BR112016002078A2 - Procédé de préparation de composés morphinan-6-ones - Google Patents
Procédé de préparation de composés morphinan-6-onesInfo
- Publication number
- BR112016002078A2 BR112016002078A2 BR112016002078A BR112016002078A BR112016002078A2 BR 112016002078 A2 BR112016002078 A2 BR 112016002078A2 BR 112016002078 A BR112016002078 A BR 112016002078A BR 112016002078 A BR112016002078 A BR 112016002078A BR 112016002078 A2 BR112016002078 A2 BR 112016002078A2
- Authority
- BR
- Brazil
- Prior art keywords
- composés
- morphinan
- procédé
- ones
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1313915.9A GB201313915D0 (en) | 2013-08-02 | 2013-08-02 | Process |
| PCT/GB2014/050324 WO2015015147A1 (en) | 2013-08-02 | 2014-02-05 | Process for the preparation of morphinan-6-one compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016002078A2 true BR112016002078A2 (pt) | 2017-09-05 |
Family
ID=49224110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016002078A BR112016002078A2 (pt) | 2013-08-02 | 2014-02-05 | Procédé de préparation de composés morphinan-6-ones |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9908891B2 (pt) |
| EP (2) | EP3027621A1 (pt) |
| CN (1) | CN105452254B (pt) |
| AU (1) | AU2014298258B2 (pt) |
| BR (1) | BR112016002078A2 (pt) |
| CA (1) | CA2919606C (pt) |
| GB (2) | GB201313915D0 (pt) |
| RU (1) | RU2652786C2 (pt) |
| WO (1) | WO2015015147A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3166948A1 (en) | 2014-07-09 | 2017-05-17 | Rhodes Technologies Inc. | Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions |
| CN107033155B (zh) * | 2016-02-04 | 2019-04-26 | 国药集团国瑞药业有限公司 | 一种吗啡酮类化合物的立体选择性还原方法 |
| EP3252055B1 (en) | 2016-05-31 | 2018-09-19 | Alcaliber Investigacion Desarrollo e Innovacion SLU | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
| AU2018287728B2 (en) | 2017-06-20 | 2021-10-28 | Macfarlan Smith Limited | Hydrogenation process for preparing oxycodone hydrochloride from 14-hydroxycodeinone |
| EP3495371A1 (en) | 2017-12-05 | 2019-06-12 | Siegfried AG | Synthesis of noroxymorphone |
| CN108164540B (zh) * | 2017-12-14 | 2019-08-13 | 宜昌人福药业有限责任公司 | 一种合成氢吗啡酮的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254088A (en) | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
| DE2205225A1 (de) * | 1972-02-04 | 1973-08-09 | Hoechst Ag | Verfahren zur herstellung von 3-hydroxycyclohexanon |
| US4272541A (en) * | 1978-06-02 | 1981-06-09 | Miles Laboratories, Inc. | 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them |
| US4861921A (en) | 1986-03-18 | 1989-08-29 | Catalytica Associates | Process for manufacture of resorcinol |
| JP4879740B2 (ja) | 2003-09-22 | 2012-02-22 | ジョンソン、マッセイ、パブリック、リミテッド、カンパニー | モルヒナン化合物およびその中間体の合成法 |
| TWI483944B (zh) * | 2004-03-30 | 2015-05-11 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| GB0421687D0 (en) | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
| WO2006084389A1 (de) * | 2005-02-11 | 2006-08-17 | Cilag Ltd. | Verfahren zur reinigung von noroxymorphon-verbindungen |
| MX2008010921A (es) * | 2006-03-02 | 2008-09-03 | Mallinckrodt Inc | Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados. |
| AU2007329451B2 (en) | 2006-12-04 | 2012-08-30 | Noramco, Llc | Process for reducing impurities in oxycodone base |
