BR112015014447B1 - Composição de cuidado oral, uso de ascorbil fosfato de zinco, uso da composição de cuidado oral, kit de cuidado oral e método de fabricação da referida composição oral - Google Patents
Composição de cuidado oral, uso de ascorbil fosfato de zinco, uso da composição de cuidado oral, kit de cuidado oral e método de fabricação da referida composição oral Download PDFInfo
- Publication number
- BR112015014447B1 BR112015014447B1 BR112015014447-0A BR112015014447A BR112015014447B1 BR 112015014447 B1 BR112015014447 B1 BR 112015014447B1 BR 112015014447 A BR112015014447 A BR 112015014447A BR 112015014447 B1 BR112015014447 B1 BR 112015014447B1
- Authority
- BR
- Brazil
- Prior art keywords
- zinc
- composition
- ascorbyl phosphate
- oral care
- agents
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 175
- 229910000165 zinc phosphate Inorganic materials 0.000 title claims description 10
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- LRXTYHSAJDENHV-UHFFFAOYSA-H zinc phosphate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LRXTYHSAJDENHV-UHFFFAOYSA-H 0.000 title description 3
- DBSABEYSGXPBTA-RXSVEWSESA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DBSABEYSGXPBTA-RXSVEWSESA-N 0.000 claims abstract description 93
- 229940071097 ascorbyl phosphate Drugs 0.000 claims abstract description 90
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 68
- 239000011701 zinc Substances 0.000 claims abstract description 67
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 60
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 25
- 239000004615 ingredient Substances 0.000 claims abstract description 23
- 201000010099 disease Diseases 0.000 claims abstract description 18
- 230000000845 anti-microbial effect Effects 0.000 claims abstract description 17
- 208000035475 disorder Diseases 0.000 claims abstract description 16
- 239000004599 antimicrobial Substances 0.000 claims abstract description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 58
- -1 mouthfeelers Substances 0.000 claims description 41
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- 239000011787 zinc oxide Substances 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 28
- 210000000214 mouth Anatomy 0.000 claims description 18
- 239000000725 suspension Substances 0.000 claims description 13
- 239000011230 binding agent Substances 0.000 claims description 12
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 11
- 239000006260 foam Substances 0.000 claims description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 10
- 239000000975 dye Substances 0.000 claims description 10
- 239000002324 mouth wash Substances 0.000 claims description 10
- 229940051866 mouthwash Drugs 0.000 claims description 10
- 239000003906 humectant Substances 0.000 claims description 9
- 239000002562 thickening agent Substances 0.000 claims description 9
- 239000000606 toothpaste Substances 0.000 claims description 9
- 229940034610 toothpaste Drugs 0.000 claims description 9
- 208000006558 Dental Calculus Diseases 0.000 claims description 8
- 239000008135 aqueous vehicle Substances 0.000 claims description 7
- 235000003599 food sweetener Nutrition 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- 239000003765 sweetening agent Substances 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 6
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- 238000002360 preparation method Methods 0.000 claims description 6
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- 230000002265 prevention Effects 0.000 claims description 3
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- 230000001070 adhesive effect Effects 0.000 claims description 2
- 238000004061 bleaching Methods 0.000 claims description 2
- 239000000796 flavoring agent Substances 0.000 claims description 2
- 238000000586 desensitisation Methods 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 239000008365 aqueous carrier Substances 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 13
- 239000000463 material Substances 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 11
- 150000003752 zinc compounds Chemical class 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 150000003839 salts Chemical class 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 7
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- 244000005700 microbiome Species 0.000 description 6
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- 239000000377 silicon dioxide Substances 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 239000007844 bleaching agent Substances 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 239000003975 dentin desensitizing agent Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 230000001464 adherent effect Effects 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000000551 dentifrice Substances 0.000 description 4
