BR112016007620B1 - Composto, medicamento, e, uso de um composto - Google Patents
Composto, medicamento, e, uso de um composto Download PDFInfo
- Publication number
- BR112016007620B1 BR112016007620B1 BR112016007620-6A BR112016007620A BR112016007620B1 BR 112016007620 B1 BR112016007620 B1 BR 112016007620B1 BR 112016007620 A BR112016007620 A BR 112016007620A BR 112016007620 B1 BR112016007620 B1 BR 112016007620B1
- Authority
- BR
- Brazil
- Prior art keywords
- group
- compound
- methyl
- mixture
- added
- Prior art date
Links
- 0 *N(CCc1cccc(I)c11)C1=N Chemical compound *N(CCc1cccc(I)c11)C1=N 0.000 description 20
- HPHOTMAANBODEF-UHFFFAOYSA-N CCC(CC(C1CC1)C(C1)C(CC2)=CCC2F)=C1OC(C)C Chemical compound CCC(CC(C1CC1)C(C1)C(CC2)=CCC2F)=C1OC(C)C HPHOTMAANBODEF-UHFFFAOYSA-N 0.000 description 1
- PMNGZEUPFDVTOL-QXMHVHEDSA-N CCCCC/C(/Cl)=C(\CC)/CCC Chemical compound CCCCC/C(/Cl)=C(\CC)/CCC PMNGZEUPFDVTOL-QXMHVHEDSA-N 0.000 description 1
- JGFZNNIVVJXRND-UHFFFAOYSA-N CCN(C(C)C)C(C)C Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 1
- YUFCCURGZSXQAI-UHFFFAOYSA-N COC(C1)C1c(cc1C([O]=C)=O)cnc1I Chemical compound COC(C1)C1c(cc1C([O]=C)=O)cnc1I YUFCCURGZSXQAI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013209826 | 2013-10-07 | ||
| JP2013-209826 | 2013-10-07 | ||
| PCT/JP2014/005075 WO2015052910A1 (en) | 2013-10-07 | 2014-10-06 | Antagonists of somatostatin receptor subtype 5 (sstr5) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016007620A2 BR112016007620A2 (pt) | 2017-08-01 |
| BR112016007620B1 true BR112016007620B1 (pt) | 2020-05-26 |
Family
ID=51842719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016007620-6A BR112016007620B1 (pt) | 2013-10-07 | 2014-10-06 | Composto, medicamento, e, uso de um composto |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9353108B2 (ar) |
| EP (1) | EP3055309B1 (ar) |
| JP (1) | JP6411520B2 (ar) |
| CN (1) | CN105612158B (ar) |
| AR (1) | AR097932A1 (ar) |
| BR (1) | BR112016007620B1 (ar) |
| CA (1) | CA2926544C (ar) |
| CY (1) | CY1121163T1 (ar) |
| DK (1) | DK3055309T3 (ar) |
| ES (1) | ES2687102T3 (ar) |
| HR (1) | HRP20181372T1 (ar) |
| HU (1) | HUE039386T2 (ar) |
| JO (1) | JO3442B1 (ar) |
| LT (1) | LT3055309T (ar) |
| PL (1) | PL3055309T3 (ar) |
| PT (1) | PT3055309T (ar) |
| RS (1) | RS57743B1 (ar) |
| RU (1) | RU2671958C2 (ar) |
| SI (1) | SI3055309T1 (ar) |
| TR (1) | TR201810506T4 (ar) |
| TW (1) | TWI648276B (ar) |
| UY (1) | UY35774A (ar) |
| WO (1) | WO2015052910A1 (ar) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014142363A1 (en) * | 2013-03-14 | 2014-09-18 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as sstr5 antagonists |
| CN107001332B (zh) * | 2014-12-02 | 2020-05-15 | 豪夫迈·罗氏有限公司 | 哌啶衍生物 |
| TW201712012A (zh) | 2015-06-16 | 2017-04-01 | 美國禮來大藥廠 | ２－側氧基－１，３，８－三氮雜螺［４．５］癸－３－基羧酸衍生物 |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| TW202207929A (zh) * | 2020-05-13 | 2022-03-01 | 日商思可海雅藥品股份有限公司 | 膽道系疾病的診斷輔助、預防或治療劑 |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| CN116354961A (zh) * | 2021-12-27 | 2023-06-30 | 中国科学院上海药物研究所 | 生长抑素受体5拮抗剂及其药物组合物及用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5356906A (en) | 1989-10-27 | 1994-10-18 | The Du Pont Merck Pharmaceutical Company | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis |
| WO1997010224A1 (en) | 1995-09-13 | 1997-03-20 | Takeda Chemical Industries, Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
| WO2002006234A1 (fr) | 2000-07-17 | 2002-01-24 | Takeda Chemical Industries, Ltd. | Derives de sulfonate, procede de production et utilisation de ces derives |
| MXPA04002249A (es) | 2001-09-24 | 2004-06-29 | Bayer Pharmaceuticals Corp | Preparacion y uso de derivados de 1,5,6,7,-tetrahidro-pirrolo[3,2-c]piridina para el tratamiento de la obesidad. |
| CN1578781A (zh) * | 2001-09-26 | 2005-02-09 | 拜尔药品公司 | 用作抗糖尿病药物的1,8－萘啶衍生物 |
| TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
| TW200416029A (en) | 2002-11-01 | 2004-09-01 | Takeda Chemical Industries Ltd | Agent for preventing or treating neuropathy |
| AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| US20070004736A1 (en) | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| BRPI0408332A (pt) | 2003-03-14 | 2006-03-21 | Ono Pharmaceutical Co | derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo |
| EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONNECTION WITH CONDENSED RING |
| WO2005030740A1 (ja) | 2003-09-30 | 2005-04-07 | Takeda Pharmaceutical Company Limited | チアゾリン誘導体およびその用途 |
| AU2004289690A1 (en) | 2003-11-10 | 2005-05-26 | Schering Aktiengesellschaft | Benzylether amine compounds useful as CCR-5 antagonists |
| US7820673B2 (en) | 2003-12-17 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Urea derivative, process for producing the same, and use |
| BRPI0418148A (pt) | 2003-12-25 | 2007-04-17 | Takeda Pharmaceutical | composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto |
| WO2005063725A1 (ja) | 2003-12-26 | 2005-07-14 | Takeda Pharmaceutical Company Limited | フェニルプロパン酸誘導体 |
| JP4875978B2 (ja) | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
| JP4859665B2 (ja) | 2004-03-30 | 2012-01-25 | 武田薬品工業株式会社 | アルコキシフェニルプロパン酸誘導体 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| JPWO2007013694A1 (ja) | 2005-07-29 | 2009-02-12 | 武田薬品工業株式会社 | フェノキシアルカン酸化合物 |
| JP5084503B2 (ja) | 2005-07-29 | 2012-11-28 | 武田薬品工業株式会社 | シクロプロパンカルボン酸化合物 |
| TW200740435A (en) | 2005-08-10 | 2007-11-01 | Takeda Pharmaceuticals Co | Therapeutic agent for diabetes |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| RS52307B (en) | 2006-06-27 | 2012-12-31 | Takeda Pharmaceutical Company Limited | CONDENSED CYCLIC UNITS |
| CN101506165B (zh) | 2006-08-15 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | 苯基、吡啶和喹啉衍生物 |
| US8492405B2 (en) | 2006-10-18 | 2013-07-23 | Takeda Pharmaceutical Company Limited | Glucokinase-activating fused heterocyclic compounds and methods of treating diabetes and obesity |
| KR101444486B1 (ko) | 2006-10-19 | 2014-09-24 | 다케다 야쿠힌 고교 가부시키가이샤 | 인돌 화합물 |
| EP2128138A1 (en) | 2007-01-29 | 2009-12-02 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
| EA200970746A1 (ru) | 2007-02-09 | 2010-02-26 | Такеда Фармасьютикал Компани Лимитед | Конденсированные циклические соединения в качестве частичных агонистов ppar-гамма |
| US7862825B2 (en) | 2007-02-21 | 2011-01-04 | Mladen Vranic | Method of controlling tight blood glucose by somatostatin receptor antagonists |
| US7799806B2 (en) | 2007-04-04 | 2010-09-21 | Hoffmann-La Roche Inc. | Substituted n-benzyl piperidines as somatostatin receptor modulators |
| US8318746B2 (en) | 2007-04-27 | 2012-11-27 | Takeda Pharmaceutical Company Limited | Nitrogen-containing five-membered heterocyclic compound |
| US20080306116A1 (en) * | 2007-06-08 | 2008-12-11 | Christ Andreas D | Aryloxazole, aryloxadiazole and benzimidazole derivatives |
| WO2008156757A1 (en) | 2007-06-19 | 2008-12-24 | Takeda Pharmaceutical Company Limited | Indazole compounds for activating glucokinase |
| TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| CA2759651A1 (en) * | 2009-05-07 | 2010-11-11 | Merck Sharp & Dohme Corp. | Substituted spirocyclic amines useful as antidiabetic compounds |
| WO2012024183A1 (en) | 2010-08-18 | 2012-02-23 | Merck Sharp & Dohme Corp. | Spiroxazolidinone compounds |
| EP2643311A1 (en) | 2010-11-26 | 2013-10-02 | Lupin Limited | Bicyclic gpr119 modulators |
| WO2014142363A1 (en) | 2013-03-14 | 2014-09-18 | Takeda Pharmaceutical Company Limited | Spiro azetidine isoxazole derivatives and their use as sstr5 antagonists |
| AR098215A1 (es) | 2013-10-29 | 2016-05-18 | Takeda Pharmaceuticals Co | Compuesto heterocíclico |
-
2014
- 2014-10-02 JO JOP/2014/0283A patent/JO3442B1/ar active
- 2014-10-03 US US14/505,907 patent/US9353108B2/en active Active
- 2014-10-06 AR ARP140103713A patent/AR097932A1/es active IP Right Grant
- 2014-10-06 RU RU2016117732A patent/RU2671958C2/ru active
- 2014-10-06 WO PCT/JP2014/005075 patent/WO2015052910A1/en active Application Filing
- 2014-10-06 EP EP14790746.3A patent/EP3055309B1/en active Active
- 2014-10-06 PL PL14790746T patent/PL3055309T3/pl unknown
- 2014-10-06 ES ES14790746.3T patent/ES2687102T3/es active Active
- 2014-10-06 TW TW103134715A patent/TWI648276B/zh active
- 2014-10-06 BR BR112016007620-6A patent/BR112016007620B1/pt active IP Right Grant
- 2014-10-06 LT LTEP14790746.3T patent/LT3055309T/lt unknown
- 2014-10-06 CA CA2926544A patent/CA2926544C/en active Active
- 2014-10-06 HU HUE14790746A patent/HUE039386T2/hu unknown
- 2014-10-06 JP JP2016546198A patent/JP6411520B2/ja active Active
- 2014-10-06 TR TR2018/10506T patent/TR201810506T4/tr unknown
- 2014-10-06 RS RS20181007A patent/RS57743B1/sr unknown
- 2014-10-06 PT PT14790746T patent/PT3055309T/pt unknown
- 2014-10-06 CN CN201480055324.3A patent/CN105612158B/zh active Active
- 2014-10-06 SI SI201430838T patent/SI3055309T1/sl unknown
- 2014-10-06 UY UY0001035774A patent/UY35774A/es not_active Application Discontinuation
- 2014-10-06 DK DK14790746.3T patent/DK3055309T3/en active
-
2016
- 2016-04-27 US US15/139,531 patent/US9751878B2/en active Active
-
2018
- 2018-08-27 HR HRP20181372TT patent/HRP20181372T1/hr unknown
- 2018-09-04 CY CY20181100912T patent/CY1121163T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3055309T3 (en) | 2018-08-27 |
| US9353108B2 (en) | 2016-05-31 |
| TWI648276B (zh) | 2019-01-21 |
| PT3055309T (pt) | 2018-10-01 |
| US20160237087A1 (en) | 2016-08-18 |
| UY35774A (es) | 2015-05-29 |
| US20150099777A1 (en) | 2015-04-09 |
| US9751878B2 (en) | 2017-09-05 |
| SI3055309T1 (sl) | 2018-10-30 |
| RU2671958C2 (ru) | 2018-11-08 |
| CY1121163T1 (el) | 2020-05-29 |
| PL3055309T3 (pl) | 2018-10-31 |
| LT3055309T (lt) | 2018-08-27 |
| ES2687102T3 (es) | 2018-10-23 |
| EP3055309A1 (en) | 2016-08-17 |
| BR112016007620A2 (pt) | 2017-08-01 |
| CN105612158B (zh) | 2017-06-30 |
| TW201536784A (zh) | 2015-10-01 |
| WO2015052910A1 (en) | 2015-04-16 |
| TR201810506T4 (tr) | 2018-08-27 |
| EP3055309B1 (en) | 2018-06-13 |
| JP2016531950A (ja) | 2016-10-13 |
| JP6411520B2 (ja) | 2018-10-24 |
| HRP20181372T1 (hr) | 2018-10-19 |
| RS57743B1 (sr) | 2018-12-31 |
| HUE039386T2 (hu) | 2018-12-28 |
| AR097932A1 (es) | 2016-04-20 |
| CA2926544C (en) | 2021-07-06 |
| CA2926544A1 (en) | 2015-04-16 |
| JO3442B1 (ar) | 2019-10-20 |
| RU2016117732A (ru) | 2017-11-15 |
| CN105612158A (zh) | 2016-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/10/2014, OBSERVADAS AS CONDICOES LEGAIS. |