
| MX2009007053A (es) | 2006-12-28 | 2009-07-09 | Abbott Lab | Inhibidores de poli (adp-ribosa) polimerasa. |
| US10059671B2 (en) | 2013-02-04 | 2018-08-28 | Prexton Therapeutics Sa | Positive allosteric modulators of mGluR3 |
-
2016
- 2016-11-11 CA CA3004680A patent/CA3004680A1/en not_active Abandoned
- 2016-11-11 AU AU2016354661A patent/AU2016354661B2/en not_active Ceased
- 2016-11-11 JP JP2018544438A patent/JP7100362B2/ja not_active Expired - Fee Related
- 2016-11-11 EP EP16797625.7A patent/EP3374360A1/en not_active Withdrawn
- 2016-11-11 KR KR1020187016380A patent/KR20180097542A/ko not_active Ceased
- 2016-11-11 CN CN201680078195.9A patent/CN108834415B/zh not_active Expired - Fee Related
- 2016-11-11 WO PCT/GB2016/053550 patent/WO2017081483A1/en not_active Ceased
- 2016-11-11 BR BR112018009550A patent/BR112018009550A2/pt not_active Application Discontinuation
- 2016-11-11 US US15/775,725 patent/US11008323B2/en not_active Expired - Fee Related
-
2018
- 2018-05-08 IL IL259214A patent/IL259214B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20180346468A1 (en) | 2018-12-06 |
| JP2019504108A (ja) | 2019-02-14 |
| EP3374360A1 (en) | 2018-09-19 |
| JP7100362B2 (ja) | 2022-07-13 |
| AU2016354661B2 (en) | 2020-12-10 |
| IL259214B (en) | 2021-09-30 |
| CA3004680A1 (en) | 2017-05-18 |
| CN108834415B (zh) | 2021-12-24 |
| IL259214A (en) | 2018-07-31 |
| AU2016354661A1 (en) | 2018-06-07 |
| KR20180097542A (ko) | 2018-08-31 |
| US11008323B2 (en) | 2021-05-18 |
| WO2017081483A1 (en) | 2017-05-18 |
| CN108834415A (zh) | 2018-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B25G | Requested change of headquarter approved |
Owner name: MAVALON THERAPEUTICS LIMITED (GB) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B25C | Requirement related to requested transfer of rights |
Owner name: MAVALON THERAPEUTICS LIMITED (GB) Free format text: A FIM DE ATENDER A TRANSFERENCIA, REQUERIDA ATRAVES DA PETICAO NO 870210045259 DE 19/05/2021, E NECESSARIO APRESENTAR O DOCUMENTO DE CESSAO DEVIDAMENTE NOTARIZADO, ALEM DA GUIA DE CUMPRIMENTO DE EXIGENCIA. |
|
| B25B | Requested transfer of rights rejected |
Owner name: MAVALON THERAPEUTICS LIMITED (GB) Free format text: INDEFERIDO O PEDIDO DE TRANSFERENCIA CONTIDO NA PETICAO 870210045259 DE 19/05/2021, POR AUSENCIA DE CUMPRIMENTO DA EXIGENCIA PUBLICADA NA RPI NO 2649, DE 13/10/2021. |
|
| B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: MAVALON THERAPEUTICS LIMITED (GB) Free format text: ANULADA A PUBLICACAO CODIGO 25.2 NA RPI NO 2665 DE 01/02/2022 POR TER SIDO INDEVIDA. |
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| B25A | Requested transfer of rights approved |
Owner name: DOMAIN THERAPEUTICS (FR) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |