BR112018008448A2 - ?método para produzir um composto? - Google Patents

?método para produzir um composto?

Info

Publication number
BR112018008448A2
BR112018008448A2 BR112018008448-4A BR112018008448A BR112018008448A2 BR 112018008448 A2 BR112018008448 A2 BR 112018008448A2 BR 112018008448 A BR112018008448 A BR 112018008448A BR 112018008448 A2 BR112018008448 A2 BR 112018008448A2
Authority
BR
Brazil
Prior art keywords
dimethoxybenzyl
machine
dimethoxybenzyl group
dimethoxybenzylation
compound
Prior art date
Application number
BR112018008448-4A
Other languages
English (en)
Japanese (ja)
Inventor
Kadota Kohei
Ueda Tsuyoshi
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of BR112018008448A2 publication Critical patent/BR112018008448A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
    • C07D277/52—Nitrogen atoms bound to hetero atoms to sulfur atoms, e.g. sulfonamides

Abstract

em um método para produzir um composto de de-dimetoxibenzilação que remove um grupo dimetoxibenzila, na presença de um ácido, a partir de um composto, em que o grupo dimetoxibenzila é ligado a um átomo de nitrogênio, um composto de de-dimetoxibenzilação é obtido por remoção de um grupo dimetoxibenzila sem produzir um produto fracamente solúvel a partir do grupo dimetoxibenzila removido. a reação de de-dimetoxibenzilação é realizada na presença de trifenilfosfina ou dietil tioureia.
BR112018008448-4A 2015-11-06 2016-11-04 ?método para produzir um composto? BR112018008448A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2015218355 2015-11-06
JP2015-218355 2015-11-06
PCT/JP2016/082752 WO2017078123A1 (ja) 2015-11-06 2016-11-04 ジメトキシベンジル基の脱離方法

Publications (1)

Publication Number Publication Date
BR112018008448A2 true BR112018008448A2 (pt) 2018-11-06

Family

ID=58662039

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008448-4A BR112018008448A2 (pt) 2015-11-06 2016-11-04 ?método para produzir um composto?

Country Status (11)

Country Link
US (1) US10316026B2 (pt)
EP (1) EP3372583A4 (pt)
JP (1) JPWO2017078123A1 (pt)
KR (1) KR20180080187A (pt)
CN (1) CN108349894A (pt)
BR (1) BR112018008448A2 (pt)
CA (1) CA3002920A1 (pt)
HK (1) HK1252869A1 (pt)
IL (1) IL259144A (pt)
TW (1) TW201722894A (pt)
WO (1) WO2017078123A1 (pt)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004091514A2 (en) * 2003-04-15 2004-10-28 Merck & Co., Inc. Cgrp receptor antagonists
CN101090902B (zh) * 2004-10-13 2013-05-29 默沙东公司 Cgrp受体拮抗剂
DK2385938T3 (en) 2009-01-12 2015-04-27 Pfizer Ltd Sulfonamidderivater
JP5830534B2 (ja) 2010-07-09 2015-12-09 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 化合物
EP2744805A1 (en) * 2011-08-17 2014-06-25 Amgen Inc. Heteroaryl sodium channel inhibitors
KR20140091022A (ko) 2011-10-31 2014-07-18 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
US8889741B2 (en) 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives
WO2014066490A1 (en) * 2012-10-26 2014-05-01 Merck Sharp & Dohme Corp. Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
CN105073114B (zh) * 2013-03-14 2017-07-28 第一三共株式会社 用于呼吸疾病的药物
CN104447234A (zh) * 2014-12-08 2015-03-25 安徽万邦医药科技有限公司 (3r,4r)-4-(3,4-二甲氧基苄基)-3-(4-羟基-3-甲氧基苄基)-二氢呋喃的制备方法

Also Published As

Publication number Publication date
WO2017078123A1 (ja) 2017-05-11
TW201722894A (zh) 2017-07-01
US10316026B2 (en) 2019-06-11
HK1252869A1 (zh) 2019-06-06
CN108349894A (zh) 2018-07-31
JPWO2017078123A1 (ja) 2018-09-13
IL259144A (en) 2018-06-28
CA3002920A1 (en) 2017-05-11
KR20180080187A (ko) 2018-07-11
EP3372583A4 (en) 2019-06-05
EP3372583A1 (en) 2018-09-12
US20180251448A1 (en) 2018-09-06

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]