BR112017013194A2 - síntese total de trioxacarcina dc-45-a2 e preparação de análogos de trioxacarcina - Google Patents
síntese total de trioxacarcina dc-45-a2 e preparação de análogos de trioxacarcinaInfo
- Publication number
- BR112017013194A2 BR112017013194A2 BR112017013194-3A BR112017013194A BR112017013194A2 BR 112017013194 A2 BR112017013194 A2 BR 112017013194A2 BR 112017013194 A BR112017013194 A BR 112017013194A BR 112017013194 A2 BR112017013194 A2 BR 112017013194A2
- Authority
- BR
- Brazil
- Prior art keywords
- trioxacarcin
- preparation
- analogs
- total synthesis
- methods
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 1
- 238000006257 total synthesis reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094662P | 2014-12-19 | 2014-12-19 | |
| US62/094,662 | 2014-12-19 | ||
| US201562186128P | 2015-06-29 | 2015-06-29 | |
| US62/186,128 | 2015-06-29 | ||
| PCT/US2015/066703 WO2016100833A2 (en) | 2014-12-19 | 2015-12-18 | Total synthesis of trioxacarcin dc-45-a2 and preparation of trioxacarcin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017013194A2 true BR112017013194A2 (pt) | 2018-01-02 |
Family
ID=56127867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017013194-3A BR112017013194A2 (pt) | 2014-12-19 | 2015-12-18 | síntese total de trioxacarcina dc-45-a2 e preparação de análogos de trioxacarcina |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10899773B2 (enExample) |
| EP (1) | EP3233877A4 (enExample) |
| JP (1) | JP2017537968A (enExample) |
| KR (1) | KR20170122718A (enExample) |
| CN (1) | CN107250144A (enExample) |
| AU (1) | AU2015364347A1 (enExample) |
| BR (1) | BR112017013194A2 (enExample) |
| CA (1) | CA2970955A1 (enExample) |
| CL (1) | CL2017001599A1 (enExample) |
| CO (1) | CO2017007074A2 (enExample) |
| CR (1) | CR20170331A (enExample) |
| DO (1) | DOP2017000144A (enExample) |
| EA (1) | EA201791388A1 (enExample) |
| EC (1) | ECSP17046657A (enExample) |
| GT (1) | GT201700139A (enExample) |
| HK (1) | HK1243422A1 (enExample) |
| IL (1) | IL252947A0 (enExample) |
| MA (1) | MA41216A (enExample) |
| MX (1) | MX2017008162A (enExample) |
| PE (1) | PE20171787A1 (enExample) |
| PH (1) | PH12017501147A1 (enExample) |
| SG (1) | SG11201704935XA (enExample) |
| WO (1) | WO2016100833A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019036537A1 (en) * | 2017-08-17 | 2019-02-21 | William Marsh Rice University | ANALOGUES AND DIMER OF TRIOXACARCIN AS POWERFUL ANTICANCER AGENTS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815995A (ja) | 1981-07-22 | 1983-01-29 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−４５−ａ↓１およびｄｃ−４５−ａ↓２ならびにそれらの製造法 |
| EP0157203A3 (en) * | 1984-04-04 | 1986-10-01 | American Cyanamid Company | Antitumor agents ll-d49194 alpha 1, ll-d49194 beta, ll-d49194 beta 2, ll-d49194 upsilon, ll-d49194 delta, ll-d49194 epsilon, ll-d49194 zeta, and ll-d49194 eta |
| JPS63135389A (ja) * | 1986-11-26 | 1988-06-07 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−４５類の誘導体 |
| US9102697B2 (en) * | 2010-03-22 | 2015-08-11 | President And Fellows Of Harvard College | Trioxacarcins and uses thereof |
| EP2922575B1 (en) * | 2012-11-26 | 2019-06-26 | President and Fellows of Harvard College | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof |
-
2015
- 2015-12-17 MA MA041216A patent/MA41216A/fr unknown
- 2015-12-18 US US15/537,319 patent/US10899773B2/en active Active
- 2015-12-18 AU AU2015364347A patent/AU2015364347A1/en not_active Abandoned
- 2015-12-18 KR KR1020177020092A patent/KR20170122718A/ko not_active Withdrawn
- 2015-12-18 SG SG11201704935XA patent/SG11201704935XA/en unknown
- 2015-12-18 HK HK18102899.8A patent/HK1243422A1/zh unknown
- 2015-12-18 EP EP15871176.2A patent/EP3233877A4/en not_active Withdrawn
- 2015-12-18 EA EA201791388A patent/EA201791388A1/ru unknown
- 2015-12-18 WO PCT/US2015/066703 patent/WO2016100833A2/en not_active Ceased
- 2015-12-18 MX MX2017008162A patent/MX2017008162A/es unknown
- 2015-12-18 CA CA2970955A patent/CA2970955A1/en not_active Abandoned
- 2015-12-18 PE PE2017001101A patent/PE20171787A1/es unknown
- 2015-12-18 CN CN201580076346.2A patent/CN107250144A/zh active Pending
- 2015-12-18 CR CR20170331A patent/CR20170331A/es unknown
- 2015-12-18 BR BR112017013194-3A patent/BR112017013194A2/pt not_active Application Discontinuation
- 2015-12-18 JP JP2017532666A patent/JP2017537968A/ja not_active Withdrawn
-
2017
- 2017-06-15 IL IL252947A patent/IL252947A0/en unknown
- 2017-06-19 CL CL2017001599A patent/CL2017001599A1/es unknown
- 2017-06-19 PH PH12017501147A patent/PH12017501147A1/en unknown
- 2017-06-19 GT GT201700139A patent/GT201700139A/es unknown
- 2017-06-19 DO DO2017000144A patent/DOP2017000144A/es unknown
- 2017-07-14 CO CONC2017/0007074A patent/CO2017007074A2/es unknown
- 2017-07-19 EC ECIEPI201746657A patent/ECSP17046657A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016100833A3 (en) | 2017-01-05 |
| EP3233877A2 (en) | 2017-10-25 |
| AU2015364347A1 (en) | 2017-07-13 |
| PE20171787A1 (es) | 2017-12-28 |
| DOP2017000144A (es) | 2017-09-29 |
| MX2017008162A (es) | 2018-03-06 |
| EA201791388A1 (ru) | 2017-11-30 |
| ECSP17046657A (es) | 2019-03-29 |
| MA41216A (fr) | 2017-10-24 |
| SG11201704935XA (en) | 2017-07-28 |
| US20190023717A1 (en) | 2019-01-24 |
| CN107250144A (zh) | 2017-10-13 |
| GT201700139A (es) | 2018-10-24 |
| CL2017001599A1 (es) | 2018-11-09 |
| US10899773B2 (en) | 2021-01-26 |
| JP2017537968A (ja) | 2017-12-21 |
| EP3233877A4 (en) | 2018-10-17 |
| HK1243422A1 (zh) | 2018-07-13 |
| CR20170331A (es) | 2017-11-17 |
| CA2970955A1 (en) | 2016-06-23 |
| KR20170122718A (ko) | 2017-11-06 |
| IL252947A0 (en) | 2017-08-31 |
| PH12017501147A1 (en) | 2018-03-05 |
| WO2016100833A2 (en) | 2016-06-23 |
| CO2017007074A2 (es) | 2017-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |