BR112018009463A8 - ensaios e métodos para selecionar um regime de tratamento para um sujeito com leucemia - Google Patents
ensaios e métodos para selecionar um regime de tratamento para um sujeito com leucemiaInfo
- Publication number
- BR112018009463A8 BR112018009463A8 BR112018009463A BR112018009463A BR112018009463A8 BR 112018009463 A8 BR112018009463 A8 BR 112018009463A8 BR 112018009463 A BR112018009463 A BR 112018009463A BR 112018009463 A BR112018009463 A BR 112018009463A BR 112018009463 A8 BR112018009463 A8 BR 112018009463A8
- Authority
- BR
- Brazil
- Prior art keywords
- trials
- methods
- selecting
- treatment regimen
- cpx
- Prior art date
Links
- 208000032839 leukemia Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000011269 treatment regimen Methods 0.000 title 1
- 101100335081 Mus musculus Flt3 gene Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000011284 combination treatment Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Abstract
a presente invenção refere-se a métodos diagnósticos para identificar sujeitos que possuem câncer apropriados para o tratamento com cpx 351 que incluem testes genéticos e ex vivo de células de um sujeito candidato. o tratamento de combinação com inibidores de flt 3 e cpx 351 melhora a toxicidade e absorção de cpx 351.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562254109P | 2015-11-11 | 2015-11-11 | |
PCT/US2016/061444 WO2017083592A1 (en) | 2015-11-11 | 2016-11-10 | Assays and methods for selecting a treatment regimen for a subject with leukemia |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018009463A2 BR112018009463A2 (pt) | 2018-11-06 |
BR112018009463A8 true BR112018009463A8 (pt) | 2019-02-26 |
Family
ID=58695625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018009463A BR112018009463A8 (pt) | 2015-11-11 | 2016-11-10 | ensaios e métodos para selecionar um regime de tratamento para um sujeito com leucemia |
Country Status (15)
Country | Link |
---|---|
US (3) | US10927418B2 (pt) |
EP (1) | EP3373919A4 (pt) |
JP (2) | JP6976941B2 (pt) |
KR (1) | KR20180108572A (pt) |
CN (2) | CN108778260A (pt) |
AU (2) | AU2016353163B2 (pt) |
BR (1) | BR112018009463A8 (pt) |
CA (2) | CA3005076C (pt) |
CO (1) | CO2018005846A2 (pt) |
HK (1) | HK1258724A1 (pt) |
IL (2) | IL292080A (pt) |
MX (1) | MX2018005771A (pt) |
MY (1) | MY193531A (pt) |
SG (2) | SG11201804020YA (pt) |
WO (1) | WO2017083592A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3005076C (en) * | 2015-11-11 | 2024-01-02 | Celator Pharmaceuticals, Inc. | Assays and methods for selecting a treatment regimen for a subject with leukemia |
CA3114002A1 (en) * | 2018-09-25 | 2020-04-02 | Celator Pharmaceuticals, Inc. | Low-intensity treatment of hematological disorders |
WO2020102595A1 (en) * | 2018-11-14 | 2020-05-22 | Dana-Farber Cancer Institute, Inc. | Determining treatment response in single cells |
CN111870600B (zh) * | 2020-07-13 | 2022-04-15 | 中南大学湘雅二医院 | 索拉非尼、瑞戈非尼及其类似物或衍生物的新应用 |
WO2023129667A1 (en) | 2021-12-30 | 2023-07-06 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2407169A1 (en) | 2004-04-22 | 2012-01-18 | Celator Pharmaceuticals, Inc. | Combination formulations of anthracycline agents and cytidine analogs |
PL2120568T3 (pl) | 2007-02-16 | 2018-03-30 | Celator Pharmaceuticals, Inc. | Stały stosunek leków w leczeniu krwiotwórczych nowotworów i chorób proliferacyjnych |
TW200901975A (en) | 2007-03-05 | 2009-01-16 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
TWI546537B (zh) * | 2009-05-19 | 2016-08-21 | 維維亞生技公司 | 提供針對血液腫瘤之體外個人化藥物測試之方法 |
