BR112015018895A2 - composição farmacêutica multiparticulada compreendendo uma multiplicidade de dois tipos de pelotas - Google Patents
composição farmacêutica multiparticulada compreendendo uma multiplicidade de dois tipos de pelotasInfo
- Publication number
- BR112015018895A2 BR112015018895A2 BR112015018895A BR112015018895A BR112015018895A2 BR 112015018895 A2 BR112015018895 A2 BR 112015018895A2 BR 112015018895 A BR112015018895 A BR 112015018895A BR 112015018895 A BR112015018895 A BR 112015018895A BR 112015018895 A2 BR112015018895 A2 BR 112015018895A2
- Authority
- BR
- Brazil
- Prior art keywords
- pellets
- types
- multiplicity
- pharmaceutical composition
- multiparticulate pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/009—Sachets, pouches characterised by the material or function of the envelope
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "composição farmacêutica multiparticulada compreendendo uma multiplicidade de dois tipos de pelotas". a presente invenção fornece composições farmacêuticas multiparticuladas compreendendo de dois tipos de pelotas, a e b, cada um compreendendo metoprolol ou um sal farmaceuticamente aceitável deste, como um ingrediente farmacêutico ativo, revestidas com diferentes camadas de revestimento, que apresentam um risco diminuído de "descarga de dose".
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN627CH2013 | 2013-02-13 | ||
PCT/EP2013/058625 WO2014124700A1 (en) | 2013-02-13 | 2013-04-25 | Multiparticulate pharmaceutical composition comprising a multitude of two kinds of pellets |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015018895A2 true BR112015018895A2 (pt) | 2017-07-18 |
Family
ID=54252463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015018895A BR112015018895A2 (pt) | 2013-02-13 | 2013-04-25 | composição farmacêutica multiparticulada compreendendo uma multiplicidade de dois tipos de pelotas |
Country Status (11)
Country | Link |
---|---|
US (1) | US20150366825A1 (pt) |
EP (1) | EP2956124A1 (pt) |
JP (1) | JP2016507576A (pt) |
KR (1) | KR20150119069A (pt) |
CN (1) | CN105007902A (pt) |
BR (1) | BR112015018895A2 (pt) |
CA (1) | CA2900781A1 (pt) |
IL (1) | IL240087A0 (pt) |
MX (1) | MX2015010449A (pt) |
RU (1) | RU2015138784A (pt) |
WO (1) | WO2014124700A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3801378A4 (en) | 2018-05-24 | 2022-02-23 | Celanese EVA Performance Polymers LLC | IMPLANTABLE DEVICE FOR THE DELAYED RELEASE OF A MACROMOLECULAR DRUG COMPOUND |
CA3087238A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
CN113747887A (zh) * | 2019-04-30 | 2021-12-03 | 赢创运营有限公司 | 微丸和多单元微丸系统(mups) |
CN113143877A (zh) * | 2021-05-07 | 2021-07-23 | 苏州康恒研新药物技术有限公司 | 一种琥珀酸美托洛尔微丸缓释片的制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE455836B (sv) | 1985-10-11 | 1988-08-15 | Haessle Ab | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
SE450087B (sv) | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
DE10011447A1 (de) | 2000-03-10 | 2001-09-20 | Roehm Gmbh | Dispersion mit nichtionischem Emulgator |
SE0100200D0 (sv) | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
HUP0303886A3 (en) | 2001-12-19 | 2005-05-30 | Astrazeneca Ab | New film coating composition for coating of pharmaceutical compositions |
SE0202353D0 (sv) | 2002-08-01 | 2002-08-01 | Astrazeneca Ab | New film coating |
US7314640B2 (en) * | 2003-07-11 | 2008-01-01 | Mongkol Sriwongjanya | Formulation and process for drug loaded cores |
DE102004011349A1 (de) | 2004-03-05 | 2005-09-22 | Basf Ag | Wässrige Polymerdispersion auf Basis von Alkyl(meth)-acrylaten |
BRPI0714586A2 (pt) | 2006-07-28 | 2013-05-07 | Farmaprojects S A | formulaÇço farmacÊutica de liberaÇço prolongada de metropolol e processo para a sua preparaÇço |
KR101454056B1 (ko) * | 2007-09-21 | 2014-10-27 | 에보니크 룀 게엠베하 | 에탄올의 영향에 대하여 내성을 가지는 비-오피오이드용 ph-의존성 조절 방출 제약 조성물 |
JP5619130B2 (ja) | 2009-03-18 | 2014-11-05 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツングEvonik RoehmGmbH | 中性ビニルポリマーおよび賦形剤を含むコーティングを使用するエタノールの影響に対する耐性を有する制御放出性医薬組成物 |
-
2013
- 2013-04-25 WO PCT/EP2013/058625 patent/WO2014124700A1/en active Application Filing
- 2013-04-25 RU RU2015138784A patent/RU2015138784A/ru unknown
- 2013-04-25 US US14/764,804 patent/US20150366825A1/en not_active Abandoned
- 2013-04-25 KR KR1020157024585A patent/KR20150119069A/ko not_active Application Discontinuation
- 2013-04-25 JP JP2015557339A patent/JP2016507576A/ja active Pending
- 2013-04-25 CA CA2900781A patent/CA2900781A1/en active Pending
- 2013-04-25 CN CN201380072949.6A patent/CN105007902A/zh active Pending
- 2013-04-25 EP EP13723428.2A patent/EP2956124A1/en not_active Withdrawn
- 2013-04-25 BR BR112015018895A patent/BR112015018895A2/pt not_active IP Right Cessation
- 2013-04-25 MX MX2015010449A patent/MX2015010449A/es unknown
-
2015
- 2015-07-22 IL IL240087A patent/IL240087A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20150366825A1 (en) | 2015-12-24 |
EP2956124A1 (en) | 2015-12-23 |
KR20150119069A (ko) | 2015-10-23 |
JP2016507576A (ja) | 2016-03-10 |
WO2014124700A1 (en) | 2014-08-21 |
IL240087A0 (en) | 2015-09-24 |
RU2015138784A (ru) | 2017-03-17 |
MX2015010449A (es) | 2015-10-30 |
CA2900781A1 (en) | 2014-08-21 |
CN105007902A (zh) | 2015-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |