BR112017005167A2 - síntese de ent-progesterona e intermediários da mesma - Google Patents

síntese de ent-progesterona e intermediários da mesma

Info

Publication number
BR112017005167A2
BR112017005167A2 BR112017005167A BR112017005167A BR112017005167A2 BR 112017005167 A2 BR112017005167 A2 BR 112017005167A2 BR 112017005167 A BR112017005167 A BR 112017005167A BR 112017005167 A BR112017005167 A BR 112017005167A BR 112017005167 A2 BR112017005167 A2 BR 112017005167A2
Authority
BR
Brazil
Prior art keywords
progesterone
ent
intermediates
synthesis
relates
Prior art date
Application number
BR112017005167A
Other languages
English (en)
Inventor
E Levy Daniel
W Cran John
Original Assignee
Prevacus Inc
Univ Florida State Res Found Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prevacus Inc, Univ Florida State Res Found Inc filed Critical Prevacus Inc
Publication of BR112017005167A2 publication Critical patent/BR112017005167A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/0805—Compounds with Si-C or Si-Si linkages comprising only Si, C or H atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/50—Organo-phosphines
    • C07F9/5022—Aromatic phosphines (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J15/00—Stereochemically pure steroids containing carbon, hydrogen, halogen or oxygen having a partially or totally inverted skeleton, e.g. retrosteroids, L-isomers
    • C07J15/005—Retrosteroids (9 beta 10 alfa)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

a presente invenção se refere à síntese de ent-progesterona e a intermediários da mesma.
BR112017005167A 2014-09-17 2015-09-17 síntese de ent-progesterona e intermediários da mesma BR112017005167A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462051900P 2014-09-17 2014-09-17
PCT/US2015/050631 WO2016044558A1 (en) 2014-09-17 2015-09-17 Synthesis of ent-progesterone and intermediates thereof

Publications (1)

Publication Number Publication Date
BR112017005167A2 true BR112017005167A2 (pt) 2018-06-19

Family

ID=55533837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017005167A BR112017005167A2 (pt) 2014-09-17 2015-09-17 síntese de ent-progesterona e intermediários da mesma

Country Status (20)

Country Link
US (1) US20160108081A1 (pt)
EP (1) EP3194418B1 (pt)
JP (1) JP2017535596A (pt)
CN (1) CN108064228A (pt)
AR (1) AR101951A1 (pt)
AU (1) AU2015317651A1 (pt)
BR (1) BR112017005167A2 (pt)
CA (1) CA2961628A1 (pt)
CL (1) CL2017000645A1 (pt)
EA (1) EA201790428A1 (pt)
ES (1) ES2910225T3 (pt)
IL (1) IL251237A0 (pt)
MA (1) MA39411A (pt)
PH (1) PH12017500499A1 (pt)
SG (1) SG11201702115SA (pt)
TN (1) TN2017000088A1 (pt)
TW (1) TW201619183A (pt)
UY (1) UY36306A (pt)
WO (1) WO2016044558A1 (pt)
ZA (1) ZA201701976B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015012902A (es) * 2013-03-15 2016-07-20 Univ Florida State Res Found Sintesis de ent-progesterona e intermediarios de la misma.
IT201700004904A1 (it) * 2017-01-18 2018-07-18 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI 9β,10α-PROGESTERONE (RETROPROGESTERONE)
GB202203328D0 (en) 2022-03-10 2022-04-27 Givaudan Sa Organic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2623071A (en) * 1948-05-13 1952-12-23 Synor Res Lab Inc Preparation of substituted cyclopentenones
JPS4926214A (pt) * 1971-07-14 1974-03-08
US4189431A (en) * 1975-08-04 1980-02-19 The Board of Trustees of Leland Stanford Junior University Alkinyl terminating groups in biogenetic-like cyclizations to steroids
JP2001247562A (ja) * 2000-03-07 2001-09-11 Daicel Chem Ind Ltd アミド化合物及びその製造方法
CA2955684A1 (en) * 2008-02-26 2009-09-03 Emory University Steroid analogues for neuroprotection
WO2010088409A2 (en) * 2009-01-30 2010-08-05 Emory University Methods of neuroprotection using neuroprotective steroids and a vitamin d
HUE029002T2 (en) * 2010-12-17 2017-01-30 Mitsubishi Tanabe Pharma Corp Continuous aricyclic compounds
MX2015012902A (es) * 2013-03-15 2016-07-20 Univ Florida State Res Found Sintesis de ent-progesterona e intermediarios de la misma.

Also Published As

Publication number Publication date
TN2017000088A1 (en) 2018-07-04
SG11201702115SA (en) 2017-04-27
PH12017500499A1 (en) 2017-08-30
US20160108081A1 (en) 2016-04-21
EP3194418A4 (en) 2018-12-12
CA2961628A1 (en) 2016-03-24
MA39411A (fr) 2016-03-24
EA201790428A1 (ru) 2017-08-31
UY36306A (es) 2016-04-29
CL2017000645A1 (es) 2018-09-14
EP3194418B1 (en) 2021-12-15
ZA201701976B (en) 2019-06-26
TW201619183A (zh) 2016-06-01
AU2015317651A1 (en) 2017-04-06
CN108064228A (zh) 2018-05-22
IL251237A0 (en) 2017-05-29
JP2017535596A (ja) 2017-11-30
ES2910225T3 (es) 2022-05-12
WO2016044558A1 (en) 2016-03-24
EP3194418A1 (en) 2017-07-26
AR101951A1 (es) 2017-01-25

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]