US20120010229A1 (en) * | 2010-07-08 | 2012-01-12 | Macdougall John R | Therapeutic regimens for hedgehog-associated cancers |
JP6133308B2 (ja) * | 2011-10-21 | 2017-05-24 | セレーター ファーマシューティカルズ インコーポレイテッド | 凍結乾燥リポソーム |
WO2014087018A1 (en) * | 2012-12-07 | 2014-06-12 | Evotec (München) Gmbh | Markers for responsiveness to an inhibitor of flt3 |
EP3191126B1 (en) * | 2014-09-13 | 2020-05-13 | Novartis AG | Combination therapies of alk inhibitors |
CA3005076C (en) * | 2015-11-11 | 2024-01-02 | Celator Pharmaceuticals, Inc. | Assays and methods for selecting a treatment regimen for a subject with leukemia |
CA3114002A1 (en) * | 2018-09-25 | 2020-04-02 | Celator Pharmaceuticals, Inc. | Low-intensity treatment of hematological disorders |
-
2016
- 2016-11-10 CA CA3005076A patent/CA3005076C/en active Active
- 2016-11-10 IL IL292080A patent/IL292080A/en unknown
- 2016-11-10 BR BR112018009463A patent/BR112018009463A8/pt not_active Application Discontinuation
- 2016-11-10 CA CA3219061A patent/CA3219061A1/en active Pending
- 2016-11-10 WO PCT/US2016/061444 patent/WO2017083592A1/en active Application Filing
- 2016-11-10 CN CN201680078494.2A patent/CN108778260A/zh active Pending
- 2016-11-10 AU AU2016353163A patent/AU2016353163B2/en active Active
- 2016-11-10 SG SG11201804020YA patent/SG11201804020YA/en unknown
- 2016-11-10 EP EP16865052.1A patent/EP3373919A4/en active Pending
- 2016-11-10 MY MYPI2018000723A patent/MY193531A/en unknown
- 2016-11-10 CN CN202211111497.5A patent/CN115414376A/zh active Pending
- 2016-11-10 US US15/774,978 patent/US10927418B2/en active Active
- 2016-11-10 SG SG10202112699UA patent/SG10202112699UA/en unknown
- 2016-11-10 MX MX2018005771A patent/MX2018005771A/es unknown
- 2016-11-10 JP JP2018525429A patent/JP6976941B2/ja active Active
- 2016-11-10 KR KR1020187016563A patent/KR20180108572A/ko not_active Application Discontinuation
-
2018
- 2018-05-10 IL IL259271A patent/IL259271B/en unknown
- 2018-06-06 CO CONC2018/0005846A patent/CO2018005846A2/es unknown
-
2019
- 2019-01-22 HK HK19101125.5A patent/HK1258724A1/zh unknown
-
2021
- 2021-02-11 US US17/173,677 patent/US11746386B2/en active Active
- 2021-11-10 JP JP2021183443A patent/JP2022024031A/ja active Pending
-
2022
- 2022-12-22 AU AU2022291559A patent/AU2022291559A1/en active Pending
-
2023
- 2023-05-12 US US18/316,719 patent/US20230279503A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20230279503A1 (en) | 2023-09-07 |
AU2022291559A1 (en) | 2023-02-02 |
BR112018009463A2 (pt) | 2018-11-06 |
US20210246512A1 (en) | 2021-08-12 |
KR20180108572A (ko) | 2018-10-04 |
US10927418B2 (en) | 2021-02-23 |
US20180327854A1 (en) | 2018-11-15 |
JP6976941B2 (ja) | 2021-12-08 |
CN115414376A (zh) | 2022-12-02 |
CA3005076C (en) | 2024-01-02 |
HK1258724A1 (zh) | 2019-11-15 |
AU2016353163A1 (en) | 2018-06-07 |
EP3373919A4 (en) | 2019-06-19 |
MX2018005771A (es) | 2019-03-14 |
AU2016353163B2 (en) | 2022-09-29 |
CN108778260A (zh) | 2018-11-09 |
US11746386B2 (en) | 2023-09-05 |
IL259271B (en) | 2022-05-01 |
SG10202112699UA (en) | 2021-12-30 |
SG11201804020YA (en) | 2018-06-28 |
CA3219061A1 (en) | 2017-05-18 |
CO2018005846A2 (es) | 2018-08-21 |
WO2017083592A1 (en) | 2017-05-18 |
EP3373919A1 (en) | 2018-09-19 |
CA3005076A1 (en) | 2017-05-18 |
JP2018535975A (ja) | 2018-12-06 |
IL292080A (en) | 2022-06-01 |
JP2022024031A (ja) | 2022-02-08 |
RU2018121249A3 (pt) | 2020-03-17 |
IL259271A (en) | 2018-07-31 |
MY193531A (en) | 2022-10-18 |
RU2018121249A (ru) | 2019-12-17 |
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