ES2811835T3 - Procedimiento para determinar el riesgo de toxicidad por 5-fluorouracilo - Google Patents

Procedimiento para determinar el riesgo de toxicidad por 5-fluorouracilo Download PDF

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Publication number
ES2811835T3
ES2811835T3 ES15709982T ES15709982T ES2811835T3 ES 2811835 T3 ES2811835 T3 ES 2811835T3 ES 15709982 T ES15709982 T ES 15709982T ES 15709982 T ES15709982 T ES 15709982T ES 2811835 T3 ES2811835 T3 ES 2811835T3
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Prior art keywords
risk
procedure
determining
subject
polymorphism
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ES15709982T
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English (en)
Inventor
David Kerr
Ian Tomlinson
Dan Rosmarin
Claire Palles
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Oxford University Innovation Ltd
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Oxford University Innovation Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

Un procedimiento de detección del riesgo de toxicidad por 5-fluorouracilo (FU) en un sujeto, que comprende la detección en el sujeto de la presencia del polimorfismo de TYMS rs2612091; en el que: i. la presencia de dicho polimorfismo indica un mayor riesgo de desarrollar toxicidad por FU en comparación con un sujeto que no posee dicho polimorfismo; y ii. un resultado negativo indica un menor riesgo de desarrollar toxicidad por FU en comparación con un sujeto que posee dicho polimorfismo.
ES15709982T 2014-03-04 2015-03-02 Procedimiento para determinar el riesgo de toxicidad por 5-fluorouracilo Active ES2811835T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1403820.2A GB201403820D0 (en) 2014-03-04 2014-03-04 Assay
PCT/GB2015/050597 WO2015132569A1 (en) 2014-03-04 2015-03-02 Method of determining risk of 5-fluorouracil toxicity

Publications (1)

Publication Number Publication Date
ES2811835T3 true ES2811835T3 (es) 2021-03-15

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Family Applications (1)

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ES15709982T Active ES2811835T3 (es) 2014-03-04 2015-03-02 Procedimiento para determinar el riesgo de toxicidad por 5-fluorouracilo

Country Status (7)

Country Link
US (1) US10774385B2 (es)
EP (1) EP3114235B1 (es)
CN (1) CN106460037B (es)
DK (1) DK3114235T3 (es)
ES (1) ES2811835T3 (es)
GB (1) GB201403820D0 (es)
WO (1) WO2015132569A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105567811A (zh) * 2015-12-30 2016-05-11 广州金域检测科技股份有限公司 一种dpyd基因多态性的引物及其检测方法
CN105463100A (zh) * 2015-12-30 2016-04-06 广州金域检测科技股份有限公司 一种dpyd*13基因多态性的引物及其检测方法
CN105463098A (zh) * 2015-12-30 2016-04-06 广州金域检测科技股份有限公司 一种dpyd*9b基因多态性的引物及其检测方法
CN105463099A (zh) * 2015-12-30 2016-04-06 广州金域检测科技股份有限公司 一种dpyd*9a基因多态性的引物及其检测方法
JP6612662B2 (ja) * 2016-03-16 2019-11-27 株式会社東芝 リチウムイオン二次電池用負極活物質、リチウムイオン二次電池用負極、リチウムイオン二次電池、電池パック及び車両
CN107194206A (zh) * 2017-06-26 2017-09-22 思畅信息科技（上海）有限公司 一种基于大数据的染色体异常位点的筛选方法
CN107400714B (zh) * 2017-08-21 2020-12-29 广州永诺生物科技有限公司 结直肠癌用药相关基因检测的多重pcr引物组和试剂盒
CN109295171A (zh) * 2018-10-22 2019-02-01 北京华夏时代生物工程有限公司 用于荧光原位杂交测序检测snp的核苷酸分子组合及应用
CN109337984A (zh) * 2018-12-14 2019-02-15 北京华夏时代基因科技发展有限公司 用于氟尿嘧啶代谢相关基因snp检测的核苷酸分子组合
GB202112296D0 (en) * 2021-08-27 2021-10-13 Univ Oxford Innovation Ltd Assay

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09507121A (ja) * 1993-10-26 1997-07-22 アフィマックス テクノロジーズ ナームロゼ ベノートスハップ 生物学的チップ上の核酸プローブアレー
US20060051764A1 (en) * 2002-10-21 2006-03-09 Michael Mandola Thymidylate synthase polymorphisms for use in screening for cancer susceptibility
US20100240548A1 (en) * 2008-12-11 2010-09-23 Moritz Eidens Genotyping Dihydropyrimidine Dehydrogenase Deficiency
AU2010265889A1 (en) * 2009-06-25 2012-01-19 Yale University Single nucleotide polymorphisms in BRCA1 and cancer risk
CA3080511C (en) * 2009-08-21 2022-05-24 Novartis Ag Use of lapatinib for treating cancer
EP2847593A4 (en) * 2012-05-11 2016-01-13 Hutchinson Fred Cancer Res METHODS FOR PREDICTING AND DETECTING THE RISK OF CANCER

Also Published As

Publication number Publication date
CN106460037B (zh) 2020-06-05
EP3114235B1 (en) 2020-05-13
WO2015132569A1 (en) 2015-09-11
US10774385B2 (en) 2020-09-15
DK3114235T3 (da) 2020-06-22
US20170073765A1 (en) 2017-03-16
GB201403820D0 (en) 2014-04-16
CN106460037A (zh) 2017-02-22
EP3114235A1 (en) 2017-01-11

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