RU2018121249A - Анализы и способы для выбора схемы лечения для индивидуума с лейкозом - Google Patents

Анализы и способы для выбора схемы лечения для индивидуума с лейкозом Download PDF

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RU2018121249A
RU2018121249A RU2018121249A RU2018121249A RU2018121249A RU 2018121249 A RU2018121249 A RU 2018121249A RU 2018121249 A RU2018121249 A RU 2018121249A RU 2018121249 A RU2018121249 A RU 2018121249A RU 2018121249 A RU2018121249 A RU 2018121249A
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Макс ГОРДОН
Пол ТАРДИ
Джеффри ТАЙНЕР
Лоренс МАЙЕР
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Селатор Фармасьютикалз, Инк.
Орегон Хэлт Энд Сайенс Юниверсити
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Claims (21)

1. Комбинация CPX-351 и ингибитора FLT-3 для применения в способе лечения гемобластоза у индивидуума с гемобластозом,
включающем введение эффективного количества указанной комбинации CPX-351 и ингибитора FLT-3.
2. Комбинация по п.1, где указанный индивидуум имеет мутацию гена Fms-подобной рецепторной тирозинкиназы 3 (FLT-3).
3. Комбинация по п.2, где мутация является активирующей мутацией гена FLT-3.
4. Комбинация по п.1, где в указанном способе ингибитор CPX-351 и FLT-3 вводят одновременно, или где CPX-351 вводят перед лечением ингибитором FLT-3, или где CPX-351 и ингибитор FLT-3 вводят в одной композиции.
5. Комбинация по п.1, где гемобластоз выбран из группы, состоящей из острого миелогенного лейкоза (AML), острого лимфоцитарного лейкоза (ALL), хронического лимфоцитарного лейкоза (CLL), хронического миелолейкоза (CML), миелопролиферативных неоплазий (MPN) и лимфом.
6. Комбинация по любому из пп.1-5, где ингибитором FLT-3 является квизартиниб, мидостаурин, тандутиниб, сорафениб, сунитиниб, лестауртиниб, креноланиб, гилтеритиниб, AST-487, довитиниб или линифаниб.
7. CPX-351 для применения в способе лечения гемобластоза у индивидуума, включающем:
(a) определение наличия или отсутствия мутации гена Fms-подобной рецепторной тирозинкиназы 3 (FLT-3) у указанного индивидуума и введение эффективного количества CPX-351 индивидууму, имеющему мутацию указанного гена FLT-3;и/или
(b) определение наличия или отсутствия мутации гена нуклеофозмина 1 (NPM-1) у указанного индивидуума и введение эффективного количества CPX-351 индивидууму, имеющему мутацию указанного гена NPM-1;и/или
(c) определение наличия или отсутствия мутации гена CCAAT-энхансерного связывающего белка альфа (CEBPα) у указанного индивидуума и введение эффективного количества CPX-351 индивидууму, имеющему мутацию указанного гена CEBPα; и/или
(d) определение генотипа указанного индивидуума, как имеющего благоприятный риск, промежуточный-I, промежуточный-II или неблагоприятный риск, и введение терапевтически эффективного количества CPX-351 индивидууму, генотип которого соответствует неблагоприятному риску или промежуточному-II.
8. Способ определения восприимчивости человека с гемобластозом к лечению CPX-351, включающий анализ биологического образца указанного индивидуума для определения:
a) наличия или отсутствия мутации гена Fms-подобной рецепторной тирозинкиназы 3 (FLT-3) у указанного индивидуума; и/или
b) наличия или отсутствия мутации гена нуклеофозмина 1 (NPM-1) у указанного индивидуума; и/или
c) наличия или отсутствия мутации гена CCAAT-энхансерного связывающего белка альфа (CEBPα) у указанного индивидуума; и/или
d) генотипа указанного индивидуума, как имеющего благоприятный риск, промежуточный-I, промежуточный-II или неблагоприятный риск.
9. Способ по п. 8, где гемобластоз выбран из группы, состоящей из острого миелогенного лейкоза (AML), острого лимфоцитарного лейкоза (ALL), хронического лимфоцитарного лейкоза (CLL), хронического миелолейкоза (CML), миелопролиферативных неоплазий (MPN) и лимфом.
10. Способ по п.8, где мутация (a) является активирующей мутацией FLT-3.
11. Способ по п.10, где мутация является мутацией FLT-3-ITD или FLT-3-TKD.
12. Способ по любому из пп.8-11, где биологический образец содержит кровь, сыворотку, плазму, слюну или бластные клетки.
RU2018121249A 2015-11-11 2016-11-10 Анализы и способы для выбора схемы лечения для индивидуума с лейкозом RU2786077C2 (ru)

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PCT/US2016/061444 WO2017083592A1 (en) 2015-11-11 2016-11-10 Assays and methods for selecting a treatment regimen for a subject with leukemia

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