MX2015013848A - Compuesto de biarilo sustituido. - Google Patents

Compuesto de biarilo sustituido.

Info

Publication number
MX2015013848A
MX2015013848A MX2015013848A MX2015013848A MX2015013848A MX 2015013848 A MX2015013848 A MX 2015013848A MX 2015013848 A MX2015013848 A MX 2015013848A MX 2015013848 A MX2015013848 A MX 2015013848A MX 2015013848 A MX2015013848 A MX 2015013848A
Authority
MX
Mexico
Prior art keywords
substituted biaryl
biaryl compound
present
pulmonary
substituted
Prior art date
Application number
MX2015013848A
Other languages
English (en)
Inventor
Nobuhiko Shibakawa
Original Assignee
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ube Industries filed Critical Ube Industries
Publication of MX2015013848A publication Critical patent/MX2015013848A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)

Abstract

La presente invención proporciona un compuesto de biarilo sustituido de la fórmula general (I): (ver Fórmula) en donde, R1, W, R2, y Z son como se definieron en las reivindicaciones y la descripción, o una sal farmacológicamente aceptable del mismo; el compuesto de acuerdo con la presente invención tiene un excelente efecto de inhibición de proliferación de fibroblasto pulmonar, y por lo tanto es útil como un agente terapéutico y/o un agente profiláctico para la neumonía intersticial y fibrosis pulmonar.
MX2015013848A 2013-03-28 2014-03-28 Compuesto de biarilo sustituido. MX2015013848A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013069363 2013-03-28
JP2013228489 2013-11-01
PCT/JP2014/059301 WO2014157672A1 (ja) 2013-03-28 2014-03-28 置換ビアリール化合物

Publications (1)

Publication Number Publication Date
MX2015013848A true MX2015013848A (es) 2016-03-01

Family

ID=51624629

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015013848A MX2015013848A (es) 2013-03-28 2014-03-28 Compuesto de biarilo sustituido.

Country Status (15)

Country Link
US (1) US9676720B2 (es)
EP (1) EP2980075A4 (es)
JP (1) JPWO2014157672A1 (es)
KR (1) KR20150135460A (es)
CN (1) CN105308023A (es)
AU (1) AU2014244926A1 (es)
BR (1) BR112015024743A2 (es)
CA (1) CA2908223A1 (es)
HK (2) HK1219103A1 (es)
MX (1) MX2015013848A (es)
PH (1) PH12015502255A1 (es)
RU (1) RU2015145989A (es)
SG (1) SG11201507976YA (es)
TW (1) TW201527282A (es)
WO (1) WO2014157672A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10519112B2 (en) 2014-06-10 2019-12-31 Ube Industries, Ltd. Method for producing heteroaromatic sulfonamide compound
JP6572891B2 (ja) 2014-06-10 2019-09-11 宇部興産株式会社 Ｎ−置換スルホンアミド化合物およびその製造方法
US10774072B2 (en) 2014-06-10 2020-09-15 Ube Industries, Ltd. Crystal of N-substituted sulfonamide compound
JP2017206443A (ja) * 2014-09-26 2017-11-24 宇部興産株式会社 置換ビアリール化合物及び他の医薬の組み合わせ
JP2017206445A (ja) * 2014-09-26 2017-11-24 宇部興産株式会社 呼吸器疾患の治療及び／又は予防のための医薬組成物
CN108884047B (zh) * 2016-03-25 2022-03-08 沈阳三生制药有限责任公司 用于合成被芳基或杂芳基取代的5-羟基-1,7-萘啶化合物的中间体及其制备方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA59384C2 (uk) 1996-12-20 2003-09-15 Пфайзер, Інк. Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі
UA67754C2 (uk) 1997-10-10 2004-07-15 Пфайзер, Інк. Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти)
US20020063763A1 (en) 2000-11-29 2002-05-30 Mantell David Allen Apparatus and method for removing air bubbles from an ink jet printhead
US6498151B2 (en) 2000-03-22 2002-12-24 Merck Frosst Canada & Co. Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
US7402605B2 (en) 2002-03-05 2008-07-22 Ono Pharmaceutical Co., Ltd. 8-azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient
CA2518193A1 (en) 2003-03-04 2004-09-16 Pfizer Products Inc. Use of ep2 selective receptor agonists in medical treatment
US7326732B2 (en) 2004-02-12 2008-02-05 Pharmagene Laboratories Limited EP2 receptor agonists
EP1806148A4 (en) 2004-10-22 2009-12-02 Ono Pharmaceutical Co THERAPEUTIC PREPARATION FOR INHALATION
WO2006074884A1 (en) 2005-01-14 2006-07-20 F.Hoffmann-La Roche Ag Thiazole-4-carboxamide derivatives as mglur5 antagonists
JP2009505973A (ja) 2005-08-09 2009-02-12 アステランド ユーケイ リミテッド Ｅｐ２受容体アゴニスト
CN101495452B (zh) * 2006-07-28 2012-04-25 辉瑞产品公司 Ep2激动剂
RS20090002A (en) 2006-07-28 2010-06-30 Pfizer Products Inc. Ep2 agonists
WO2008065500A2 (en) 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
EP2078020A4 (en) 2007-04-10 2011-10-19 Sgx Pharmaceuticals Inc HETEROCYCLIC MODULATORS WITH FUSED CYCLES FOR KINASES
CN103965099A (zh) * 2008-03-12 2014-08-06 宇部兴产株式会社 吡啶基氨基乙酸化合物
DK2415763T3 (en) 2009-03-30 2016-03-07 Ube Industries A pharmaceutical composition for the treatment or prevention of glaucoma
WO2011030868A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 置換カルボニル化合物
WO2011030873A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 ベンジル化合物
WO2011030872A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 スルホンアミド化合物
CA2773997A1 (en) 2009-09-11 2011-03-17 Ube Industries, Ltd. Aniline compound
WO2011030871A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 Ｎ－置換ヘテロアリール化合物
WO2011030865A1 (ja) 2009-09-11 2011-03-17 宇部興産株式会社 置換ベンジル化合物
AU2010336248A1 (en) 2009-12-25 2012-08-02 Ube Industries, Ltd. Aminopyridine compound
EP3042656A1 (en) * 2013-09-02 2016-07-13 UBE Industries, Ltd. Pharmaceutical composition for treatment and/or prevention of pulmonary disease

Also Published As

Publication number Publication date
BR112015024743A2 (pt) 2017-07-18
US20160060221A1 (en) 2016-03-03
TW201527282A (zh) 2015-07-16
JPWO2014157672A1 (ja) 2017-02-16
SG11201507976YA (en) 2015-10-29
HK1220457A1 (zh) 2017-05-05
AU2014244926A1 (en) 2015-11-12
US9676720B2 (en) 2017-06-13
PH12015502255A1 (en) 2016-02-01
EP2980075A1 (en) 2016-02-03
RU2015145989A (ru) 2017-05-16
CN105308023A (zh) 2016-02-03
WO2014157672A1 (ja) 2014-10-02
KR20150135460A (ko) 2015-12-02
HK1219103A1 (zh) 2017-03-24
CA2908223A1 (en) 2014-10-02
EP2980075A4 (en) 2016-08-10

Similar Documents

Publication Publication Date Title
PH12015502255A1 (en) Substituted biaryl compound
PH12016502398A1 (en) Dihydropyrimido loop derivative as hbv inhibitor
PH12017500408A1 (en) Heteroaryl compunds as btk inhibitors and uses thereof
MX2018002986A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y sus usos.
MX2016005054A (es) Compuestos heteroarilo como inhibidores de tirosina cinasa de bruton (bkt) y usos de los mismos.
MX2016002794A (es) Compuestos antiproliferativos.
AU2015207757A8 (en) N-azaspirocycloalkane substituted n-heteroaryl compounds and compositions for inhibiting the activity of SHP2
NZ739676A (en) Heteroaryl compounds as irak inhibitors and uses thereof
PH12017502051A1 (en) TBK/IKKe INHIBITOR COMPOUNDS AND USES THEREOF
NZ715838A (en) Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
PH12015501843A1 (en) Novel pyrazol derivatives
MX2017013798A (es) Inhibidores jak.
EA024194B8 (ru) Содержащие диарилацетиленгидразид ингибиторы тирозинкиназы
MX2015003594A (es) Agente terapeutico o profilactico para sindrome de lisis tumoral.
MX2015017156A (es) Inhibidores de bace.
PH12015501933A1 (en) Novel pyridine derivatives
PH12015502118A1 (en) Pyridin-4-yl derivatives
PH12015502471A1 (en) Purine derivatives as cb2 receptor agonists
MX2017016619A (es) Derivados de pirimidina como inhibidores de tirosina cinasa de bruton (btk) y usos de los mismos.
MX2020006434A (es) Nuevos compuestos inhibidores del blanco mecanistico de rapamicina (mtor).
MY193239A (en) Novel b-lactamase inhibitors
IN2013MU03862A (es)
MX2020006436A (es) Compuestos inhibidores del blanco mecanistico de rapamicina (mtor).
MX2015016766A (es) Nuevos derivados de tetrazolona.
AU2013314244A8 (en) Novel inhibitor compounds of phosphodiesterase type 10A

Legal Events

Date Code Title Description
HH Correction or change in general