BR112017017189A2 - mistura de ácidos carboxílicos para o tratamento de pacientes com insuficiência renal - Google Patents
mistura de ácidos carboxílicos para o tratamento de pacientes com insuficiência renalInfo
- Publication number
- BR112017017189A2 BR112017017189A2 BR112017017189-9A BR112017017189A BR112017017189A2 BR 112017017189 A2 BR112017017189 A2 BR 112017017189A2 BR 112017017189 A BR112017017189 A BR 112017017189A BR 112017017189 A2 BR112017017189 A2 BR 112017017189A2
- Authority
- BR
- Brazil
- Prior art keywords
- renal
- patients
- treatment
- acid
- replacement therapy
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000001647 Renal Insufficiency Diseases 0.000 title 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title 1
- 201000006370 kidney failure Diseases 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 238000012959 renal replacement therapy Methods 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 208000020832 chronic kidney disease Diseases 0.000 abstract 2
- 230000003907 kidney function Effects 0.000 abstract 2
- 210000002966 serum Anatomy 0.000 abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- 238000005891 transamination reaction Methods 0.000 abstract 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
- 206010020575 Hyperammonaemia Diseases 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 208000028208 end stage renal disease Diseases 0.000 abstract 1
- 201000000523 end stage renal failure Diseases 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 235000013922 glutamic acid Nutrition 0.000 abstract 1
- 239000004220 glutamic acid Substances 0.000 abstract 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
- 238000001631 haemodialysis Methods 0.000 abstract 1
- 230000000322 hemodialysis Effects 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 229940049920 malate Drugs 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-L oxaloacetate(2-) Chemical compound [O-]C(=O)CC(=O)C([O-])=O KHPXUQMNIQBQEV-UHFFFAOYSA-L 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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Abstract
atualmente, o tratamento para pacientes com enfermidade renal terminal (etapa v) consiste em terapia renal substitutiva (hemodiálises, diálise peritoneal ou transplante renal); extraordinariamente custosa que implica uma pobre qualidade de vida. a invenção é uma mistura de ácidos carboxílicos: ácido cítrico, ácido succínico, ácido fumárico e ácido málico, e quaisquer de suas combinações possíveis. este produto se utiliza preferentemente via oral ou também via intravenosa, no tratamento de pacientes com insuficiência renal crônica, hiperamonemia ou condições humanas que apresentam equilíbrio nitrogenado negativo. este produto é benéfico para diminuir os valores séricos de ureia e de amônio sérico, ao tempo que por transaminação do oxalacetato formado via succinato, fumarato e malato, promove a biossínteses de aminoácidos nos essenciais; por transaminação do alfa ceto glutarato formado via citrato, gera ácido glutâmico e os aminoácidos relacionados ao mesmo como glutamina. este tratamento prevê, preserva e inclusive melhora a função renal. os pacientes retardam o deterioro da função renal e a imperiosa necessidade do tratamento renal substitutivo. em outros mais, se utiliza como tratamento complementário ao tratamento renal substitutivo para melhorar a qualidade de vida do paciente e melhorar os parâmetros laboratoriais.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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MX2015003641A MX357998B (es) | 2015-03-20 | 2015-03-20 | Una mezcla de acidos carboxilicos, especificamente acido citrico, acido succinico, acido fumarico y acido malico para el tratamiento de pacientes con insuficiencia renal cronica, insuficiencia renal aguda, hepatopatias agudas o cronicas que cursen con hiperamonemia, enfermedades congenitas con alteraciones enzimaticas en el ciclo de la urea, asi como condiciones clínicas que cursen con balance nitrogenado negativo. |
MXMX/A/2015/003641 | 2015-03-20 | ||
PCT/MX2015/000144 WO2016153331A1 (es) | 2015-03-20 | 2015-11-04 | Mezcla de ácidos carboxilicos para tratar pacientes con insuficiencia renal |
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BR112017017189A2 true BR112017017189A2 (pt) | 2018-04-03 |
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BR112017017189-9A BR112017017189A2 (pt) | 2015-03-20 | 2015-11-04 | mistura de ácidos carboxílicos para o tratamento de pacientes com insuficiência renal |
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US (2) | US10688068B2 (pt) |
EP (1) | EP3219315B1 (pt) |
JP (1) | JP6771191B2 (pt) |
KR (1) | KR102057555B1 (pt) |
CN (1) | CN108024981B (pt) |
AU (1) | AU2015387986B2 (pt) |
BR (1) | BR112017017189A2 (pt) |
CA (1) | CA2972889C (pt) |
CL (1) | CL2017001262A1 (pt) |
CO (1) | CO2017007046A2 (pt) |
CR (1) | CR20170320A (pt) |
DO (1) | DOP2017000161A (pt) |
EA (1) | EA036702B1 (pt) |
EC (1) | ECSP17056559A (pt) |
ES (1) | ES2850998T3 (pt) |
GT (1) | GT201700149A (pt) |
HK (1) | HK1249426A1 (pt) |
IL (1) | IL253480B (pt) |
MX (1) | MX357998B (pt) |
MY (1) | MY173111A (pt) |
NZ (1) | NZ733186A (pt) |
PE (1) | PE20180228A1 (pt) |
PH (1) | PH12017501157B1 (pt) |
SG (1) | SG11201705163XA (pt) |
TN (1) | TN2017000257A1 (pt) |
WO (1) | WO2016153331A1 (pt) |
Families Citing this family (9)
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WO2018193648A1 (ja) * | 2017-04-18 | 2018-10-25 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
JP7219898B2 (ja) * | 2017-04-18 | 2023-02-09 | 国立大学法人東北大学 | アルカリ性化剤による血液浄化 |
IT201700087359A1 (it) * | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
IT201700087376A1 (it) | 2017-07-28 | 2019-01-28 | Professional Dietetics Spa | Composizioni comprendenti amino acidi per l'uso nel trattamento di malattie associate a disfunzione mitocondriale |
WO2020080499A1 (ja) * | 2018-10-17 | 2020-04-23 | 国立大学法人東北大学 | 新規医薬組成物 |
CN109125310A (zh) * | 2018-11-06 | 2019-01-04 | 河北工业大学 | 琥珀酸在抑制Kv10.1离子通道活性中的应用和药物 |
EP3976559A4 (en) | 2019-05-30 | 2023-06-21 | Koch Agronomic Services, LLC | FOLIAR SOLUTIONS OF MICRONUTRIENTS |
US11666548B2 (en) * | 2020-06-05 | 2023-06-06 | Baxter International Inc. | Parenteral nutrition formulation |
CN115414383A (zh) * | 2022-10-14 | 2022-12-02 | 青岛普瑞森医药科技有限公司 | 血液透析浓缩液及其制备方法 |
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US5475031A (en) * | 1993-09-03 | 1995-12-12 | Livingston; William H. | Discovery of a valuable property for succinic acid and other intermediary metabolites |
US5500232A (en) * | 1994-10-06 | 1996-03-19 | Bristol-Myers Squibb Company | Calcium fortified beverages |
US6488961B1 (en) * | 1996-09-20 | 2002-12-03 | Ethypharm, Inc. | Effervescent granules and methods for their preparation |
EP0938849A1 (en) | 1998-02-18 | 1999-09-01 | Quest International B.V. | A composition with a fresh, fruit like taste |
US6288116B1 (en) * | 1998-05-13 | 2001-09-11 | Novartis Nutrition Ag | Method of administration of a nutritional product to a person having renal failure |
AU7032700A (en) * | 1999-10-12 | 2001-04-23 | Meiji Seika Kaisha Ltd. | Low potassium juice, method for producing thereof and food containing the same |
AU2002211770A1 (en) * | 2000-10-16 | 2002-04-29 | Pepsico, Inc. | Calcium-supplemented beverages and method of making same |
US20030211204A1 (en) * | 2002-05-10 | 2003-11-13 | Fields Christine C. | Method of preparing beverages and beverage concentrates nutritionally supplemented with minerals |
US20090186127A1 (en) * | 2004-12-15 | 2009-07-23 | Krumhar Kim C | Energy drink compositions |
BRPI0602825A2 (pt) * | 2006-06-23 | 2012-04-24 | Rhodia Br Ltda | formulação de pó efervescente auto-refrigerante para bebidas e uso de formulação em pó efervescente |
US20080058421A1 (en) | 2006-09-05 | 2008-03-06 | John Alex Lopes | Compositions for cleaning and disinfecting nasal tract and sinus cavity |
CN101568334A (zh) * | 2006-12-12 | 2009-10-28 | 味之素株式会社 | 铁代谢改善剂 |
JP5592609B2 (ja) * | 2006-12-12 | 2014-09-17 | エイワイファーマ株式会社 | 鉄代謝改善剤 |
US20080226799A1 (en) * | 2007-03-14 | 2008-09-18 | Concentrate Manufacturing Company Of Ireland | Diet Cola Beverages |
BRPI0816066A2 (pt) * | 2007-08-31 | 2017-05-02 | C B Fleet Company Incorporated | método de prevenção de nefrocalcinose |
NZ595867A (en) * | 2009-05-15 | 2015-05-29 | Biocepta Corp | Compositions suitable for the topical treatment of fungal infections of the skin and nails |
NL2009407C2 (en) | 2012-09-03 | 2014-03-04 | Dutch Renewable Energy B V | Antimicrobial composition. |
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2015
- 2015-03-20 MX MX2015003641A patent/MX357998B/es active IP Right Grant
- 2015-11-04 MY MYPI2017702409A patent/MY173111A/en unknown
- 2015-11-04 AU AU2015387986A patent/AU2015387986B2/en not_active Ceased
- 2015-11-04 KR KR1020177022643A patent/KR102057555B1/ko active IP Right Grant
- 2015-11-04 SG SG11201705163XA patent/SG11201705163XA/en unknown
- 2015-11-04 TN TN2017000257A patent/TN2017000257A1/en unknown
- 2015-11-04 WO PCT/MX2015/000144 patent/WO2016153331A1/es active Application Filing
- 2015-11-04 EA EA201700339A patent/EA036702B1/ru unknown
- 2015-11-04 BR BR112017017189-9A patent/BR112017017189A2/pt not_active Application Discontinuation
- 2015-11-04 US US15/547,620 patent/US10688068B2/en active Active
- 2015-11-04 EP EP15886606.1A patent/EP3219315B1/en active Active
- 2015-11-04 JP JP2017541850A patent/JP6771191B2/ja active Active
- 2015-11-04 PE PE2017001076A patent/PE20180228A1/es not_active Application Discontinuation
- 2015-11-04 ES ES15886606T patent/ES2850998T3/es active Active
- 2015-11-04 CA CA2972889A patent/CA2972889C/en active Active
- 2015-11-04 CR CR20170320A patent/CR20170320A/es unknown
- 2015-11-04 NZ NZ733186A patent/NZ733186A/en unknown
- 2015-11-04 CN CN201580072466.5A patent/CN108024981B/zh active Active
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2017
- 2017-05-17 CL CL2017001262A patent/CL2017001262A1/es unknown
- 2017-06-20 PH PH12017501157A patent/PH12017501157B1/en unknown
- 2017-06-27 GT GT201700149A patent/GT201700149A/es unknown
- 2017-07-06 DO DO2017000161A patent/DOP2017000161A/es unknown
- 2017-07-13 IL IL253480A patent/IL253480B/en active IP Right Grant
- 2017-07-13 CO CONC2017/0007046A patent/CO2017007046A2/es unknown
- 2017-08-28 EC ECIEPI201756559A patent/ECSP17056559A/es unknown
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2018
- 2018-07-12 HK HK18109048.3A patent/HK1249426A1/zh unknown
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2019
- 2019-11-29 US US16/699,207 patent/US20200138755A1/en not_active Abandoned
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