CN107250144A - 三草癌菌素dc‑45‑a2的全合成及三草癌菌素类似物的制备 - Google Patents
三草癌菌素dc‑45‑a2的全合成及三草癌菌素类似物的制备 Download PDFInfo
- Publication number
- CN107250144A CN107250144A CN201580076346.2A CN201580076346A CN107250144A CN 107250144 A CN107250144 A CN 107250144A CN 201580076346 A CN201580076346 A CN 201580076346A CN 107250144 A CN107250144 A CN 107250144A
- Authority
- CN
- China
- Prior art keywords
- substituted
- alkoxy
- compound
- hydrogen
- hydroxyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 Cc1cc2c(*)c(CCCC3=O)c3c(O)c2c2c1[C@@]1O[C@](C3OCCCO3)([C@]34OC3)O[C@@]1[C@@]4(OCCCS)O2 Chemical compound Cc1cc2c(*)c(CCCC3=O)c3c(O)c2c2c1[C@@]1O[C@](C3OCCCO3)([C@]34OC3)O[C@@]1[C@@]4(OCCCS)O2 0.000 description 6
- NJBJSSOSFSJWGT-UHFFFAOYSA-N CCC1C(C)C[CH+]CC1 Chemical compound CCC1C(C)C[CH+]CC1 NJBJSSOSFSJWGT-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094662P | 2014-12-19 | 2014-12-19 | |
| US62/094,662 | 2014-12-19 | ||
| US201562186128P | 2015-06-29 | 2015-06-29 | |
| US62/186,128 | 2015-06-29 | ||
| PCT/US2015/066703 WO2016100833A2 (en) | 2014-12-19 | 2015-12-18 | Total synthesis of trioxacarcin dc-45-a2 and preparation of trioxacarcin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107250144A true CN107250144A (zh) | 2017-10-13 |
Family
ID=56127867
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580076346.2A Pending CN107250144A (zh) | 2014-12-19 | 2015-12-18 | 三草癌菌素dc‑45‑a2的全合成及三草癌菌素类似物的制备 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US10899773B2 (enExample) |
| EP (1) | EP3233877A4 (enExample) |
| JP (1) | JP2017537968A (enExample) |
| KR (1) | KR20170122718A (enExample) |
| CN (1) | CN107250144A (enExample) |
| AU (1) | AU2015364347A1 (enExample) |
| BR (1) | BR112017013194A2 (enExample) |
| CA (1) | CA2970955A1 (enExample) |
| CL (1) | CL2017001599A1 (enExample) |
| CO (1) | CO2017007074A2 (enExample) |
| CR (1) | CR20170331A (enExample) |
| DO (1) | DOP2017000144A (enExample) |
| EA (1) | EA201791388A1 (enExample) |
| EC (1) | ECSP17046657A (enExample) |
| GT (1) | GT201700139A (enExample) |
| HK (1) | HK1243422A1 (enExample) |
| IL (1) | IL252947A0 (enExample) |
| MA (1) | MA41216A (enExample) |
| MX (1) | MX2017008162A (enExample) |
| PE (1) | PE20171787A1 (enExample) |
| PH (1) | PH12017501147A1 (enExample) |
| SG (1) | SG11201704935XA (enExample) |
| WO (1) | WO2016100833A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019036537A1 (en) * | 2017-08-17 | 2019-02-21 | William Marsh Rice University | ANALOGUES AND DIMER OF TRIOXACARCIN AS POWERFUL ANTICANCER AGENTS |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011119549A1 (en) * | 2010-03-22 | 2011-09-29 | President And Fellows Of Harvard College | Trioxacarcins and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815995A (ja) | 1981-07-22 | 1983-01-29 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−４５−ａ↓１およびｄｃ−４５−ａ↓２ならびにそれらの製造法 |
| EP0157203A3 (en) * | 1984-04-04 | 1986-10-01 | American Cyanamid Company | Antitumor agents ll-d49194 alpha 1, ll-d49194 beta, ll-d49194 beta 2, ll-d49194 upsilon, ll-d49194 delta, ll-d49194 epsilon, ll-d49194 zeta, and ll-d49194 eta |
| JPS63135389A (ja) * | 1986-11-26 | 1988-06-07 | Kyowa Hakko Kogyo Co Ltd | Ｄｃ−４５類の誘導体 |
| US9775915B2 (en) * | 2012-11-26 | 2017-10-03 | President And Fellows Of Harvard College | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof |
-
2015
- 2015-12-17 MA MA041216A patent/MA41216A/fr unknown
- 2015-12-18 CR CR20170331A patent/CR20170331A/es unknown
- 2015-12-18 AU AU2015364347A patent/AU2015364347A1/en not_active Abandoned
- 2015-12-18 MX MX2017008162A patent/MX2017008162A/es unknown
- 2015-12-18 CA CA2970955A patent/CA2970955A1/en not_active Abandoned
- 2015-12-18 US US15/537,319 patent/US10899773B2/en active Active
- 2015-12-18 CN CN201580076346.2A patent/CN107250144A/zh active Pending
- 2015-12-18 PE PE2017001101A patent/PE20171787A1/es unknown
- 2015-12-18 EA EA201791388A patent/EA201791388A1/ru unknown
- 2015-12-18 BR BR112017013194-3A patent/BR112017013194A2/pt not_active Application Discontinuation
- 2015-12-18 HK HK18102899.8A patent/HK1243422A1/zh unknown
- 2015-12-18 EP EP15871176.2A patent/EP3233877A4/en not_active Withdrawn
- 2015-12-18 WO PCT/US2015/066703 patent/WO2016100833A2/en not_active Ceased
- 2015-12-18 JP JP2017532666A patent/JP2017537968A/ja not_active Withdrawn
- 2015-12-18 KR KR1020177020092A patent/KR20170122718A/ko not_active Withdrawn
- 2015-12-18 SG SG11201704935XA patent/SG11201704935XA/en unknown
-
2017
- 2017-06-15 IL IL252947A patent/IL252947A0/en unknown
- 2017-06-19 DO DO2017000144A patent/DOP2017000144A/es unknown
- 2017-06-19 GT GT201700139A patent/GT201700139A/es unknown
- 2017-06-19 PH PH12017501147A patent/PH12017501147A1/en unknown
- 2017-06-19 CL CL2017001599A patent/CL2017001599A1/es unknown
- 2017-07-14 CO CONC2017/0007074A patent/CO2017007074A2/es unknown
- 2017-07-19 EC ECIEPI201746657A patent/ECSP17046657A/es unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011119549A1 (en) * | 2010-03-22 | 2011-09-29 | President And Fellows Of Harvard College | Trioxacarcins and uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| JAKUB SVENDA, ET AL.,: "A multiply convergent platform for the synthesis of trioxacarcins.", 《PNAS》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20171787A1 (es) | 2017-12-28 |
| EA201791388A1 (ru) | 2017-11-30 |
| EP3233877A2 (en) | 2017-10-25 |
| IL252947A0 (en) | 2017-08-31 |
| MA41216A (fr) | 2017-10-24 |
| CA2970955A1 (en) | 2016-06-23 |
| WO2016100833A3 (en) | 2017-01-05 |
| BR112017013194A2 (pt) | 2018-01-02 |
| US10899773B2 (en) | 2021-01-26 |
| SG11201704935XA (en) | 2017-07-28 |
| GT201700139A (es) | 2018-10-24 |
| WO2016100833A2 (en) | 2016-06-23 |
| CO2017007074A2 (es) | 2017-10-20 |
| PH12017501147A1 (en) | 2018-03-05 |
| EP3233877A4 (en) | 2018-10-17 |
| JP2017537968A (ja) | 2017-12-21 |
| ECSP17046657A (es) | 2019-03-29 |
| MX2017008162A (es) | 2018-03-06 |
| KR20170122718A (ko) | 2017-11-06 |
| CL2017001599A1 (es) | 2018-11-09 |
| HK1243422A1 (zh) | 2018-07-13 |
| US20190023717A1 (en) | 2019-01-24 |
| DOP2017000144A (es) | 2017-09-29 |
| AU2015364347A1 (en) | 2017-07-13 |
| CR20170331A (es) | 2017-11-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20171013 |