BR112018007159A2 - formulações de análogos de pthrp, emplastros transdérmicos dos mesmos e usos dos mesmos - Google Patents
formulações de análogos de pthrp, emplastros transdérmicos dos mesmos e usos dos mesmosInfo
- Publication number
- BR112018007159A2 BR112018007159A2 BR112018007159A BR112018007159A BR112018007159A2 BR 112018007159 A2 BR112018007159 A2 BR 112018007159A2 BR 112018007159 A BR112018007159 A BR 112018007159A BR 112018007159 A BR112018007159 A BR 112018007159A BR 112018007159 A2 BR112018007159 A2 BR 112018007159A2
- Authority
- BR
- Brazil
- Prior art keywords
- formulations
- bone
- transdermal patches
- pthrp
- pthrp analog
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 5
- 101150071808 PTHLH gene Proteins 0.000 title abstract 3
- 208000010392 Bone Fractures Diseases 0.000 abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000029725 Metabolic bone disease Diseases 0.000 abstract 1
- 206010049088 Osteopenia Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
a presente invenção refere-se a formulações análogas pthrp para a administração transdérmica de uma quantidade terapeuticamente eficaz de um análogo pthrp bem como emplastros transdérmicos preparados usando estas formulações, métodos para preparar as formulações de acordo com a invenção e emplastros e métodos para usar estas formulações e emplastros para tratar osteoporose, osteopenia, osteoartrite e/ou fratura óssea , melhorar a densidade mineral óssea (dmo), para melhorar a pontuação do osso trabecular (tbs) e tratar, prevenir e/ou reduzir fraturas ósseas.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562239801P | 2015-10-09 | 2015-10-09 | |
US201562239774P | 2015-10-09 | 2015-10-09 | |
US201562239773P | 2015-10-09 | 2015-10-09 | |
US201662324336P | 2016-04-18 | 2016-04-18 | |
US201662353249P | 2016-06-22 | 2016-06-22 | |
US201662396196P | 2016-09-18 | 2016-09-18 | |
PCT/US2016/056196 WO2017062922A1 (en) | 2015-10-09 | 2016-10-08 | Formulations of pthrp analogues, transdermal patches thereof, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018007159A2 true BR112018007159A2 (pt) | 2018-11-06 |
Family
ID=58488710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018007159A BR112018007159A2 (pt) | 2015-10-09 | 2016-10-08 | formulações de análogos de pthrp, emplastros transdérmicos dos mesmos e usos dos mesmos |
Country Status (22)
Country | Link |
---|---|
US (1) | US20190091138A1 (pt) |
EP (2) | EP3359241B1 (pt) |
JP (3) | JP6867379B2 (pt) |
KR (1) | KR20180067573A (pt) |
CN (2) | CN115025068A (pt) |
AU (2) | AU2016334378B2 (pt) |
BR (1) | BR112018007159A2 (pt) |
CA (1) | CA3000533C (pt) |
CY (1) | CY1124657T1 (pt) |
DK (1) | DK3359241T3 (pt) |
ES (1) | ES2881461T3 (pt) |
HR (1) | HRP20211127T1 (pt) |
HU (1) | HUE055658T2 (pt) |
IL (2) | IL287604B2 (pt) |
LT (1) | LT3359241T (pt) |
MX (1) | MX2018004192A (pt) |
PL (1) | PL3359241T3 (pt) |
PT (1) | PT3359241T (pt) |
RS (1) | RS62394B1 (pt) |
SG (1) | SG11201802871UA (pt) |
SI (1) | SI3359241T1 (pt) |
WO (1) | WO2017062922A1 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016141250A1 (en) * | 2015-03-03 | 2016-09-09 | Radius Health, Inc. | USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK |
US10568937B2 (en) | 2016-04-18 | 2020-02-25 | Radius Health, Inc. | Formulations of abaloparatide, transdermal patches thereof, and uses thereof |
US10996208B2 (en) | 2017-04-28 | 2021-05-04 | Radius Health, Inc. | Abaloparatide formulations and methods of testing, storing, modifying, and using same |
CA3075984A1 (en) * | 2017-09-22 | 2019-03-28 | Asahi Kasei Pharma Corporation | Teriparatide-containing liquid pharmaceutical composition having excellent pharmacokinetics and/or safety |
CN107674113A (zh) * | 2017-10-20 | 2018-02-09 | 广东医科大学 | 一种小分子活性肽及其制备方法、及采用该活性肽的透皮贴剂的制备方法与其用途 |
CN110054679B (zh) * | 2018-01-18 | 2021-05-04 | 成都圣诺生物制药有限公司 | 一种合成Abaloparatide的方法 |
CN109602911B (zh) * | 2019-01-09 | 2020-11-10 | 厦门大学 | 硫酸钙晶须或其组合物在制备皮肤促渗剂中的用途 |
SG11202106205YA (en) | 2019-02-28 | 2021-07-29 | Radius Health Inc | Transdermal system for the delivery of abaloparatide and method of use |
CN114364327A (zh) * | 2019-09-12 | 2022-04-15 | 雷迪厄斯健康公司 | 用阿巴帕肽改善脊柱融合的方法 |
EP4110371A1 (en) | 2020-01-24 | 2023-01-04 | Radius Health, Inc. | Methods of stimulating bone growth with abalopartide and denosumab |
US12029562B2 (en) | 2021-04-14 | 2024-07-09 | Satio, Inc. | Dermal patch system |
US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
US20220378881A1 (en) * | 2021-05-25 | 2022-12-01 | Radius Health, Inc. | Treatment and prevention of osteoporosis in high body mass index individuals |
