BR112016029074A2 - método para a fabricação de ácido 3-(alquil sulfonil)piridina-2-carboxílico - Google Patents

método para a fabricação de ácido 3-(alquil sulfonil)piridina-2-carboxílico

Info

Publication number
BR112016029074A2
BR112016029074A2 BR112016029074A BR112016029074A BR112016029074A2 BR 112016029074 A2 BR112016029074 A2 BR 112016029074A2 BR 112016029074 A BR112016029074 A BR 112016029074A BR 112016029074 A BR112016029074 A BR 112016029074A BR 112016029074 A2 BR112016029074 A2 BR 112016029074A2
Authority
BR
Brazil
Prior art keywords
represented
compound
formula
salt
alkylsulfonyl
Prior art date
Application number
BR112016029074A
Other languages
English (en)
Inventor
Maehata Ryota
Kimura Takahiro
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Publication of BR112016029074A2 publication Critical patent/BR112016029074A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • C07D213/807—Processes of preparation by oxidation of pyridines or condensed pyridines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/83—Thioacids; Thioesters; Thioamides; Thioimides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

um composto que pode ser representado pela fórmula (7) ou um seu sal pode ser fabricado por meio das seguintes etapas: uma etapa na qual um composto que pode ser representado pela fórmula (1-s) (em que r1 representa um grupo c1-8 alquila de cadeia reta e x representa um átomo de halogênio) e um composto que pode ser representado pela fórmula (2) (em que r2 representa um grupo c1-8 alquila de cadeia reta e m2 representa um átomo de hidrogênio ou um metal alcalino) são reagidos, produzindo um composto que pode ser representado pela fórmula (3-s) (em que r1, r2, e x têm os significados anteriormente mencionados); uma etapa em que o composto que pode ser representado pela fórmula (3-s) é reagido com o peróxido de hidrogênio, na presença de um catalisador de tungstênio e um ácido, produzindo um composto que pode ser representado pela fórmula (6-s) (em que x e r2 têm os significados anteriormente mencionados) ou um seu sal; e uma etapa em que o composto que pode ser representado pela fórmula (6-s) ou seu sal é reduzido, na presença de uma base e um catalisador de metal de transição heterogêneo, produzindo o composto que pode ser representado pela fórmula (7) (em que r2 tem o significado anteriormente mencionado) ou um seu sal. (1-s) (2) r2sm2 (3-s) (6-s) (7)
BR112016029074A 2014-06-26 2015-06-22 método para a fabricação de ácido 3-(alquil sulfonil)piridina-2-carboxílico BR112016029074A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014131041 2014-06-26
PCT/JP2015/067827 WO2015199006A1 (ja) 2014-06-26 2015-06-22 ３－（アルキルスルホニル）ピリジン－２－カルボン酸の製造方法

Publications (1)

Publication Number Publication Date
BR112016029074A2 true BR112016029074A2 (pt) 2017-08-22

Family

ID=54938089

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016029074A BR112016029074A2 (pt) 2014-06-26 2015-06-22 método para a fabricação de ácido 3-(alquil sulfonil)piridina-2-carboxílico

Country Status (12)

Country Link
US (2) US9850209B2 (pt)
EP (1) EP3162795B1 (pt)
JP (2) JP6528772B2 (pt)
KR (1) KR102332262B1 (pt)
CN (2) CN106660958B (pt)
AU (1) AU2015281846B2 (pt)
BR (1) BR112016029074A2 (pt)
DE (1) DE112015003036T5 (pt)
IL (1) IL249296B (pt)
RU (1) RU2017101814A (pt)
TW (1) TWI659020B (pt)
WO (2) WO2015199007A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202134214A (zh) * 2020-03-04 2021-09-16 瑞士商先正達農作物保護公司 用於製備具有3-含硫取代基的5-氯-吡啶-2-甲酸醯胺以及甲酸鹽之方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4558134A (en) * 1983-01-03 1985-12-10 The Dow Chemical Company Certain phenoxy-pyridine-carbonitriles having antiviral activity
CH657124A5 (en) 1983-08-10 1986-08-15 Lonza Ag 3-Chloroisocinchomeronoyl chloride and a process for its preparation
IL91083A (en) * 1988-07-25 1993-04-04 Ciba Geigy Cyclohexanedione derivatives, their preparation and their use as herbicides
WO2007016358A1 (en) * 2005-08-02 2007-02-08 Merck & Co., Inc. N-(pyridin-4-yl)-2-phenylbutanamides as androgen receptor modulators
CA2643859A1 (en) 2006-03-10 2007-09-20 Boehringer Ingelheim International Gmbh Soluble epoxide hydrolase inhibitors and methods of using same
TWI545119B (zh) * 2011-08-04 2016-08-11 住友化學股份有限公司 稠合雜環化合物及其在病蟲害防制上之用途
KR102115128B1 (ko) 2012-12-27 2020-05-26 수미토모 케미칼 컴퍼니 리미티드 융합된 옥사졸 화합물 및 그의 해충 방제를 위한 용도

Also Published As

Publication number Publication date
RU2017101814A (ru) 2018-08-02
JPWO2015199006A1 (ja) 2017-04-20
US9850209B2 (en) 2017-12-26
TWI659020B (zh) 2019-05-11
CN106458907B (zh) 2018-12-11
IL249296B (en) 2019-11-28
KR102332262B1 (ko) 2021-11-26
TW201605803A (zh) 2016-02-16
IL249296A0 (en) 2017-02-28
EP3162795A1 (en) 2017-05-03
JP6500898B2 (ja) 2019-04-17
KR20170023963A (ko) 2017-03-06
RU2017101814A3 (pt) 2019-01-15
AU2015281846A1 (en) 2017-02-02
US20170166529A1 (en) 2017-06-15
CN106660958B (zh) 2019-04-12
EP3162795A4 (en) 2018-02-28
JPWO2015199007A1 (ja) 2017-04-20
WO2015199006A1 (ja) 2015-12-30
US9815786B2 (en) 2017-11-14
US20170129859A1 (en) 2017-05-11
EP3162795B1 (en) 2019-07-31
JP6528772B2 (ja) 2019-06-12
CN106660958A (zh) 2017-05-10
CN106458907A (zh) 2017-02-22
WO2015199007A1 (ja) 2015-12-30
DE112015003036T5 (de) 2017-03-16
AU2015281846B2 (en) 2019-08-01

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