BR112017004469A2 - material sorvente para separar bio-macromoléculas - Google Patents

material sorvente para separar bio-macromoléculas

Info

Publication number
BR112017004469A2
BR112017004469A2 BR112017004469A BR112017004469A BR112017004469A2 BR 112017004469 A2 BR112017004469 A2 BR 112017004469A2 BR 112017004469 A BR112017004469 A BR 112017004469A BR 112017004469 A BR112017004469 A BR 112017004469A BR 112017004469 A2 BR112017004469 A2 BR 112017004469A2
Authority
BR
Brazil
Prior art keywords
sorbent material
poly
macromolecules
separate bio
heteroaryl
Prior art date
Application number
BR112017004469A
Other languages
English (en)
Inventor
howell Chris
Crozier Emily
Tyson John
James O'halloran Jonathan
H Hedley Joseph
Flanagan Marc
Dixon Rachael
Bhatt Sam
whitehouse Sam
Original Assignee
Quantumdx Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantumdx Group Ltd filed Critical Quantumdx Group Ltd
Publication of BR112017004469A2 publication Critical patent/BR112017004469A2/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/261—Synthetic macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28004—Sorbent size or size distribution, e.g. particle size
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28023—Fibres or filaments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28026—Particles within, immobilised, dispersed, entrapped in or on a matrix, e.g. a resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28042—Shaped bodies; Monolithic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28059—Surface area, e.g. B.E.T specific surface area being less than 100 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28057—Surface area, e.g. B.E.T specific surface area
    • B01J20/28061—Surface area, e.g. B.E.T specific surface area being in the range 100-500 m2/g
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/2808—Pore diameter being less than 2 nm, i.e. micropores or nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28083—Pore diameter being in the range 2-50 nm, i.e. mesopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/327—Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3276—Copolymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

resumo ?material sorvente para separar bio-macromoléculas? um material sorvente é divulgado para a separação de etapa única de bio-macromoléculas em uma extração de passagem única de dna a partir de misturas complexas de moléculas e produtos químicos. em uma forma de realização, o material sorvente compreende um material silanizado pelo menos parcialmente revestido ou formado com um polímero selecionado do grupo consistindo em um poli(metacrilato de arila), um poli(acrilato de arila), um poli(metacrilato de heteroarila, um poli(acrilato de heteroarila) e um copolímero deste.
BR112017004469A 2014-09-10 2015-09-10 material sorvente para separar bio-macromoléculas BR112017004469A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462048754P 2014-09-10 2014-09-10
US201562099872P 2015-01-05 2015-01-05
US201562157326P 2015-05-05 2015-05-05
PCT/US2015/049519 WO2016040697A1 (en) 2014-09-10 2015-09-10 Sorbent material for separating bio-macromolecules

Publications (1)

Publication Number Publication Date
BR112017004469A2 true BR112017004469A2 (pt) 2017-12-05

Family

ID=55459586

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017004469A BR112017004469A2 (pt) 2014-09-10 2015-09-10 material sorvente para separar bio-macromoléculas

Country Status (11)

Country Link
US (1) US10792640B2 (pt)
EP (1) EP3191590B1 (pt)
JP (1) JP6698076B2 (pt)
KR (1) KR102275804B1 (pt)
CN (1) CN106604992B (pt)
AU (1) AU2015314928B2 (pt)
BR (1) BR112017004469A2 (pt)
CA (1) CA2960428C (pt)
SG (1) SG11201701783QA (pt)
WO (1) WO2016040697A1 (pt)
ZA (1) ZA201701786B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201703625D0 (en) 2017-03-07 2017-04-19 Quantumdx Group Ltd Aptamer based methods for protein detection
CN108795727A (zh) * 2018-07-06 2018-11-13 大连元和健路医学检验实验室有限公司 一种快速提取基因组dna的分子筛柱子
CN108795929A (zh) * 2018-07-06 2018-11-13 大连元和健路医学检验实验室有限公司 一种dna分子筛柱子的制备方法
EP4354134A2 (en) * 2018-10-02 2024-04-17 Waters Technologies Corporation Sorbents, devices, kits and methods useful for biological sample treatment
EP3871748A4 (en) * 2018-10-23 2022-08-03 Teijin Limited FILTER FOR FILTERING, CONTAINER WITH THE FILTER AND METHOD FOR REMOVING FOREIGN SUBSTANCES IN A CELL SUSPENSION
GB201819417D0 (en) * 2018-11-29 2019-01-16 Quantumdx Group Ltd Vacuum-assisted drying of filters in microfluidic systems
CN112898469B (zh) * 2021-01-25 2023-04-18 三明学院 一种具有微孔结构的全芳基簇发光聚合物及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB467900A (en) 1935-12-20 1937-06-21 Du Pont Esters of methacrylic acid and their manufacture
US3987058A (en) * 1975-02-27 1976-10-19 The United States Of America As Represented By The Secretary Of Agriculture Preparation and uses of stable, bound stationary phases
US5047438A (en) * 1988-09-26 1991-09-10 Supelco, Inc. Porous rigid resins and process of preparation
JP2540667B2 (ja) 1989-07-06 1996-10-09 パーセプティブ バイオシステムズ，インコーポレイテッド パ―ヒュ―シブクロマトグラフィ―
DE4233396A1 (de) * 1992-10-05 1994-04-07 Merck Patent Gmbh Oberflächenmodifizierte Oxidpartikel und ihre Anwendung als Füll- und Modifizierungsmittel in Polymermaterialien
US5470463A (en) * 1992-06-19 1995-11-28 Sepracor Inc. Passivated porous supports and methods for the preparation and use of same
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US7078224B1 (en) * 1999-05-14 2006-07-18 Promega Corporation Cell concentration and lysate clearance using paramagnetic particles
KR100547959B1 (ko) * 1998-07-30 2006-02-02 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 투명한 금속 산화물 콜로이드 및 세라머를 제조하기 위한 나노크기 금속 산화물 입자
DE19962577A1 (de) * 1999-12-23 2001-07-12 Tittgen Biotechnologie Dr Chromatographiematerial und Verfahren unter Verwendung desselben
US7169298B2 (en) 2000-01-26 2007-01-30 Transgenomic, Inc. Method and apparatus for separating polynucleotides using monolithic capillary columns
US6623733B1 (en) 2001-06-27 2003-09-23 Advanced Cardiovascular Systems, Inc. Methods for treatment of vascular disease and device for preparation of an autologous composition for treating vascular disease
US20040127648A1 (en) 2002-12-31 2004-07-01 Ciphergen Biosystems, Inc. Sorbent and method for the separation of plasmid DNA
FR2854071B1 (fr) 2003-04-25 2009-01-30 Ethypharm Sa Procede de dispersion de substances hydrosolubles ou hydrophiles dans un fluide a pression supercritique
WO2005095476A1 (en) * 2004-04-02 2005-10-13 Nexttec Gmbh Process for manufacturing a composite sorbent material for chromatographical separation of biopolymers
US20060057738A1 (en) * 2004-09-16 2006-03-16 Hall Gerald E Jr Device, method, system and kit, for collecting components from a biological sample
JP2009500019A (ja) * 2005-07-01 2009-01-08 プロメガ・コーポレーション 生体分子の精製のための浮遊性粒子のネットワーク、及び生体分子の精製のための浮遊性粒子又は浮遊性粒子のネットワークの使用
EP2610056B1 (en) * 2006-06-12 2016-09-21 Solvay USA Inc. Hydrophilized substrate and method for hydrophilizing a hydrophobic surface of a substrate
US20080116137A1 (en) * 2006-11-22 2008-05-22 Leopold-Franzens-Universitat Innsbruck Monolithic organic copolymer
US8377379B2 (en) 2006-12-15 2013-02-19 Kimberly-Clark Worldwide, Inc. Lateral flow assay device
RU2010132429A (ru) * 2008-01-04 2012-02-10 Спарксис Б.В. (Nl) Модификация поверхности металлоксидных наночастиц
DE102008063001A1 (de) 2008-12-23 2010-06-24 Qiagen Gmbh Nukleinsäureaufreinigungsverfahren
EP2396405B1 (en) * 2009-02-11 2016-12-14 University Of Rochester Spatially inhomogenously functionalized porous media and method for use in selective removal of contaminants
CA2754594C (en) * 2009-03-13 2018-05-15 Akzo Nobel Chemicals International B.V. Aqueous silanized silica dispersion
US8303911B2 (en) * 2009-10-19 2012-11-06 The Regents Of The University Of California Centrifugal microfluidic system for nucleic acid sample preparation, amplification, and detection
BR112013013325A2 (pt) * 2010-11-30 2020-08-11 Quantumdx Group Limited dispositivo e método para simultaneamente extrair e fracionar dna de lisado ou amostra integral e para fabricar dispositivo microfluídico
MX353414B (es) * 2011-03-25 2018-01-11 Akzo Nobel Chemicals Int Bv Composicion de recubrimiento base alquido.
AU2012313982A1 (en) * 2011-09-28 2014-05-15 King Abdullah University Of Science And Technology Grafted membranes and substrates having surfaces with switchable superoleophilicity and superoleophobicity and applications thereof
US9938390B2 (en) 2012-11-26 2018-04-10 Eth Zurich Method for the preparation of macroporous particles and macroporous microclusters

Also Published As

Publication number Publication date
NZ729970A (en) 2021-10-29
JP2017529999A (ja) 2017-10-12
CA2960428A1 (en) 2016-03-17
AU2015314928B2 (en) 2020-07-02
SG11201701783QA (en) 2017-04-27
CA2960428C (en) 2021-10-19
EP3191590A4 (en) 2018-08-01
WO2016040697A1 (en) 2016-03-17
JP6698076B2 (ja) 2020-05-27
US10792640B2 (en) 2020-10-06
CN106604992A (zh) 2017-04-26
AU2015314928A1 (en) 2017-03-30
ZA201701786B (en) 2022-05-25
CN106604992B (zh) 2021-06-18
EP3191590B1 (en) 2024-02-21
KR20170053635A (ko) 2017-05-16
KR102275804B1 (ko) 2021-07-08
US20170282154A1 (en) 2017-10-05
EP3191590A1 (en) 2017-07-19

Similar Documents

Publication Publication Date Title
BR112017004469A2 (pt) material sorvente para separar bio-macromoléculas
CY1122510T1 (el) Μορια αντισωματος σε lag-3 και χρησεις αυτων
CO2018000046A2 (es) Anticuerpos anti–tau
MA41507A (fr) Systèmes et procédés de production de polymères
MA40069A (fr) Molécules de liaison trispécifiques et leurs procédés d'utilisation
EP3191530A4 (en) Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
EP3368178A4 (en) METHODS AND SYSTEMS FOR REGULATING DNA, RNA AND OTHER BIOLOGICAL MOLECULES CROSSING NANOPORES
EP4235174A3 (en) Field effect transistor, device including the transistor, and methods of forming and using same
AR102453A1 (es) Aditivo de nanocristales de celulosa o nanofibrillas de celulosa modificadas de forma química
EP3387132A4 (en) APTAMERS, NUCLEIC ACID MOLECULES, POLYNUCLEOTIDES, SYNTHETIC ANTIBODY COMPOSITIONS FOR THE DETECTION OF PRRS VIRUSES AND TREATMENT OF PRRS VIRUS INFECTION
EP3229288A4 (en) Polymer, mixture and compound containing same, and organic electronic device and monomer thereof
BR112019007309A2 (pt) anticorpos anti-c1s e métodos de uso dos mesmos
FR3043680B1 (fr) Composition de caoutchouc comprenant un polymere dienique fonctionnel
FR3024732B1 (fr) Polymere hydroxyalkyle hydrosoluble obtenu par procede de polymerisation en suspension inverse ou emulsion inverse
BR112017007648A2 (pt) emulsões de acetato de etileno vinila/polímero acrílico e produtos e métodos relacionados às mesmas
FR3045614B1 (fr) Polymere sequence a groupements acide phosphonique et ses applications en cosmetique
Olsen Engineering materials from proteins.
FR3012455B1 (fr) Polymere de diene fonctionnel, son procede de preparation, et composition de caoutchouc le comprenant
EA201500924A1 (ru) Способ определения модифицирующей активности
BR112019000630A2 (pt) regimes de dosagem dos antagonistas de lingo-1 e usos para tratamento de distúrbios desmielinizante
MX2016015279A (es) Copolimeros utiles como clarificadores del agua y para la separacion de agua y aceite.
FR3044314B1 (fr) Composition de caoutchouc a base de caoutchouc naturel ayant une distribution de masse moleculaire, vue en sec-mals, bimodale, procede de preparation et composant de pneumatique
PL409981A1 (pl) Nowy przewodzący polimer bisbitiofenowy, wdrukowany molekularnie za pomocą neopteryny, i sposób jego przygotowania oraz zastosowanie tego polimeru jako warstwy rozpoznającej czujnika chemicznego do selektywnego wykrywania i/lub oznaczania neopteryny
FR3027905B1 (fr) Procede de polymerisation de l'acide (meth)acrylique en solution.
AR113069A1 (es) VARIANTES DE ANTICUERPOS QUE SE UNEN A TNFa

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time