BR112016022175A2 - dispositivo e método para preparar e administrar um selante de fibrina de componente único - Google Patents

dispositivo e método para preparar e administrar um selante de fibrina de componente único

Info

Publication number
BR112016022175A2
BR112016022175A2 BR112016022175A BR112016022175A BR112016022175A2 BR 112016022175 A2 BR112016022175 A2 BR 112016022175A2 BR 112016022175 A BR112016022175 A BR 112016022175A BR 112016022175 A BR112016022175 A BR 112016022175A BR 112016022175 A2 BR112016022175 A2 BR 112016022175A2
Authority
BR
Brazil
Prior art keywords
preparing
mixture
container
administering
fibrin sealant
Prior art date
Application number
BR112016022175A
Other languages
English (en)
Inventor
Deangelis Ashley
Erez Lior
Doron Sivan
Pilpel Yair
Zherdev Yuri
Original Assignee
Ethicon Inc
Omrix Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc, Omrix Biopharmaceuticals Ltd filed Critical Ethicon Inc
Publication of BR112016022175A2 publication Critical patent/BR112016022175A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00491—Surgical glue applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00—Medical syringes, e.g. enemata; Irrigators
    • A61M3/005—Medical syringes, e.g. enemata; Irrigators comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0445—Proteins
    • A61M2202/0447—Glycoproteins
    • A61M2202/045—Fibrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Surgical Instruments (AREA)

Abstract

a presente invenção refere-se a sistemas para preparar e fornecer selante de fibrina para uma superfície e métodos para uso do mesmo. em uma modalidade, o sistema compreende: a. uma quantidade de uma mistura líquida disposta dentro de um recipiente (120), em que a mistura compreende: i. fibrina ou ii. fibrinogênio e fator ii; e b. um leito de resina (160) disposto dentro de um vaso (158), sendo que o vaso (158) é capaz de estar em comunicação fluida com o recipiente (120), em que quando em comunicação fluida, a passagem da mistura através do recipiente (158) resulta na modificação da concentração de inibidor(es) de pequenas moléculas e/ou indutor(es) dentro da mistura, favorecendo a formação de coágulo de fibrina.
BR112016022175A 2014-03-27 2015-03-25 dispositivo e método para preparar e administrar um selante de fibrina de componente único BR112016022175A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970929P 2014-03-27 2014-03-27
IL231792A IL231792A0 (en) 2014-03-27 2014-03-27 Device and method for the preparation and administration of one-component fibrin glue
PCT/IL2015/000018 WO2015145416A1 (en) 2014-03-27 2015-03-25 Device and method for preparing and administering one-component fibrin sealant

Publications (1)

Publication Number Publication Date
BR112016022175A2 true BR112016022175A2 (pt) 2017-10-10

Family

ID=51418150

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016022175A BR112016022175A2 (pt) 2014-03-27 2015-03-25 dispositivo e método para preparar e administrar um selante de fibrina de componente único

Country Status (9)

Country Link
US (3) US10433825B2 (pt)
EP (1) EP3122260A1 (pt)
JP (1) JP6479846B2 (pt)
CN (1) CN106456719B (pt)
AU (1) AU2015237745B2 (pt)
BR (1) BR112016022175A2 (pt)
CA (1) CA2943928A1 (pt)
IL (2) IL231792A0 (pt)
WO (1) WO2015145416A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
IL234246A0 (en) * 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
CN113438928A (zh) * 2019-03-06 2021-09-24 甘布罗伦迪亚股份公司 用于递送凝血酶激活的纤维蛋白密封剂的装置和方法
CN110361531B (zh) * 2019-08-02 2023-04-11 天津医科大学总医院 一种检测微粒促凝活性的实验方法
WO2022064478A1 (en) * 2020-09-23 2022-03-31 Omrix Biopharmaceuticals Ltd. Hemostatic formulations and uses thereof

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US4627879A (en) 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
DE3622642A1 (de) 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
US4978336A (en) 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
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Also Published As

Publication number Publication date
CN106456719A (zh) 2017-02-22
US20190314006A1 (en) 2019-10-17
US11020100B2 (en) 2021-06-01
US20210267581A1 (en) 2021-09-02
IL247425A0 (en) 2016-11-30
JP2017514554A (ja) 2017-06-08
EP3122260A1 (en) 2017-02-01
US10433825B2 (en) 2019-10-08
AU2015237745B2 (en) 2019-08-29
WO2015145416A1 (en) 2015-10-01
US11957324B2 (en) 2024-04-16
IL247425B (en) 2020-11-30
US20150272562A1 (en) 2015-10-01
JP6479846B2 (ja) 2019-03-06
AU2015237745A1 (en) 2016-09-15
IL231792A0 (en) 2014-08-31
CN106456719B (zh) 2020-02-14
CA2943928A1 (en) 2015-10-01

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]