BR112016001107A2 - Composto modulador de mglu5 4-(3-cianofenil)-6-piridinil pirimidina, usos terapêuticos do mesmo, composição farmacêutica compreendendo dito composto e método para produzí-lo - Google Patents

Composto modulador de mglu5 4-(3-cianofenil)-6-piridinil pirimidina, usos terapêuticos do mesmo, composição farmacêutica compreendendo dito composto e método para produzí-lo

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Publication number
BR112016001107A2
BR112016001107A2 BR112016001107A BR112016001107A BR112016001107A2 BR 112016001107 A2 BR112016001107 A2 BR 112016001107A2 BR 112016001107 A BR112016001107 A BR 112016001107A BR 112016001107 A BR112016001107 A BR 112016001107A BR 112016001107 A2 BR112016001107 A2 BR 112016001107A2
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BR
Brazil
Prior art keywords
compound
mglu5
cyanophenyl
producing
pharmaceutical composition
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BR112016001107A
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English (en)
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BR112016001107B1 (pt
BR112016001107A8 (pt
Inventor
Joanne Aves Sarah
Andrew Christopher John
Stuart Congreve Miles
Gerald Tehan Benjamin
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Heptares Therapeutics Ltd
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Publication of BR112016001107A2 publication Critical patent/BR112016001107A2/pt
Publication of BR112016001107A8 publication Critical patent/BR112016001107A8/pt
Publication of BR112016001107B1 publication Critical patent/BR112016001107B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P1/10—Laxatives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

MODULADORES DE MGLU5 4-(3-CIANOFENIL)-6-PIRIDINIL PIRIMIDINA. As revelações referem-se a compostos inovadores de fórmula em que R1, R2, R3 e R4 e n são definidos no presente documento, e a seu uso no tratamento, prevenção, melhora, controle ou redução do risco de inflamação, distúrbios neurológicos ou psiquiátricos associados à modulação da função do receptor mGlu5.
BR112016001107-4A 2013-07-17 2014-07-17 Composto modulador de mglu5 4-(3-cianofenil)-6-piridinil pirimidina, usos terapêuticos do mesmo, composição farmacêutica compreendendo dito composto e método para produzí-lo BR112016001107B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1312800.4 2013-07-17
GBGB1312800.4A GB201312800D0 (en) 2013-07-17 2013-07-17 mGlu5 modulators
PCT/GB2014/052184 WO2015008073A1 (en) 2013-07-17 2014-07-17 4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 modulators

Publications (3)

Publication Number Publication Date
BR112016001107A2 true BR112016001107A2 (pt) 2017-09-05
BR112016001107A8 BR112016001107A8 (pt) 2018-01-30
BR112016001107B1 BR112016001107B1 (pt) 2022-12-06

Family

ID=49081419

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016001107-4A BR112016001107B1 (pt) 2013-07-17 2014-07-17 Composto modulador de mglu5 4-(3-cianofenil)-6-piridinil pirimidina, usos terapêuticos do mesmo, composição farmacêutica compreendendo dito composto e método para produzí-lo

Country Status (11)

Country Link
US (7) US9676745B2 (pt)
EP (1) EP3022189B1 (pt)
JP (1) JP6346666B2 (pt)
CN (2) CN105377832B (pt)
AU (2) AU2014291807B2 (pt)
BR (1) BR112016001107B1 (pt)
CA (1) CA2917450C (pt)
ES (1) ES2699780T3 (pt)
GB (2) GB201312800D0 (pt)
SG (1) SG11201510738SA (pt)
WO (1) WO2015008073A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201312800D0 (en) * 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
WO2019072617A1 (en) 2017-10-13 2019-04-18 Cynora Gmbh ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES
WO2023249789A1 (en) * 2022-06-24 2023-12-28 Tempero Bio, Inc. Methods of treating substance use disorder with 4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 negative allosteric modulators

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KR100860827B1 (ko) * 2000-09-06 2008-09-30 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 글리코겐 합성효소 키나아제 3의 억제제
AU2002359714B2 (en) * 2001-12-18 2006-12-21 Merck Sharp & Dohme Corp. Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5
US7105548B2 (en) * 2001-12-18 2006-09-12 Merck & Co., Inc. Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5
WO2004084824A2 (en) 2003-03-24 2004-10-07 Merck & Co., Inc. Biaryl substituted 6-membered heterocyles as sodium channel blockers
DE10315573A1 (de) 2003-04-05 2004-10-14 Merck Patent Gmbh Substituierte Pyrazole
ES2303969T3 (es) 2003-12-19 2008-09-01 Astrazeneca Ab 5-fluoro- y cloro-piridin-2-il-tetrazoles como ligandos del receptor metabotropico de glutamato de tipo 5.
ATE402935T1 (de) * 2004-02-18 2008-08-15 Astrazeneca Ab Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen rezeptors zur behandlung von gastrointestinalen erkrankungen
UA82435C2 (uk) * 2004-02-18 2008-04-10 Astrazeneca Ab Конденсовані гетероциклічні сполуки та їх застосування як метаботропних антагоністів рецепторів глутамату, фармацевтична композиція на їх основі
WO2009011850A2 (en) 2007-07-16 2009-01-22 Abbott Laboratories Novel therapeutic compounds
US8536186B2 (en) 2008-08-04 2013-09-17 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MX2012008346A (es) 2010-01-25 2012-11-12 Chdi Foundation Inc Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos.
BR112012033658A2 (pt) 2010-07-05 2016-11-29 Merck Patent Gmbh derivados bipiridílicos úteis para o tratamento de doenças induzidas por quinases
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GB201312800D0 (en) 2013-07-17 2013-08-28 Heptares Therapeutics Ltd mGlu5 modulators
US20210305632A1 (en) 2020-03-25 2021-09-30 Gs Yuasa International Ltd. Energy storage device

Also Published As

Publication number Publication date
US20190177297A1 (en) 2019-06-13
CN108434147B (zh) 2021-02-02
US10584111B2 (en) 2020-03-10
CA2917450A1 (en) 2015-01-22
US20170275265A1 (en) 2017-09-28
US20200172505A1 (en) 2020-06-04
US10981889B2 (en) 2021-04-20
GB2532641A (en) 2016-05-25
US20220056009A1 (en) 2022-02-24
AU2018241104B2 (en) 2019-07-11
US9676745B2 (en) 2017-06-13
SG11201510738SA (en) 2016-01-28
AU2018241104A1 (en) 2018-10-25
AU2014291807A1 (en) 2016-01-28
GB201312800D0 (en) 2013-08-28
AU2014291807B2 (en) 2018-07-05
US20160145236A1 (en) 2016-05-26
WO2015008073A1 (en) 2015-01-22
BR112016001107B1 (pt) 2022-12-06
CN108434147A (zh) 2018-08-24
EP3022189B1 (en) 2018-09-26
BR112016001107A8 (pt) 2018-01-30
US11680053B2 (en) 2023-06-20
EP3022189A1 (en) 2016-05-25
US11584732B2 (en) 2023-02-21
US10246432B2 (en) 2019-04-02
JP6346666B2 (ja) 2018-06-20
JP2016525111A (ja) 2016-08-22
ES2699780T3 (es) 2019-02-12
US20240092754A1 (en) 2024-03-21
CA2917450C (en) 2021-06-29
GB201602618D0 (en) 2016-03-30
CN105377832A (zh) 2016-03-02
US20210309632A1 (en) 2021-10-07
CN105377832B (zh) 2018-05-04

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