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- 235000011187 glycerol Nutrition 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 239000011775 sodium fluoride Substances 0.000 description 4
- 235000013024 sodium fluoride Nutrition 0.000 description 4
- 229960000414 sodium fluoride Drugs 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 235000010356 sorbitol Nutrition 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 229960002920 sorbitol Drugs 0.000 description 4
- 239000011592 zinc chloride Substances 0.000 description 4
- 235000005074 zinc chloride Nutrition 0.000 description 4
- DDKJKQVNNATMAD-JEDNCBNOSA-N (2s)-2,6-diaminohexanoic acid;zinc Chemical compound [Zn].NCCCC[C@H](N)C(O)=O DDKJKQVNNATMAD-JEDNCBNOSA-N 0.000 description 3
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- 206010020751 Hypersensitivity Diseases 0.000 description 3
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000004974 alkaline earth metal peroxides Chemical class 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 239000006184 cosolvent Substances 0.000 description 3
- 208000002925 dental caries Diseases 0.000 description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 3
- 230000009610 hypersensitivity Effects 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 238000004811 liquid chromatography Methods 0.000 description 3
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 3
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- RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
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- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 150000004965 peroxy acids Chemical class 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000002694 phosphate binding agent Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229940094025 potassium bicarbonate Drugs 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 229940093928 potassium nitrate Drugs 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000013464 silicone adhesive Substances 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- UKLNMMHNWFDKNT-UHFFFAOYSA-M sodium chlorite Chemical compound [Na+].[O-]Cl=O UKLNMMHNWFDKNT-UHFFFAOYSA-M 0.000 description 1
- 229960002218 sodium chlorite Drugs 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
- DOJOZCIMYABYPO-UHFFFAOYSA-M sodium;3,4-dihydroxy-4-oxobutanoate Chemical compound [Na+].OC(=O)C(O)CC([O-])=O DOJOZCIMYABYPO-UHFFFAOYSA-M 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/58—Metal complex; Coordination compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2012/070497 WO2014098817A1 (en) | 2012-12-19 | 2012-12-19 | Oral care composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015014447A2 BR112015014447A2 (pt) | 2017-07-11 |
| BR112015014447B1 true BR112015014447B1 (pt) | 2019-07-09 |
Family
ID=47501516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015014447-0A BR112015014447B1 (pt) | 2012-12-19 | 2012-12-19 | Composição de cuidado oral, uso de ascorbil fosfato de zinco, uso da composição de cuidado oral, kit de cuidado oral e método de fabricação da referida composição oral |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9757320B2 (enExample) |
| EP (1) | EP2934440B1 (enExample) |
| JP (1) | JP2016503790A (enExample) |
| KR (1) | KR20150097495A (enExample) |
| CN (1) | CN104853719B (enExample) |
| AR (1) | AR094196A1 (enExample) |
| AU (1) | AU2012397258B2 (enExample) |
| BR (1) | BR112015014447B1 (enExample) |
| CA (1) | CA2892408C (enExample) |
| IL (1) | IL239422A0 (enExample) |
| MX (1) | MX352313B (enExample) |
| PH (1) | PH12015501237A1 (enExample) |
| RU (1) | RU2636218C2 (enExample) |
| TW (1) | TWI532503B (enExample) |
| WO (1) | WO2014098817A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12151007B2 (en) | 2020-06-26 | 2024-11-26 | Colgate-Palmolive Company | Electrochemical tooth whitening composition and method thereof |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63141921A (ja) | 1986-12-04 | 1988-06-14 | Kao Corp | 口腔用組成物 |
| US5059416A (en) | 1989-06-26 | 1991-10-22 | Warner-Lambert Company | Zinc compound delivery system with improved taste and texture |
| JP3772468B2 (ja) | 1997-06-11 | 2006-05-10 | 昭和電工株式会社 | Ｌ−アスコルビン酸−２−リン酸亜鉛塩及びその製造方法 |
| US6420419B1 (en) * | 1997-11-06 | 2002-07-16 | Showa Denko Kabushiki Kaisha | L-ascorbic acid 2-phosphate zinc salt and process for manufacturing the same |
| JP2000351905A (ja) | 1999-04-05 | 2000-12-19 | Showa Denko Kk | アスコルビン酸誘導体含有組成物 |
| US20020137728A1 (en) * | 2001-01-24 | 2002-09-26 | Oraceutical Llc | Topical oral care compositions |
| BR0209455A (pt) | 2001-05-10 | 2004-07-06 | Roche Vitamins Ag | Dentifrìcio |
| AU2003267393A1 (en) | 2002-11-04 | 2004-06-07 | Dsm Ip Assets B.V. | Oral care compositions comprising ascorbic acid derivative |
| CN1805692B (zh) | 2003-06-16 | 2010-10-27 | 帝斯曼知识产权资产管理有限公司 | 宠物食品组合物 |
| CA2535219A1 (en) * | 2003-09-09 | 2005-03-24 | Dsm Ip Assets B.V. | Orally effective, essentially water-free topical agent containing one or several oxidation-sensitive substances |
| US20050271602A1 (en) | 2004-06-02 | 2005-12-08 | Nebojsa Milanovich | Method for inhibiting chemical staining of teeth |
| US8916050B2 (en) * | 2004-09-27 | 2014-12-23 | Special Water Patents B.V. | Methods and compositions for treatment of water |
| US8337818B2 (en) | 2004-11-03 | 2012-12-25 | Colgate-Palmolive Company | Post-foaming dental mousse and methods utilizing the same |
| EP1698324A1 (en) | 2004-11-09 | 2006-09-06 | The Procter & Gamble Company | Zinc-containing dentifrice compositions having an improved taste |
| US8858920B2 (en) | 2004-12-21 | 2014-10-14 | Colgate-Palmolive Company | Anti-caries oral care composition with xylitol |
| US8758838B2 (en) | 2005-08-31 | 2014-06-24 | Johnson & Johnson Consumer Companies, Inc. | Anti-inflammatory compositions and methods of use |
| EP3871693A1 (en) | 2005-09-27 | 2021-09-01 | Special Water Patents B.V. | Compositions for oral care |
| SG169990A1 (en) | 2005-12-21 | 2011-04-29 | Colgate Palmolive Co | Improved oral compositions comprising zinc citrate and/or tocopherol agents |
| US20110280855A1 (en) | 2006-10-23 | 2011-11-17 | Neil Levin | Vitamin c compositions |
| WO2010074025A1 (ja) | 2008-12-24 | 2010-07-01 | ライオン株式会社 | 歯磨剤組成物 |
| BRPI0924882A2 (pt) | 2009-04-01 | 2015-07-07 | Colgate Palmolive Co | Composição para cuidado oral, e, uso de pelo menos um composto de carbonato e pelo menos um excipiente |
| TW201109022A (en) | 2009-06-03 | 2011-03-16 | Colgate Palmolive Co | Borinic compositions |
| AU2011227198A1 (en) | 2010-03-17 | 2012-10-04 | Arbonne International Llc | Topical skin care composition |
| EP2555829B1 (en) | 2010-04-09 | 2016-11-02 | Unilever PLC | Oral care compositions |
| BR112013010519A2 (pt) | 2010-10-27 | 2016-07-05 | Colgate Palmolive Co | composição de higiene oral compreendendo arginina e carbonato de cálcio |
| JP5716388B2 (ja) | 2010-12-24 | 2015-05-13 | ライオン株式会社 | 歯磨剤組成物及び歯磨剤組成物におけるアスコルビン酸リン酸エステル又はその塩の安定化方法 |
| PH12013501964A1 (en) | 2011-04-04 | 2013-11-25 | Unilever Ip Holdings B V | Oral care compositions |
-
2012
- 2012-12-19 CN CN201280077846.4A patent/CN104853719B/zh active Active
- 2012-12-19 RU RU2015129108A patent/RU2636218C2/ru active
- 2012-12-19 US US14/652,780 patent/US9757320B2/en active Active
- 2012-12-19 WO PCT/US2012/070497 patent/WO2014098817A1/en not_active Ceased
- 2012-12-19 CA CA2892408A patent/CA2892408C/en active Active
- 2012-12-19 JP JP2015549325A patent/JP2016503790A/ja active Pending
- 2012-12-19 EP EP12809988.4A patent/EP2934440B1/en active Active
- 2012-12-19 BR BR112015014447-0A patent/BR112015014447B1/pt active IP Right Grant
- 2012-12-19 MX MX2015007677A patent/MX352313B/es active IP Right Grant
- 2012-12-19 AU AU2012397258A patent/AU2012397258B2/en active Active
- 2012-12-19 KR KR1020157015478A patent/KR20150097495A/ko not_active Withdrawn
-
2013
- 2013-12-05 TW TW102144527A patent/TWI532503B/zh not_active IP Right Cessation
- 2013-12-19 AR ARP130104929A patent/AR094196A1/es unknown
-
2015
- 2015-06-02 PH PH12015501237A patent/PH12015501237A1/en unknown
- 2015-06-15 IL IL239422A patent/IL239422A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR094196A1 (es) | 2015-07-15 |
| US20160008254A1 (en) | 2016-01-14 |
| KR20150097495A (ko) | 2015-08-26 |
| PH12015501237A1 (en) | 2015-08-17 |
| BR112015014447A2 (pt) | 2017-07-11 |
| MX2015007677A (es) | 2015-09-07 |
| CA2892408A1 (en) | 2014-06-26 |
| EP2934440A1 (en) | 2015-10-28 |
| JP2016503790A (ja) | 2016-02-08 |
| TW201438750A (zh) | 2014-10-16 |
| WO2014098817A1 (en) | 2014-06-26 |
| AU2012397258B2 (en) | 2015-10-01 |
| MX352313B (es) | 2017-11-17 |
| TWI532503B (zh) | 2016-05-11 |
| AU2012397258A1 (en) | 2015-06-11 |
| RU2636218C2 (ru) | 2017-11-21 |
| RU2015129108A (ru) | 2017-01-25 |
| IL239422A0 (en) | 2015-07-30 |
| CN104853719A (zh) | 2015-08-19 |
| EP2934440B1 (en) | 2018-02-21 |
| US9757320B2 (en) | 2017-09-12 |
| CN104853719B (zh) | 2017-11-03 |
| CA2892408C (en) | 2019-10-08 |
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