BR112016030183A2 - anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos - Google Patents
anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulosInfo
- Publication number
- BR112016030183A2 BR112016030183A2 BR112016030183A BR112016030183A BR112016030183A2 BR 112016030183 A2 BR112016030183 A2 BR 112016030183A2 BR 112016030183 A BR112016030183 A BR 112016030183A BR 112016030183 A BR112016030183 A BR 112016030183A BR 112016030183 A2 BR112016030183 A2 BR 112016030183A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibodies
- microtubule
- antigen binding
- specifically bind
- binding fragments
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 title abstract 2
- 102000013498 tau Proteins Human genes 0.000 title abstract 2
- 108010026424 tau Proteins Proteins 0.000 title abstract 2
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Abstract
a invenção se refere a anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos. a invenção também se refere a métodos de diagnóstico, profiláticos e terapêuticos utilizando anticorpos anti-tau.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462017789P | 2014-06-26 | 2014-06-26 | |
US201462017807P | 2014-06-26 | 2014-06-26 | |
US201462017746P | 2014-06-26 | 2014-06-26 | |
US201462017812P | 2014-06-26 | 2014-06-26 | |
EP14179719 | 2014-08-04 | ||
EP14179706 | 2014-08-04 | ||
EP14179699 | 2014-08-04 | ||
EP14179739 | 2014-08-04 | ||
PCT/EP2015/064533 WO2015197823A2 (en) | 2014-06-26 | 2015-06-26 | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016030183A2 true BR112016030183A2 (pt) | 2017-11-14 |
Family
ID=54937409
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016030183A BR112016030183A2 (pt) | 2014-06-26 | 2015-06-26 | anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos |
BR112016029579A BR112016029579A2 (pt) | 2014-06-26 | 2015-06-26 | anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016029579A BR112016029579A2 (pt) | 2014-06-26 | 2015-06-26 | anticorpos e fragmentos de ligação ao antígeno que se ligam especificamente à proteína tau associada a microtúbulos |
Country Status (13)
Country | Link |
---|---|
US (2) | US10400034B2 (pt) |
EP (3) | EP3160998B1 (pt) |
JP (2) | JP2017521063A (pt) |
KR (2) | KR20170023124A (pt) |
CN (2) | CN107074965B (pt) |
AU (3) | AU2015279086B2 (pt) |
BR (2) | BR112016030183A2 (pt) |
CA (2) | CA2952745A1 (pt) |
EA (2) | EA036307B1 (pt) |
NZ (2) | NZ727024A (pt) |
SG (2) | SG11201610459XA (pt) |
WO (2) | WO2015197820A1 (pt) |
ZA (1) | ZA201608811B (pt) |
Families Citing this family (24)
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SG10201707855YA (en) | 2013-03-13 | 2017-10-30 | Prothena Biosciences Ltd | Tau immunotherapy |
WO2015197820A1 (en) * | 2014-06-26 | 2015-12-30 | Crucell Holland B.V. | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
ZA201608812B (en) | 2014-06-26 | 2019-08-28 | Janssen Vaccines & Prevention Bv | Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau |
PE20190261A1 (es) | 2016-05-02 | 2019-02-25 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
CN109415432B (zh) | 2016-05-02 | 2022-07-08 | 普罗塞纳生物科学有限公司 | Tau免疫疗法 |
US10364286B2 (en) * | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
MA47499A (fr) | 2017-02-17 | 2019-12-25 | Denali Therapeutics Inc | Anticorps anti-tau et leurs procédés d'utilisation |
CN110418804A (zh) * | 2017-03-28 | 2019-11-05 | 扬森疫苗与预防公司 | 与tau特异性地结合的结合分子 |
WO2018195376A1 (en) * | 2017-04-21 | 2018-10-25 | Ohio University | Peptide-based inhibitors of mark family proteins |
BR112019022906A2 (pt) | 2017-05-02 | 2020-05-26 | Prothena Biosciences Limited | Anticorpos que reconhecem tau |
