BR112018001317A2 - ?composto, composição farmacêutica, método para a inibição de pctk1, rock2, csnk1d, jnk1, jnk3, riok2 e/ou dyrk1b, para o tratamento de uma doença e para o tratamento de uma distúrbio? - Google Patents

?composto, composição farmacêutica, método para a inibição de pctk1, rock2, csnk1d, jnk1, jnk3, riok2 e/ou dyrk1b, para o tratamento de uma doença e para o tratamento de uma distúrbio?

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Publication number
BR112018001317A2
BR112018001317A2 BR112018001317-0A BR112018001317A BR112018001317A2 BR 112018001317 A2 BR112018001317 A2 BR 112018001317A2 BR 112018001317 A BR112018001317 A BR 112018001317A BR 112018001317 A2 BR112018001317 A2 BR 112018001317A2
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BR
Brazil
Prior art keywords
treatment
riok2
pctk1
csnk1d
dyrk1b
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BR112018001317-0A
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English (en)
Other versions
BR112018001317B1 (pt
Inventor
Yen Yun
Liou Jing-Ping
Pan Shiow-Lin
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Taipei Medical University
Yen Yun
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Publication date
Application filed by Taipei Medical University, Yen Yun filed Critical Taipei Medical University
Publication of BR112018001317A2 publication Critical patent/BR112018001317A2/pt
Publication of BR112018001317B1 publication Critical patent/BR112018001317B1/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

a presente invenção se refere aos novos compostos com baixa citotoxicidade para o bloqueio do sistema ubiquitinação-proteassoma em doenças. consequentemente, estes compostos podem ser utilizados no tratamento de distúrbios incluindo, mas não limitados aos cânceres, doenças neurodegenerativas, distúrbios inflamatórios, distúrbios autoimunes e distúrbios metabólicos.
BR112018001317-0A 2015-07-23 Composto e composição farmacêutica BR112018001317B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2015/041767 WO2017014788A1 (en) 2015-07-23 2015-07-23 Aminonapthoquinone compounds and pharmaceutical composition for blocking ubiquitination-proteasome system in diseases

Publications (2)

Publication Number Publication Date
BR112018001317A2 true BR112018001317A2 (pt) 2018-09-11
BR112018001317B1 BR112018001317B1 (pt) 2023-07-11

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CA2992981C (en) 2023-10-17
US20180319749A1 (en) 2018-11-08
AU2015402778A1 (en) 2018-03-08
NZ739867A (en) 2023-06-30
AU2015402778B2 (en) 2020-10-29
CN108135871B (zh) 2022-11-04
ES2917526T3 (es) 2022-07-08
TWI690506B (zh) 2020-04-11
US11919858B2 (en) 2024-03-05
WO2017014788A1 (en) 2017-01-26
JP6820313B2 (ja) 2021-01-27
EP3324954A1 (en) 2018-05-30
EP3324954A4 (en) 2019-03-06
DK3324954T3 (da) 2022-05-02
EP3324954B1 (en) 2022-03-09
US10577328B2 (en) 2020-03-03
TW201716372A (zh) 2017-05-16
JP2018529639A (ja) 2018-10-11
CA2992981A1 (en) 2017-01-26
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CN108135871A (zh) 2018-06-08
US20200148643A1 (en) 2020-05-14

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