BR112017009633A2 - métodos de tratamento de um paciente com um câncer, para identificar um paciente, para predizer a capacidade de resposta de um paciente, antagonista de vegf para utilização em um método de tratamento de um paciente com um câncer e agente terapêutico - Google Patents

métodos de tratamento de um paciente com um câncer, para identificar um paciente, para predizer a capacidade de resposta de um paciente, antagonista de vegf para utilização em um método de tratamento de um paciente com um câncer e agente terapêutico

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Publication number
BR112017009633A2
BR112017009633A2 BR112017009633A BR112017009633A BR112017009633A2 BR 112017009633 A2 BR112017009633 A2 BR 112017009633A2 BR 112017009633 A BR112017009633 A BR 112017009633A BR 112017009633 A BR112017009633 A BR 112017009633A BR 112017009633 A2 BR112017009633 A2 BR 112017009633A2
Authority
BR
Brazil
Prior art keywords
patient
cancer
treating
vegf antagonist
responsiveness
Prior art date
Application number
BR112017009633A
Other languages
English (en)
Portuguese (pt)
Inventor
Bais Carlos
C Consalvo Nicola
Choi Younjeong
Xiao Yuanyuan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR112017009633A2 publication Critical patent/BR112017009633A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Zoology (AREA)
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  • Biophysics (AREA)
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  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
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BR112017009633A 2014-11-14 2015-11-09 métodos de tratamento de um paciente com um câncer, para identificar um paciente, para predizer a capacidade de resposta de um paciente, antagonista de vegf para utilização em um método de tratamento de um paciente com um câncer e agente terapêutico BR112017009633A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462079787P 2014-11-14 2014-11-14
PCT/US2015/059733 WO2016077227A2 (en) 2014-11-14 2015-11-09 Predicting response to a vegf antagonist

Publications (1)

Publication Number Publication Date
BR112017009633A2 true BR112017009633A2 (pt) 2017-12-19

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BR112017009633A BR112017009633A2 (pt) 2014-11-14 2015-11-09 métodos de tratamento de um paciente com um câncer, para identificar um paciente, para predizer a capacidade de resposta de um paciente, antagonista de vegf para utilização em um método de tratamento de um paciente com um câncer e agente terapêutico

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US (1) US20170226198A1 (enExample)
EP (1) EP3218401B1 (enExample)
JP (1) JP2017535548A (enExample)
KR (1) KR20170082537A (enExample)
CN (1) CN107106688A (enExample)
AR (1) AR102647A1 (enExample)
AU (1) AU2015346652A1 (enExample)
BR (1) BR112017009633A2 (enExample)
CA (1) CA2966216A1 (enExample)
HK (1) HK1242996A1 (enExample)
IL (1) IL251947A0 (enExample)
MX (1) MX2017006201A (enExample)
RU (1) RU2017120388A (enExample)
SG (1) SG11201703744VA (enExample)
WO (1) WO2016077227A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108753984B (zh) * 2018-08-28 2021-07-13 北京市神经外科研究所 预测或诊断脑恶性胶质瘤术后复发的生物标志物组合及其应用和试剂盒
WO2021156137A1 (en) * 2020-02-04 2021-08-12 Oslo Universitetssykehus Hf Biomarkers predicting clinical response of a vegf-a inhibitory drug in cancer patients, method for their selection and use
CA3175129A1 (en) * 2020-03-12 2021-09-19 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
WO2024028846A1 (en) * 2022-08-05 2024-02-08 Geistlich Pharma Ag Combination therapy for treating cancers

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4619651B2 (ja) * 2001-06-01 2011-01-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 前立腺特異的膜抗原に対する修飾抗体およびその使用
US20040191218A1 (en) * 2001-09-26 2004-09-30 Emlen James W Pharmaceutical compositions and methods for treating cancer
CA2517074A1 (en) * 2003-02-27 2004-09-10 Yeda Research And Development Co., Ltd. Nucleic acid molecules, polypeptides, antibodies and compositions containing same useful for treating and detecting influenza virus infection
EP2583685A1 (en) * 2004-06-10 2013-04-24 Regeneron Pharmaceuticals, Inc. Method of administering and using VEGF inhibitors for the treatment of human cancer
JP2012501188A (ja) * 2008-08-29 2012-01-19 ジェネンテック， インコーポレイテッド Ｖｅｇｆ非依存性腫瘍についての診断薬および治療
CN102711830A (zh) * 2010-01-19 2012-10-03 霍夫曼-拉罗奇有限公司 用于贝伐单抗联合疗法的基于肿瘤组织的生物标志
AU2011221229B2 (en) * 2010-02-23 2015-06-18 F. Hoffmann-La Roche Ag Anti-angiogenesis therapy for the treatment of ovarian cancer
CN103140761B (zh) * 2010-07-19 2015-11-25 霍夫曼-拉罗奇有限公司 贝伐单抗组合疗法用于治疗胰腺癌的血浆生物标志物
SG10201505593VA (en) * 2010-07-19 2015-09-29 Hoffmann La Roche Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
EP2596363B1 (en) * 2010-07-19 2017-01-18 F. Hoffmann-La Roche AG Blood plasma biomarkers for bevacizumab combination therapies for treatment of breast cancer
CN103339508A (zh) * 2010-12-09 2013-10-02 霍夫曼-拉罗奇有限公司 Agtr1作为贝伐单抗联合疗法的标志物
WO2012118969A2 (en) * 2011-03-01 2012-09-07 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Method of selecting cancer patients for anti-angiogenesis therapy in combination with chemotherapy
AR089067A1 (es) * 2011-12-05 2014-07-30 Hoffmann La Roche Biomarcadores en el plasma sanguineo para terapias de combinacion de bevacizumab destinadas al tratamiento del cancer de mama

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