JP6851549B2 (ja) | 2017-10-16 | 2021-03-31 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗タウ抗体及びその使用 |
JP2021501147A (ja) * | 2017-10-25 | 2021-01-14 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | リン酸化タウペプチドの組成物およびその使用 |
US20200369754A1 (en) * | 2017-12-04 | 2020-11-26 | Janssen Vaccines & Prevention B.V. | Binding molecules that specifically bind to tau |
WO2019133799A1 (en) * | 2017-12-29 | 2019-07-04 | University Of Florida Research Foundation | Monoclonal antibodies targeting microtubule-binding domain of tau protein |
EA202091756A1 (ru) * | 2018-02-01 | 2020-10-28 | Янссен Вэксинс Энд Превеншн Б.В. | Связывающие молекулы, специфично связывающиеся с тау-белком |
CN112105639A (zh) * | 2018-03-05 | 2020-12-18 | 詹森药业有限公司 | 抗PHF-tau抗体及其用途 |
US20200408781A1 (en) | 2018-03-05 | 2020-12-31 | Gallen Triana-Baltzer | Assays to detect neurodegeneration |
EP3774889A4 (en) * | 2018-03-11 | 2021-12-08 | Koorosh Shahpasand | CONFORMITY INDEPENDENT ANTIBODIES AGAINST NEUROTOXIC TAU PROTEINS |
US20210347868A1 (en) * | 2018-10-19 | 2021-11-11 | Gabriel Pascual | Anti-synuclein antibodies |
EA202192203A1 (ru) | 2019-02-08 | 2021-10-20 | Ац Иммуне С.А. | СПОСОБ БЕЗОПАСНОГО ВВЕДЕНИЯ ВАКЦИНЫ ФОСФОРИЛИРОВАННОГО ПЕПТИДА Tau |
CU20210073A7 (es) | 2019-03-03 | 2022-04-07 | Prothena Biosciences Ltd | Anticuerpos que se unen dentro de la región de unión a microtúbulos de tau definida por cdrs |
CN114173812A (zh) | 2019-04-24 | 2022-03-11 | 杨森制药公司 | Tau疫苗的异源给予 |
GB2585252A (en) | 2019-07-05 | 2021-01-06 | Gen2 Neuroscience Ltd | Tau epitope and binding molecules |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
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-
2015
- 2015-06-26 WO PCT/EP2015/064529 patent/WO2015197820A1/en active Application Filing
- 2015-06-26 NZ NZ727024A patent/NZ727024A/en not_active IP Right Cessation
- 2015-06-26 KR KR1020177001941A patent/KR20170023124A/ko not_active Application Discontinuation
- 2015-06-26 CN CN201580034105.1A patent/CN107074965B/zh active Active
- 2015-06-26 BR BR112016030183A patent/BR112016030183A2/pt not_active Application Discontinuation
- 2015-06-26 KR KR1020177002193A patent/KR20170023151A/ko active IP Right Grant
- 2015-06-26 CA CA2952745A patent/CA2952745A1/en not_active Abandoned
- 2015-06-26 SG SG11201610459XA patent/SG11201610459XA/en unknown
- 2015-06-26 AU AU2015279086A patent/AU2015279086B2/en not_active Ceased
- 2015-06-26 CA CA2952741A patent/CA2952741A1/en not_active Abandoned
- 2015-06-26 JP JP2016575196A patent/JP2017521063A/ja active Pending
- 2015-06-26 EA EA201692394A patent/EA036307B1/ru not_active IP Right Cessation
- 2015-06-26 BR BR112016029579A patent/BR112016029579A2/pt not_active Application Discontinuation
- 2015-06-26 SG SG11201610446XA patent/SG11201610446XA/en unknown
- 2015-06-26 EA EA201692539A patent/EA035530B1/ru not_active IP Right Cessation
- 2015-06-26 NZ NZ727020A patent/NZ727020A/en not_active IP Right Cessation
- 2015-06-26 EP EP15731934.4A patent/EP3160998B1/en active Active
- 2015-06-26 US US15/321,918 patent/US10400034B2/en not_active Expired - Fee Related
- 2015-06-26 AU AU2015279089A patent/AU2015279089B2/en not_active Ceased
- 2015-06-26 WO PCT/EP2015/064533 patent/WO2015197823A2/en active Application Filing
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- 2015-06-26 EP EP15731936.9A patent/EP3160999B1/en active Active
- 2015-06-26 EP EP18199818.8A patent/EP3486256A3/en not_active Withdrawn
- 2015-06-26 CN CN201580034112.1A patent/CN107074935B/zh active Active
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2016
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