WO2023281447A1 (en) | 2021-07-07 | 2023-01-12 | Radius Health, Inc. | Methods of treating a cardiovascular ischemic event |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005014034A1 (en) * | 2003-07-14 | 2005-02-17 | Nps Allelix Corp. | Stabilized formulation of parathyroid hormone |
WO2007106597A2 (en) * | 2006-03-15 | 2007-09-20 | Alza Corporation | Method for the transdermal delivery of parathyroid hormone agents for treating osteopenia |
DK2957278T3 (en) * | 2006-10-03 | 2017-07-31 | Radius Health Inc | STABLE COMPOSITION COMPREHENSIVE PTHRP AND APPLICATIONS THEREOF |
WO2009054988A1 (en) * | 2007-10-23 | 2009-04-30 | Alza Corporation | Transdermal sustained release drug delivery |
US8563513B2 (en) * | 2009-03-27 | 2013-10-22 | Van Andel Research Institute | Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use |
WO2011105508A1 (ja) * | 2010-02-24 | 2011-09-01 | 久光製薬株式会社 | マイクロニードルデバイス及びその製造方法 |
US8637458B2 (en) * | 2010-05-12 | 2014-01-28 | Biodel Inc. | Insulin with a stable basal release profile |
AU2012245301B2 (en) * | 2011-04-22 | 2016-05-19 | 3M Innovative Properties Company, A Wholly Owned Subsidiary Of 3M Company | Method of drug delivery for PTH, PTHrP and related peptides |
CN104080441B (zh) * | 2011-11-30 | 2020-02-28 | 3M创新有限公司 | 包括肽治疗剂和氨基酸的微针装置、制备和使用其的方法 |
CN102526220A (zh) * | 2012-01-10 | 2012-07-04 | 上海市中医医院 | 一种治疗期前收缩的中药贴剂及其制备方法和应用 |
US9581438B2 (en) * | 2012-12-31 | 2017-02-28 | General Electric Company | Systems and methods for control of a non-destructive testing system |
MX2020009878A (es) * | 2013-07-18 | 2022-07-27 | Mannkind Corp | Composiciones farmaceuticas en polvo seco estables al calor y metodos. |
US10905744B2 (en) * | 2015-10-07 | 2021-02-02 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
-
2016
- 2016-10-08 WO PCT/US2016/056196 patent/WO2017062922A1/en active Application Filing
- 2016-10-08 PL PL16854524T patent/PL3359241T3/pl unknown
- 2016-10-08 EP EP16854524.2A patent/EP3359241B1/en active Active
- 2016-10-08 AU AU2016334378A patent/AU2016334378B2/en active Active
- 2016-10-08 KR KR1020187012690A patent/KR20180067573A/ko active Search and Examination
- 2016-10-08 JP JP2018517605A patent/JP6867379B2/ja active Active
- 2016-10-08 RS RS20210890A patent/RS62394B1/sr unknown
- 2016-10-08 SI SI201631273T patent/SI3359241T1/sl unknown
- 2016-10-08 IL IL287604A patent/IL287604B2/en unknown
- 2016-10-08 LT LTEP16854524.2T patent/LT3359241T/lt unknown
- 2016-10-08 CN CN202210139738.0A patent/CN115025068A/zh active Pending
- 2016-10-08 PT PT168545242T patent/PT3359241T/pt unknown
- 2016-10-08 CN CN201680064981.3A patent/CN108697881A/zh active Pending
- 2016-10-08 SG SG11201802871UA patent/SG11201802871UA/en unknown
- 2016-10-08 CA CA3000533A patent/CA3000533C/en active Active
- 2016-10-08 HU HUE16854524A patent/HUE055658T2/hu unknown
- 2016-10-08 BR BR112018007159A patent/BR112018007159A2/pt active Search and Examination
- 2016-10-08 ES ES16854524T patent/ES2881461T3/es active Active
- 2016-10-08 EP EP21167699.4A patent/EP3909566A1/en active Pending
- 2016-10-08 DK DK16854524.2T patent/DK3359241T3/da active
- 2016-10-08 MX MX2018004192A patent/MX2018004192A/es unknown
-
2018
- 2018-03-28 IL IL258441A patent/IL258441B/en unknown
- 2018-04-09 US US15/948,953 patent/US20190091138A1/en not_active Abandoned
-
2021
- 2021-04-08 JP JP2021065966A patent/JP7146011B2/ja active Active
- 2021-07-14 HR HRP20211127TT patent/HRP20211127T1/hr unknown
- 2021-07-14 CY CY20211100636T patent/CY1124657T1/el unknown
- 2021-11-17 AU AU2021269361A patent/AU2021269361A1/en not_active Abandoned
-
2022
- 2022-09-20 JP JP2022149175A patent/JP2022174274A/ja active Pending
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Legal Events
Date | Code | Title | Description |
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B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B25A | Requested transfer of rights approved |
Owner name: RADIUS HEALTH, INC. (US) ; KINDEVA DRUG DELIVERY L.P. (US) |
|
B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: RADIUS HEALTH, INC. (US) ; 3M INNOVATIVE PROPERTIES COMPANY (US) Free format text: ANULADA A PUBLICACAO CODIGO 25.1 NA RPI NO 2660 DE 28/12/2021 POR TER SIDO INDEVIDA. |
|
B25G | Requested change of headquarter approved |
Owner name: RADIUS HEALTH, INC. (US) ; 3M INNOVATIVE PROPERTIES COMPANY (US) |
|
B25A | Requested transfer of rights approved |
Owner name: RADIUS HEALTH, INC. (US) ; KINDEVA DRUG DELIVERY L.P. (US) |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] |