BR112017025283A2 - derivado de bisamida de ácido carboxílico como agente estimulando a regeneração de tecidos e a recuperação da função de tecidos diminuídos - Google Patents
derivado de bisamida de ácido carboxílico como agente estimulando a regeneração de tecidos e a recuperação da função de tecidos diminuídosInfo
- Publication number
- BR112017025283A2 BR112017025283A2 BR112017025283-0A BR112017025283A BR112017025283A2 BR 112017025283 A2 BR112017025283 A2 BR 112017025283A2 BR 112017025283 A BR112017025283 A BR 112017025283A BR 112017025283 A2 BR112017025283 A2 BR 112017025283A2
- Authority
- BR
- Brazil
- Prior art keywords
- recovery
- agent
- acid bisamide
- carboxylic acid
- tissue
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title abstract 4
- -1 carboxylic acid bisamide derivative Chemical class 0.000 title abstract 2
- 238000011084 recovery Methods 0.000 title abstract 2
- 230000017423 tissue regeneration Effects 0.000 title abstract 2
- 230000003292 diminished effect Effects 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 2
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 2
- 208000006454 hepatitis Diseases 0.000 abstract 2
- 201000009104 prediabetes syndrome Diseases 0.000 abstract 2
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 208000008964 Chemical and Drug Induced Liver Injury Diseases 0.000 abstract 1
- 206010008909 Chronic Hepatitis Diseases 0.000 abstract 1
- 206010014561 Emphysema Diseases 0.000 abstract 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000011623 Obstructive Lung disease Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
a presente invenção refere-se ao campo da medicina e refere-se a um agente que estimula a regeneração tecidual e a recuperação da função diminuída dos tecidos e órgãos. um agente medicinal para o tratamento e/ou profilaxia de uma condição patológica selecionada a partir do grupo incluindo síndrome metabólica, tolerância à glicose prejudicada, hepatite, particularmente hepatite crônica e hepatite tóxica, fibrose pulmonar idiopática (ipf), enfisema pulmonar , doença pulmonar obstrutiva crônica (copd) e caquexia, particularmente como resultado da tolerância à glicose alterada, fibrose pulmonar, doença pulmonar obstrutiva crônica, câncer e outras doenças, é proposta sob a forma de um agente com base em treamide. o último é um derivado de bisamida do ácido dicarboxílico de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2015120055 | 2015-05-27 | ||
| RU2015120055A RU2647438C2 (ru) | 2015-05-27 | 2015-05-27 | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей |
| PCT/RU2016/050015 WO2016190785A1 (ru) | 2015-05-27 | 2016-05-26 | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017025283A2 true BR112017025283A2 (pt) | 2018-08-07 |
Family
ID=57393489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017025283-0A BR112017025283A2 (pt) | 2015-05-27 | 2016-05-26 | derivado de bisamida de ácido carboxílico como agente estimulando a regeneração de tecidos e a recuperação da função de tecidos diminuídos |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10076511B2 (pt) |
| EP (1) | EP3305286A4 (pt) |
| JP (1) | JP6700312B2 (pt) |
| KR (1) | KR102174191B1 (pt) |
| CN (1) | CN108024978B (pt) |
| AU (1) | AU2016266439B2 (pt) |
| BR (1) | BR112017025283A2 (pt) |
| CA (1) | CA2986911C (pt) |
| EA (1) | EA034437B1 (pt) |
| HK (1) | HK1247126A1 (pt) |
| IL (1) | IL255899B (pt) |
| MA (1) | MA45829A (pt) |
| MX (1) | MX2017015192A (pt) |
| RU (2) | RU2647438C2 (pt) |
| SG (1) | SG11201709654YA (pt) |
| UA (1) | UA122336C2 (pt) |
| WO (1) | WO2016190785A1 (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2647438C2 (ru) * | 2015-05-27 | 2018-03-15 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей |
| RU2662559C1 (ru) * | 2017-10-27 | 2018-07-26 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Новый ингибитор глутаминилциклаз и его применение для лечения заболеваний легких и дыхательных путей |
| UA124636C2 (uk) * | 2017-05-26 | 2021-10-20 | Общєство С Огранічєнной Отвєтствєнностью "Фармінтерпрайсез" | Інгібітори глутамінілциклаз і їх застосування для лікування різних захворювань |
| WO2023177328A1 (en) | 2022-03-17 | 2023-09-21 | Treamid Therapeutics Gmbh | Bisamide derivative of dicarboxylic acid for use in restoring the external respiratory function after coronavirus infection |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2665688C2 (ru) * | 2013-04-12 | 2018-09-04 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения |
| RU2647438C2 (ru) * | 2015-05-27 | 2018-03-15 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей |
| UA124636C2 (uk) | 2017-05-26 | 2021-10-20 | Общєство С Огранічєнной Отвєтствєнностью "Фармінтерпрайсез" | Інгібітори глутамінілциклаз і їх застосування для лікування різних захворювань |
-
2015
- 2015-05-27 RU RU2015120055A patent/RU2647438C2/ru active
-
2016
- 2016-05-26 EP EP16800380.4A patent/EP3305286A4/en active Pending
- 2016-05-26 MX MX2017015192A patent/MX2017015192A/es unknown
- 2016-05-26 JP JP2017561321A patent/JP6700312B2/ja active Active
- 2016-05-26 KR KR1020177037304A patent/KR102174191B1/ko active IP Right Grant
- 2016-05-26 CN CN201680044227.3A patent/CN108024978B/zh active Active
- 2016-05-26 UA UAA201712838A patent/UA122336C2/uk unknown
- 2016-05-26 EA EA201792565A patent/EA034437B1/ru active IP Right Revival
- 2016-05-26 SG SG11201709654YA patent/SG11201709654YA/en unknown
- 2016-05-26 WO PCT/RU2016/050015 patent/WO2016190785A1/ru active Application Filing
- 2016-05-26 RU RU2017144851A patent/RU2727142C2/ru active
- 2016-05-26 AU AU2016266439A patent/AU2016266439B2/en active Active
- 2016-05-26 US US15/576,387 patent/US10076511B2/en active Active
- 2016-05-26 CA CA2986911A patent/CA2986911C/en active Active
- 2016-05-26 MA MA045829A patent/MA45829A/fr unknown
- 2016-05-26 BR BR112017025283-0A patent/BR112017025283A2/pt not_active Application Discontinuation
-
2017
- 2017-11-26 IL IL255899A patent/IL255899B/en unknown
-
2018
- 2018-05-25 HK HK18106870.2A patent/HK1247126A1/zh unknown
- 2018-08-14 US US16/103,264 patent/US10772870B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2647438C2 (ru) | 2018-03-15 |
| WO2016190785A1 (ru) | 2016-12-01 |
| HK1247126A1 (zh) | 2018-09-21 |
| SG11201709654YA (en) | 2017-12-28 |
| CN108024978B (zh) | 2020-11-20 |
| US10772870B2 (en) | 2020-09-15 |
| EA201792565A1 (ru) | 2018-04-30 |
| CA2986911A1 (en) | 2016-12-01 |
| US20180353479A1 (en) | 2018-12-13 |
| EP3305286A4 (en) | 2019-06-12 |
| AU2016266439B2 (en) | 2020-05-14 |
| US10076511B2 (en) | 2018-09-18 |
| KR20180035739A (ko) | 2018-04-06 |
| EP3305286A1 (en) | 2018-04-11 |
| UA122336C2 (uk) | 2020-10-26 |
| IL255899B (en) | 2022-04-01 |
| KR102174191B1 (ko) | 2020-11-05 |
| JP6700312B2 (ja) | 2020-05-27 |
| EA034437B1 (ru) | 2020-02-07 |
| RU2727142C2 (ru) | 2020-07-21 |
| AU2016266439A1 (en) | 2018-01-25 |
| RU2017144851A (ru) | 2019-06-27 |
| RU2015120055A (ru) | 2016-12-20 |
| CN108024978A (zh) | 2018-05-11 |
| US20180147184A1 (en) | 2018-05-31 |
| IL255899A (en) | 2018-01-31 |
| MX2017015192A (es) | 2018-08-01 |
| JP2018515584A (ja) | 2018-06-14 |
| RU2017144851A3 (pt) | 2019-07-17 |
| CA2986911C (en) | 2020-06-23 |
| MA45829A (fr) | 2019-06-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: TREAMID GMBH (DE) |
|
| B25F | Entry of change of name and/or headquarter and transfer of application, patent and certif. of addition of invention: change of name on requirement |
Owner name: TREAMID GMBH (DE) Free format text: A FIM DE ATENDER A ALTERACAO DE NOME E DE ENDERECO REQUERIDAS ATRAVES DA PETICAO NO 870190029890, DE 28/03/2019, E NECESSARIO APRESENTAR MAIS UMA GUIA DE RECOLHIMENTO, CODIGO 248, RELATIVA AO SEGUNDO SERVICO SOLICITADO, ALEM DA GUIA DE CUMPRIMENTO DE EXIGENCIA. |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B25D | Requested change of name of applicant approved |
Owner name: TREAMID THERAPEUTICS GMBH (DE) |
|
| B25G | Requested change of headquarter approved |
Owner name: TREAMID THERAPEUTICS GMBH (DE) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B154 | Notification of filing of divisional application [chapter 15.50 patent gazette] |
Free format text: O PEDIDO FOI DIVIDIDO NO BR122024007218-1 PROTOCOLO 870240032035 EM 12/04/2024 17:05. |
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| B09B | Patent application refused [chapter 9.2 patent gazette] |