BR112016028741A2 - composições e métodos para controle de fluxo rápido e dinâmico usando válvulas metabólicas sintéticas - Google Patents

composições e métodos para controle de fluxo rápido e dinâmico usando válvulas metabólicas sintéticas

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Publication number
BR112016028741A2
BR112016028741A2 BR112016028741A BR112016028741A BR112016028741A2 BR 112016028741 A2 BR112016028741 A2 BR 112016028741A2 BR 112016028741 A BR112016028741 A BR 112016028741A BR 112016028741 A BR112016028741 A BR 112016028741A BR 112016028741 A2 BR112016028741 A2 BR 112016028741A2
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Brazil
Prior art keywords
strains
metabolism
compositions
fast
methods
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BR112016028741A
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English (en)
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Bozdag Ahmet
Delanie Trahan Ashley
Bridwell Cooper Charles
Rodriguez Daniel
David Lynch Michael
Ye Zhixia
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Univ Duke
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Publication of BR112016028741A2 publication Critical patent/BR112016028741A2/pt

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Abstract

a presente invenção refere-se a micro-organismos metabolicamente modificados, tais como cepas bacterianas e/ou fúngicas, e a bioprocessos utilizando tais cepas. esta cepas possibilitam o controle dinâmico de vias metabólicas, que podem ser usadas para otimizar a produção. o controle dinâmico sobre o metabolismo é efetuado via uma combinação de metodologias incluindo, porém sem limitação, silenciamento transcricional e proteólise controlada de enzimas. essas cepas microbianas são utilizados em um bioprocesso multiestágios compreendendo pelo menos dois estágios, o primeiro estágio no qual os micro-organismos são cultivados e o metabolismo pode ser otimizado para crescimento microbiano e pelo menos um outro estágio no qual o crescimento pode ser desacelerado ou interrompido, e alterações dinâmicas podem ser feitas no metabolismo para aumentar a produção do produto desejado, tal como uma substância química ou combustível.
BR112016028741A 2014-06-11 2015-06-11 composições e métodos para controle de fluxo rápido e dinâmico usando válvulas metabólicas sintéticas BR112016028741A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462010574P 2014-06-11 2014-06-11
PCT/US2015/035306 WO2016053397A2 (en) 2014-06-11 2015-06-11 Compositions and methods for rapid and dynamic flux control using synthetic metabolic valves

Publications (1)

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BR112016028741A2 true BR112016028741A2 (pt) 2017-11-07

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