BR112017005248A2 - estimuladores de sgc - Google Patents
estimuladores de sgcInfo
- Publication number
- BR112017005248A2 BR112017005248A2 BR112017005248A BR112017005248A BR112017005248A2 BR 112017005248 A2 BR112017005248 A2 BR 112017005248A2 BR 112017005248 A BR112017005248 A BR 112017005248A BR 112017005248 A BR112017005248 A BR 112017005248A BR 112017005248 A2 BR112017005248 A2 BR 112017005248A2
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- sgc stimulators
- formula
- sgc
- stimulators
- Prior art date
Links
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051620P | 2014-09-17 | 2014-09-17 | |
| US201562204672P | 2015-08-13 | 2015-08-13 | |
| PCT/US2015/050458 WO2016044441A1 (en) | 2014-09-17 | 2015-09-16 | Sgc stimulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017005248A2 true BR112017005248A2 (pt) | 2017-12-12 |
Family
ID=54293334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017005248A BR112017005248A2 (pt) | 2014-09-17 | 2015-09-16 | estimuladores de sgc |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10047095B2 (https=) |
| EP (1) | EP3194395B1 (https=) |
| JP (1) | JP2017527605A (https=) |
| KR (1) | KR20170055531A (https=) |
| CN (1) | CN107223125B (https=) |
| AU (1) | AU2015317818A1 (https=) |
| BR (1) | BR112017005248A2 (https=) |
| CA (1) | CA2961531A1 (https=) |
| EA (1) | EA201790627A1 (https=) |
| IL (1) | IL251115A0 (https=) |
| MX (1) | MX2017003517A (https=) |
| WO (1) | WO2016044441A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3194386A2 (en) * | 2014-09-17 | 2017-07-26 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| AU2016371762A1 (en) | 2015-12-14 | 2018-06-21 | Cyclerion Therapeutics, Inc. | Use of sGC stimulators for the treatment of gastrointestinal sphincter dysfunction |
| CN109563077B (zh) | 2016-07-07 | 2026-03-10 | 赛克里翁治疗有限公司 | 用于制备可溶性鸟苷酸环化酶刺激剂的新方法 |
| CA3039735A1 (en) | 2016-10-11 | 2018-04-19 | Bayer Pharma Aktiengesellschaft | Combination containing sgc activators and mineralocorticoid receptor antagonists |
| US10918639B2 (en) | 2016-10-11 | 2021-02-16 | Bayer Pharma Aktiengesellschaft | Combination containing SGC stimulators and mineralocorticoid receptor antagonists |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| WO2018111795A2 (en) | 2016-12-13 | 2018-06-21 | Ironwood Pharmaceuticals, Inc. | Use of sgc stimulators for the treatment of esophageal motility disorders |
| JP7204758B2 (ja) * | 2017-11-08 | 2023-01-16 | オムニペプ・エスタブリッシュメント | 糖尿病性足の場合における組織酸素化を増強するための医療用製剤とその使用 |
| MA71753A (fr) * | 2018-01-10 | 2025-05-30 | Cyclerion Therapeutics, Inc. | Nouveaux procédés et intermédiaires pour la préparation de stimulateurs de guanylate cyclase soluble |
| CA3100096A1 (en) | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| KR20210031931A (ko) | 2018-07-11 | 2021-03-23 | 사이클리온 테라퓨틱스, 인크. | 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도 |
| US12478624B2 (en) | 2019-10-02 | 2025-11-25 | Tolremo Therapeutics Ag | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer |
| IL299344A (en) | 2020-06-25 | 2023-02-01 | Tolremo Therapeutics Ag | Combination of a cbp/p300 bromodomain inhibitor and a kras inhibitor for the treatment of cancer |
| CA3184062A1 (en) * | 2020-06-25 | 2021-12-30 | Stefanie Fluckiger-Mangual | Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment, amelioration or prevention of fibrotic disease |
| BR112023020538A2 (pt) | 2021-04-07 | 2024-01-23 | Tolremo Therapeutics Ag | Derivados heterocíclicos, composições farmacêuticas e seus usos no tratamento ou na melhoria de câncer |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4544999B2 (ja) * | 2002-11-25 | 2010-09-15 | 持田製薬株式会社 | ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤 |
| CN101679371A (zh) * | 2006-12-04 | 2010-03-24 | 艾美罗股份公司 | 作为腺苷受体拮抗剂的取代的嘧啶 |
| AR088020A1 (es) * | 2010-06-30 | 2014-05-07 | Ironwood Pharmaceuticals Inc | Compuestos heterociclicos como estimuladores de sgc |
| EP2637659B1 (en) * | 2010-11-09 | 2016-05-18 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| US9487508B2 (en) * | 2012-09-19 | 2016-11-08 | Ironwood Pharmaceuticals, Inc. | SGC stimulators |
| SI2970243T1 (sl) * | 2013-03-15 | 2020-04-30 | Cyclerion Therapeutics, Inc. | SGC stimulatorji |
| WO2015106268A1 (en) * | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
-
2015
- 2015-09-16 KR KR1020177010076A patent/KR20170055531A/ko not_active Withdrawn
- 2015-09-16 EA EA201790627A patent/EA201790627A1/ru unknown
- 2015-09-16 JP JP2017515198A patent/JP2017527605A/ja active Pending
- 2015-09-16 WO PCT/US2015/050458 patent/WO2016044441A1/en not_active Ceased
- 2015-09-16 CA CA2961531A patent/CA2961531A1/en not_active Abandoned
- 2015-09-16 BR BR112017005248A patent/BR112017005248A2/pt not_active IP Right Cessation
- 2015-09-16 MX MX2017003517A patent/MX2017003517A/es unknown
- 2015-09-16 AU AU2015317818A patent/AU2015317818A1/en not_active Abandoned
- 2015-09-16 EP EP15779068.4A patent/EP3194395B1/en active Active
- 2015-09-16 CN CN201580062215.9A patent/CN107223125B/zh not_active Expired - Fee Related
- 2015-09-16 US US15/511,897 patent/US10047095B2/en active Active
-
2017
- 2017-03-13 IL IL251115A patent/IL251115A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016044441A1 (en) | 2016-03-24 |
| US10047095B2 (en) | 2018-08-14 |
| EP3194395B1 (en) | 2019-12-04 |
| JP2017527605A (ja) | 2017-09-21 |
| IL251115A0 (en) | 2017-04-30 |
| EP3194395A1 (en) | 2017-07-26 |
| KR20170055531A (ko) | 2017-05-19 |
| EA201790627A1 (ru) | 2017-09-29 |
| US20170291902A1 (en) | 2017-10-12 |
| CN107223125B (zh) | 2019-09-27 |
| CN107223125A (zh) | 2017-09-29 |
| MX2017003517A (es) | 2017-07-28 |
| CA2961531A1 (en) | 2016-03-24 |
| AU2015317818A1 (en) | 2017-03-23 |
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