| GB0624880D0 (en) * | 2006-12-14 | 2007-01-24 | Johnson Matthey Plc | Improved method for making analgesics |
| US20080206883A1 (en) * | 2007-02-26 | 2008-08-28 | Cody Laboratories, Inc. | Hplc method for separation and detection of hydromorphone and related opioid pharmacophores |
| CA2681740A1 (en) * | 2007-03-23 | 2008-10-02 | Mallinckrodt Inc. | Improved preparation of oxymorphone from oripavine |
| EP2062896A1 (en) * | 2007-11-26 | 2009-05-27 | Siegfried Ltd. | Demethylation of 14-hydroxy substituted alkaloid derivatives |
| CN102046631A (zh) * | 2008-03-31 | 2011-05-04 | 阳光医药工业有限公司 | 制备吗啡烷类似物的改良方法 |
| US9073934B2 (en) * | 2009-09-16 | 2015-07-07 | Monash University | Method for the N-demethylation of N-methyl heterocycles |
| AR083150A1 (es) | 2010-05-10 | 2013-02-06 | Euro Celtique Sa | Composiciones farmaceuticas que comprenden hidromorfona y naloxona |
| CA2802294C (en) * | 2010-06-11 | 2016-05-10 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| WO2012003468A1 (en) * | 2010-07-02 | 2012-01-05 | Johnson Matthey Public Limited Company | Process for the synthesis and purification of oxycodone |
| JP6046119B2 (ja) * | 2011-05-02 | 2016-12-14 | ブロック ユニバーシティ | 脱水環化試薬を使用するｎ−オキシドのｎ−脱メチル化によるモルヒネ類似体の調製における方法および中間体 |
| US9657029B2 (en) * | 2012-06-11 | 2017-05-23 | Siegfried Generics International Ag | Method of preparing oxymorphone |
| GB2519486A (en) * | 2012-08-03 | 2015-04-22 | Johnson Matthey Plc | A method for preparing oxycodone |
| BR112016002079A2 (pt) * | 2013-08-02 | 2017-09-05 | Johnson Matthey Plc | Processo para preparação de um aditivo ácido de oximorfona, solução aquosa de aditivo ácido de oximorfona, aditivo ácido de oximorfona sólido, e, alcaloide de oximorfona sólido |
-
2013
- 2013-08-02 GB GBGB1313915.9A patent/GB201313915D0/en not_active Ceased
-
2014
- 2014-02-05 AU AU2014298258A patent/AU2014298258B2/en active Active
- 2014-02-05 BR BR112016002078A patent/BR112016002078A2/pt not_active Application Discontinuation
- 2014-02-05 WO PCT/GB2014/050324 patent/WO2015015147A1/en active Application Filing
- 2014-02-05 RU RU2016107381A patent/RU2652786C2/ru active
- 2014-02-05 GB GB1401963.2A patent/GB2517001B/en active Active
- 2014-02-05 EP EP14704633.8A patent/EP3027621A1/en not_active Ceased
- 2014-02-05 CA CA2919606A patent/CA2919606C/en active Active
- 2014-02-05 EP EP22204999.1A patent/EP4174072A3/en not_active Withdrawn
- 2014-02-05 US US14/909,573 patent/US9908891B2/en active Active
- 2014-02-05 CN CN201480043663.XA patent/CN105452254B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015015147A1 (en) | 2015-02-05 |
| CN105452254A (zh) | 2016-03-30 |
| RU2016107381A (ru) | 2017-09-07 |
| EP4174072A3 (en) | 2023-07-19 |
| GB201313915D0 (en) | 2013-09-18 |
| CA2919606A1 (en) | 2015-02-05 |
| EP3027621A1 (en) | 2016-06-08 |
| US20160176887A1 (en) | 2016-06-23 |
| EP4174072A2 (en) | 2023-05-03 |
| CA2919606C (en) | 2021-05-11 |
| RU2652786C2 (ru) | 2018-05-03 |
| AU2014298258B2 (en) | 2018-03-08 |
| GB2517001A (en) | 2015-02-11 |
| US9908891B2 (en) | 2018-03-06 |
| AU2014298258A1 (en) | 2016-02-18 |
| GB2517001B (en) | 2018-03-07 |
| CN105452254B (zh) | 2018-07-31 |
| GB201401963D0 (en) | 2014-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: C07D 489/08 Ipc: C07D 489/08 (2006.01), A61P 25/04 (2006.01) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |