SG11201510738SA - 4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 modulators - Google Patents
4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 modulatorsInfo
- Publication number
- SG11201510738SA SG11201510738SA SG11201510738SA SG11201510738SA SG11201510738SA SG 11201510738S A SG11201510738S A SG 11201510738SA SG 11201510738S A SG11201510738S A SG 11201510738SA SG 11201510738S A SG11201510738S A SG 11201510738SA SG 11201510738S A SG11201510738S A SG 11201510738SA
- Authority
- SG
- Singapore
- Prior art keywords
- pyridinylpyrimidine
- cyanophenyl
- mglu5
- modulators
- mglu5 modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1312800.4A GB201312800D0 (en) | 2013-07-17 | 2013-07-17 | mGlu5 modulators |
PCT/GB2014/052184 WO2015008073A1 (en) | 2013-07-17 | 2014-07-17 | 4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201510738SA true SG11201510738SA (en) | 2016-01-28 |
Family
ID=49081419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201510738SA SG11201510738SA (en) | 2013-07-17 | 2014-07-17 | 4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 modulators |
Country Status (11)
Country | Link |
---|---|
US (7) | US9676745B2 (pt) |
EP (1) | EP3022189B1 (pt) |
JP (1) | JP6346666B2 (pt) |
CN (2) | CN105377832B (pt) |
AU (2) | AU2014291807B2 (pt) |
BR (1) | BR112016001107B1 (pt) |
CA (1) | CA2917450C (pt) |
ES (1) | ES2699780T3 (pt) |
GB (2) | GB201312800D0 (pt) |
SG (1) | SG11201510738SA (pt) |
WO (1) | WO2015008073A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201312800D0 (en) * | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
WO2019072617A1 (en) | 2017-10-13 | 2019-04-18 | Cynora Gmbh | ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES |
WO2023249789A1 (en) * | 2022-06-24 | 2023-12-28 | Tempero Bio, Inc. | Methods of treating substance use disorder with 4-(3-cyanophenyl)-6-pyridinylpyrimidine mglu5 negative allosteric modulators |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100860827B1 (ko) * | 2000-09-06 | 2008-09-30 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 글리코겐 합성효소 키나아제 3의 억제제 |
AU2002359714B2 (en) * | 2001-12-18 | 2006-12-21 | Merck Sharp & Dohme Corp. | Heteroaryl substituted pyrazole modulators of metabotropic glutamate receptor-5 |
US7105548B2 (en) * | 2001-12-18 | 2006-09-12 | Merck & Co., Inc. | Heteroaryl substituted triazole modulators of metabotropic glutamate receptor-5 |
WO2004084824A2 (en) | 2003-03-24 | 2004-10-07 | Merck & Co., Inc. | Biaryl substituted 6-membered heterocyles as sodium channel blockers |
DE10315573A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
ES2303969T3 (es) | 2003-12-19 | 2008-09-01 | Astrazeneca Ab | 5-fluoro- y cloro-piridin-2-il-tetrazoles como ligandos del receptor metabotropico de glutamato de tipo 5. |
ATE402935T1 (de) * | 2004-02-18 | 2008-08-15 | Astrazeneca Ab | Kondensierte heterocyclische verbindungen und deren verwendung als antagonisten des metabotropen rezeptors zur behandlung von gastrointestinalen erkrankungen |
UA82435C2 (uk) * | 2004-02-18 | 2008-04-10 | Astrazeneca Ab | Конденсовані гетероциклічні сполуки та їх застосування як метаботропних антагоністів рецепторів глутамату, фармацевтична композиція на їх основі |
WO2009011850A2 (en) | 2007-07-16 | 2009-01-22 | Abbott Laboratories | Novel therapeutic compounds |
US8536186B2 (en) | 2008-08-04 | 2013-09-17 | Chdi Foundation, Inc. | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
MX2012008346A (es) | 2010-01-25 | 2012-11-12 | Chdi Foundation Inc | Determinados inhibidores de cinurenina-3-monooxigenasa, composiciones farmceuticas y metodos de uso de los mismos. |
BR112012033658A2 (pt) | 2010-07-05 | 2016-11-29 | Merck Patent Gmbh | derivados bipiridílicos úteis para o tratamento de doenças induzidas por quinases |
EP2548864B1 (en) | 2011-07-22 | 2014-02-19 | Université Joseph Fourier | Novel bis-indolic derivatives, a process for preparing the same and their uses as a drug |
GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
US20210305632A1 (en) | 2020-03-25 | 2021-09-30 | Gs Yuasa International Ltd. | Energy storage device |
-
2013
- 2013-07-17 GB GBGB1312800.4A patent/GB201312800D0/en not_active Ceased
-
2014
- 2014-07-17 CA CA2917450A patent/CA2917450C/en active Active
- 2014-07-17 US US14/904,907 patent/US9676745B2/en active Active
- 2014-07-17 ES ES14742326T patent/ES2699780T3/es active Active
- 2014-07-17 EP EP14742326.3A patent/EP3022189B1/en active Active
- 2014-07-17 SG SG11201510738SA patent/SG11201510738SA/en unknown
- 2014-07-17 JP JP2016526702A patent/JP6346666B2/ja active Active
- 2014-07-17 BR BR112016001107-4A patent/BR112016001107B1/pt active IP Right Grant
- 2014-07-17 GB GB1602618.9A patent/GB2532641A/en not_active Withdrawn
- 2014-07-17 WO PCT/GB2014/052184 patent/WO2015008073A1/en active Application Filing
- 2014-07-17 CN CN201480039925.5A patent/CN105377832B/zh active Active
- 2014-07-17 CN CN201810360220.3A patent/CN108434147B/zh active Active
- 2014-07-17 AU AU2014291807A patent/AU2014291807B2/en active Active
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2017
- 2017-06-09 US US15/618,504 patent/US10246432B2/en active Active
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2018
- 2018-10-04 AU AU2018241104A patent/AU2018241104B2/en active Active
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2019
- 2019-02-20 US US16/280,512 patent/US10584111B2/en active Active
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2020
- 2020-02-03 US US16/780,155 patent/US10981889B2/en active Active
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2021
- 2021-03-16 US US17/203,146 patent/US11584732B2/en active Active
- 2021-11-04 US US17/519,486 patent/US11680053B2/en active Active
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2023
- 2023-03-24 US US18/189,943 patent/US20240092754A1/en active Pending
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