BR112015024743A2 - composto de biarila substituída - Google Patents

composto de biarila substituída

Info

Publication number
BR112015024743A2
BR112015024743A2 BR112015024743A BR112015024743A BR112015024743A2 BR 112015024743 A2 BR112015024743 A2 BR 112015024743A2 BR 112015024743 A BR112015024743 A BR 112015024743A BR 112015024743 A BR112015024743 A BR 112015024743A BR 112015024743 A2 BR112015024743 A2 BR 112015024743A2
Authority
BR
Brazil
Prior art keywords
substituted biaryl
biaryl compound
compound
present
substituted
Prior art date
Application number
BR112015024743A
Other languages
English (en)
Inventor
Yoneda Kenji
Yamamoto Kiyoshi
Ito Koji
Shibakawa Nobuhiko
Iwase Noriaki
Ushiyama Shigeru
Katsube Tetsushi
Kanda Tomoko
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of BR112015024743A2 publication Critical patent/BR112015024743A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)

Abstract

resumo patente de invenção para: "composto de biarila substituída." a presente invenção fornece um composto de biarila substituída de fórmula geral (i) (em que, r1, w, r2, e z são como definidos nas reivindicações e descrição), ou um sal farmacologicamente aceitável do mesmo. o composto de acordo com a presente invenção tem um efeito de inibição excelente de proliferação de um fibroblasto pulmonar, e é, portanto, útil como um agente terapêutico e/ou um agente profilático para pneumonia intersticial e fibrose pulmonar.
BR112015024743A 2013-03-28 2014-03-28 composto de biarila substituída BR112015024743A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013069363 2013-03-28
JP2013228489 2013-11-01
PCT/JP2014/059301 WO2014157672A1 (ja) 2013-03-28 2014-03-28 置換ビアリール化合物

Publications (1)

Publication Number Publication Date
BR112015024743A2 true BR112015024743A2 (pt) 2017-07-18

Family

ID=51624629

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015024743A BR112015024743A2 (pt) 2013-03-28 2014-03-28 composto de biarila substituída

Country Status (15)

Country Link
US (1) US9676720B2 (pt)
EP (1) EP2980075A4 (pt)
JP (1) JPWO2014157672A1 (pt)
KR (1) KR20150135460A (pt)
CN (1) CN105308023A (pt)
AU (1) AU2014244926A1 (pt)
BR (1) BR112015024743A2 (pt)
CA (1) CA2908223A1 (pt)
HK (2) HK1219103A1 (pt)
MX (1) MX2015013848A (pt)
PH (1) PH12015502255A1 (pt)
RU (1) RU2015145989A (pt)
SG (1) SG11201507976YA (pt)
TW (1) TW201527282A (pt)
WO (1) WO2014157672A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10519112B2 (en) 2014-06-10 2019-12-31 Ube Industries, Ltd. Method for producing heteroaromatic sulfonamide compound
CA2951784C (en) * 2014-06-10 2022-05-31 Ube Industries, Ltd. N-substituted sulfonamide compound and method for producing same
US10774072B2 (en) 2014-06-10 2020-09-15 Ube Industries, Ltd. Crystal of N-substituted sulfonamide compound
JP2017206445A (ja) * 2014-09-26 2017-11-24 宇部興産株式会社 呼吸器疾患の治療及び／又は予防のための医薬組成物
JP2017206443A (ja) * 2014-09-26 2017-11-24 宇部興産株式会社 置換ビアリール化合物及び他の医薬の組み合わせ
CN108884047B (zh) * 2016-03-25 2022-03-08 沈阳三生制药有限责任公司 用于合成被芳基或杂芳基取代的5-羟基-1,7-萘啶化合物的中间体及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
UA67754C2 (uk) 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
US20020063763A1 (en) 2000-11-29 2002-05-30 Mantell David Allen Apparatus and method for removing air bubbles from an ink jet printhead
CA2401984A1 (en) 2000-03-22 2001-09-27 Merck Frosst Canada Inc. Sulfur substituted aryldifluoromethylphosphonic acids as ptp-1b inhibitors
AU2003211574A1 (en) 2002-03-05 2003-09-16 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
WO2004078169A1 (en) 2003-03-04 2004-09-16 Pfizer Products Inc. Use of ep2 selective receptor agonists in medical treatment
EP1723132A1 (en) 2004-02-12 2006-11-22 Asterand Uk Limited Ep2 receptor agonists
WO2006043655A1 (ja) 2004-10-22 2006-04-27 Ono Pharmaceutical Co., Ltd. 吸入用医薬組成物
CA2593439C (en) 2005-01-14 2014-02-25 F. Hoffmann-La Roche Ag Thiazole-4-carboxamide derivatives as mglur5 antagonists
CA2618486A1 (en) 2005-08-09 2007-02-15 Asterand Uk Limited Ep2 receptor agonists
JP4583500B2 (ja) 2006-07-28 2010-11-17 ファイザー・プロダクツ・インク Ｅｐ２作動薬
CN101495452B (zh) * 2006-07-28 2012-04-25 辉瑞产品公司 Ep2激动剂
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
JP2010524858A (ja) 2007-04-10 2010-07-22 エスジーエックス ファーマシューティカルズ、インコーポレイテッド 縮合環複素環キナーゼ調節因子
DK2264009T3 (en) * 2008-03-12 2019-04-15 Ube Industries PYRIDYLAMINE ACEDIC ACID COMPOUND
SI2415763T1 (sl) * 2009-03-30 2016-05-31 Ube Industries, Ltd. Farmacevtski sestavek za zdravljenje ali preprečevanje glavkoma
EP2476668B1 (en) 2009-09-11 2013-11-06 Ube Industries, Ltd. Aniline compounds
WO2011030873A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 ベンジル化合物
WO2011030865A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 置換ベンジル化合物
EP2476678A4 (en) 2009-09-11 2013-02-20 Ube Industries SUBSTITUTED CARBONYL COMPOUNDS
WO2011030872A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 スルホンアミド化合物
WO2011030871A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 Ｎ－置換ヘテロアリール化合物
CA2785668A1 (en) 2009-12-25 2011-06-30 Ube Industries, Ltd. Aminopyridine compound
TW201542525A (zh) * 2013-09-02 2015-11-16 Ube Industries 肺疾患的治療及／或預防用的醫藥組成物

Also Published As

Publication number Publication date
HK1220457A1 (zh) 2017-05-05
JPWO2014157672A1 (ja) 2017-02-16
PH12015502255A1 (en) 2016-02-01
CA2908223A1 (en) 2014-10-02
SG11201507976YA (en) 2015-10-29
WO2014157672A1 (ja) 2014-10-02
CN105308023A (zh) 2016-02-03
RU2015145989A (ru) 2017-05-16
US20160060221A1 (en) 2016-03-03
EP2980075A4 (en) 2016-08-10
EP2980075A1 (en) 2016-02-03
HK1219103A1 (zh) 2017-03-24
MX2015013848A (es) 2016-03-01
TW201527282A (zh) 2015-07-16
AU2014244926A1 (en) 2015-11-12
US9676720B2 (en) 2017-06-13
KR20150135460A (ko) 2015-12-02

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 5A ANUIDADE.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2507 DE 22-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B07E Notice of approval relating to section 229 industrial property law

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI