BR112015003715A8 - análise de raman, de infravermelho, ou de raman-infravermelho da estrutura de proteína de plasma de sangue periférico e sua relação para desenvolvimento cognitivo no mal de alzheimer - Google Patents
análise de raman, de infravermelho, ou de raman-infravermelho da estrutura de proteína de plasma de sangue periférico e sua relação para desenvolvimento cognitivo no mal de alzheimer Download PDFInfo
- Publication number
- BR112015003715A8 BR112015003715A8 BR112015003715A BR112015003715A BR112015003715A8 BR 112015003715 A8 BR112015003715 A8 BR 112015003715A8 BR 112015003715 A BR112015003715 A BR 112015003715A BR 112015003715 A BR112015003715 A BR 112015003715A BR 112015003715 A8 BR112015003715 A8 BR 112015003715A8
- Authority
- BR
- Brazil
- Prior art keywords
- raman
- infrared
- alzheimer
- disease
- analysis
- Prior art date
Links
- 238000001069 Raman spectroscopy Methods 0.000 title abstract 7
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 4
- 102000004506 Blood Proteins Human genes 0.000 title abstract 2
- 108010017384 Blood Proteins Proteins 0.000 title abstract 2
- 238000004458 analytical method Methods 0.000 title abstract 2
- 230000008133 cognitive development Effects 0.000 title abstract 2
- 210000005259 peripheral blood Anatomy 0.000 title abstract 2
- 239000011886 peripheral blood Substances 0.000 title abstract 2
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000003595 spectral effect Effects 0.000 abstract 3
- 238000001237 Raman spectrum Methods 0.000 abstract 2
- 238000002329 infrared spectrum Methods 0.000 abstract 2
- 210000002381 plasma Anatomy 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 238000004566 IR spectroscopy Methods 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000012844 infrared spectroscopy analysis Methods 0.000 abstract 1
- 238000004611 spectroscopical analysis Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/061—Sources
- G01N2201/06113—Coherent sources; lasers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
análise de raman, de infravermelho, ou de ramaninfravermelho da estrutura de proteína de plasma de sangue periférico e sua relação para desenvolvimento cognitivo no mal de alzheimer a presente invenção refere-se a um método de espectroscopia de raman para a determinação da estrutura da proteína associada com a deterioração cognitiva global no mal de alzheimer a partir da análise espectroscópica de raman de uma amostra de sangue humano, de preferência de uma amostra de plasma de sangue humano, que compreende a obtenção de pelo menos um valor espectral de pelo menos uma das regiões do espectro de raman compreendida entre 1600 1700 cm-1, entre 910980 cm-1, entre 730760 cm-1 e / ou entre 390450 cm-1, e onde o dito valor espectral permite a obtenção de uma indicação da presença ou ausência da estrutura de proteína associada com uma condição do mal de alzheimer. a presente invenção também se refere a um método para a análise da espectroscopia de infravermelho de uma amostra de sangue, por meio da obtenção adicional de pelo menos um valor espectral de pelo menos uma das regiões do espectro de infravermelho que fica compreendida entre 1600 e 1700 cm-1, e / ou entre 1000 e 1150 cm-1 e / ou entre 1140 e 1190 cm-1. opcionalmente, o método de espectroscopia de raman compreende ainda a análise de espectroscopia de infravermelho da mesma amostra de sangue. a invenção também se refere a um método de diagnóstico para diagnosticar a mal de alzheimer que compreende medir um espectro de raman e / ou um espectro de infravermelho de uma amostra de plasma.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382330.4A EP2700933A1 (en) | 2012-08-20 | 2012-08-20 | Raman, infrared, or Raman-Infrared analysis of peripheral blood plasma protein structure and its relation to cognitive development in Alzheimer's disease |
| PCT/EP2013/067304 WO2014029767A1 (en) | 2012-08-20 | 2013-08-20 | Raman, infrared, or raman-infrared analysis of peripheral blood plasma protein structure and its relation to cognitive development in alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015003715A2 BR112015003715A2 (pt) | 2017-07-04 |
| BR112015003715A8 true BR112015003715A8 (pt) | 2019-08-06 |
Family
ID=47022606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015003715A BR112015003715A8 (pt) | 2012-08-20 | 2013-08-20 | análise de raman, de infravermelho, ou de raman-infravermelho da estrutura de proteína de plasma de sangue periférico e sua relação para desenvolvimento cognitivo no mal de alzheimer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20150211988A1 (pt) |
| EP (2) | EP2700933A1 (pt) |
| JP (1) | JP2015531069A (pt) |
| CN (1) | CN104813159A (pt) |
| AU (1) | AU2013305058B2 (pt) |
| BR (1) | BR112015003715A8 (pt) |
| CA (1) | CA2882673A1 (pt) |
| HK (1) | HK1212433A1 (pt) |
| IL (1) | IL237358A0 (pt) |
| NZ (1) | NZ706107A (pt) |
| RU (1) | RU2015109714A (pt) |
| WO (1) | WO2014029767A1 (pt) |
| ZA (1) | ZA201501938B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9891108B2 (en) | 2012-10-03 | 2018-02-13 | The Research Foundation For The State University Of New York | Spectroscopic method for Alzheimer's disease diagnosis |
| WO2015009970A1 (en) | 2013-07-18 | 2015-01-22 | Erythron Llc | Spectroscopic measurements with parallel array detector |
| US11073470B2 (en) | 2014-02-14 | 2021-07-27 | Betasense Gmbh | Attenuated total reflectance-based biosensor for conformation and secondary structure analysis |
| WO2015131151A2 (en) | 2014-02-28 | 2015-09-03 | Erythron, Llc | Method and apparatus for determining markers of health by analysis of blood |
| DE102014014414B4 (de) * | 2014-09-29 | 2024-08-01 | Leibniz-Institut für Photonische Technologien e. V. | Verfahren und Anordnung zur Wasserstoff- Sensorik |
| WO2016168090A1 (en) * | 2015-04-14 | 2016-10-20 | Nueon, Inc. | Method and apparatus for determining markers of health by analysis of blood |
| WO2017165403A1 (en) | 2016-03-21 | 2017-09-28 | Nueon Inc. | Porous mesh spectrometry methods and apparatus |
| EP3249388A1 (en) * | 2016-05-23 | 2017-11-29 | Raman Health Technologies, S.L | Method for diagnosing alzheimer´s disease |
| WO2018085699A1 (en) | 2016-11-04 | 2018-05-11 | Nueon Inc. | Combination blood lancet and analyzer |
| EP3324186B1 (en) | 2016-11-21 | 2020-09-16 | Ruhr-Universität Bochum | Method for the preselection of drugs for protein misfolding diseases |
| ES2791962T3 (es) * | 2016-11-21 | 2020-11-06 | Univ Ruhr Bochum | Ensayo combinado para el diagnóstico diferencial de la enfermedad de Alzheimer |
| WO2018178474A2 (es) * | 2017-03-31 | 2018-10-04 | Consejo Superior De Investigaciones Científicas | Método de diagnóstico de demencia frontotemporal y enfermedad de alzheimer |
| CN107233347A (zh) * | 2017-06-07 | 2017-10-10 | 新乡医学院 | 一种治疗阿尔海默式综合症的药物组合物及其应用 |
| RU2668526C1 (ru) * | 2017-08-18 | 2018-10-01 | Федеральное государственное бюджетное учреждение "Информационно-методический центр по экспертизе, учету и анализу обращения средств медицинского применения" Федеральной службы по надзору в сфере здравоохранения | Способ идентификации и последующего количественного определения основных компонентов в инъекционных лекарственных средствах |
| GB201809403D0 (en) * | 2018-06-07 | 2018-07-25 | Univ Strathclyde | Method |
| CN109406487B (zh) * | 2018-10-29 | 2020-12-01 | 济南大学 | 检测阿尔茨海默症标志物的拉曼生物传感器及其制备方法 |
| EP4022287A1 (en) | 2019-08-28 | 2022-07-06 | Ventana Medical Systems, Inc. | Systems and methods for assessing specimen fixation duration and quality using vibrational spectroscopy |
| EP4415607A1 (en) * | 2021-10-15 | 2024-08-21 | The Trustees Of Indiana University | Methods for detecting fracture-related infection (fri) |
| CN114137122A (zh) * | 2021-12-01 | 2022-03-04 | 青岛海关技术中心 | 一种海关查验现场快速鉴定全蔗糖浆成分含量的方法 |
| CN114441502B (zh) * | 2022-01-21 | 2023-11-03 | 天津医科大学总医院 | 基于拉曼光谱和生物信息学分析技术鉴定海马神经元衰老的方法和试剂盒 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2435572C (en) * | 2001-01-22 | 2012-01-10 | Andreas Wolf | Rapid test for biological substances using ftir |
| DE102004061064A1 (de) * | 2004-12-18 | 2006-06-29 | Roche Diagnostics Gmbh | Verfahren und Vorrichtung zur spektroskopischen Untersuchung von Körperflüssigkeiten und Gewebeproben hinsichtlich eines erhöhten Alzheimerverdachts |
| EP1853894A1 (en) * | 2005-02-22 | 2007-11-14 | McGill University | Oxidative stress measurement device and related methods |
| CN101692094A (zh) * | 2009-08-18 | 2010-04-07 | 刘维甲 | 一种物质分析方法和仪器系统 |
| ES2358661B2 (es) * | 2009-10-28 | 2011-09-08 | Universidad De Santiago De Compostela | Utilización del gambierol para el tratamiento y/o la prevención de enfermedades neurodegenerativas relacionadas con tau y beta-amiloide. |
| CN101806740B (zh) * | 2010-04-19 | 2011-12-21 | 福建师范大学 | 一种人体血浆表面增强拉曼光谱结合主成分分析检测方法 |
| JP5672058B2 (ja) * | 2010-07-02 | 2015-02-18 | ソニー株式会社 | スペクトルデータ解析装置、生体内物質検出システム及び生体内物質検出方法 |
| CN102627605B (zh) * | 2012-03-22 | 2014-09-10 | 中国科学院上海药物研究所 | 石杉碱甲多晶型体、其制备方法、包含所述多晶型体的药物组合物及其用途 |
-
2012
- 2012-08-20 EP EP12382330.4A patent/EP2700933A1/en not_active Withdrawn
-
2013
- 2013-08-20 JP JP2015527892A patent/JP2015531069A/ja active Pending
- 2013-08-20 AU AU2013305058A patent/AU2013305058B2/en not_active Ceased
- 2013-08-20 RU RU2015109714A patent/RU2015109714A/ru not_active Application Discontinuation
- 2013-08-20 WO PCT/EP2013/067304 patent/WO2014029767A1/en active Application Filing
- 2013-08-20 CN CN201380054416.5A patent/CN104813159A/zh active Pending
- 2013-08-20 NZ NZ706107A patent/NZ706107A/en not_active IP Right Cessation
- 2013-08-20 BR BR112015003715A patent/BR112015003715A8/pt not_active Application Discontinuation
- 2013-08-20 CA CA2882673A patent/CA2882673A1/en not_active Abandoned
- 2013-08-20 EP EP13756001.7A patent/EP2885625A1/en not_active Withdrawn
- 2013-08-20 US US14/423,054 patent/US20150211988A1/en not_active Abandoned
-
2015
- 2015-02-22 IL IL237358A patent/IL237358A0/en unknown
- 2015-03-20 ZA ZA2015/01938A patent/ZA201501938B/en unknown
- 2015-12-22 HK HK15112591.1A patent/HK1212433A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1212433A1 (en) | 2016-06-10 |
| EP2885625A1 (en) | 2015-06-24 |
| AU2013305058B2 (en) | 2017-10-26 |
| ZA201501938B (en) | 2016-10-26 |
| EP2700933A1 (en) | 2014-02-26 |
| NZ706107A (en) | 2018-01-26 |
| RU2015109714A (ru) | 2016-10-10 |
| US20150211988A1 (en) | 2015-07-30 |
| JP2015531069A (ja) | 2015-10-29 |
| AU2013305058A8 (en) | 2015-06-11 |
| CN104813159A (zh) | 2015-07-29 |
| AU2013305058A1 (en) | 2015-04-09 |
| IL237358A0 (en) | 2015-04-30 |
| BR112015003715A2 (pt) | 2017-07-04 |
| WO2014029767A1 (en) | 2014-02-27 |
| CA2882673A1 (en) | 2014-02-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015003715A8 (pt) | análise de raman, de infravermelho, ou de raman-infravermelho da estrutura de proteína de plasma de sangue periférico e sua relação para desenvolvimento cognitivo no mal de alzheimer | |
| IN2014MN02060A (pt) | ||
| WO2006116637A3 (en) | Raman spectroscopy for non-invasive glucose measurements | |
| BR112013010015A2 (pt) | aparelho e método para detecção não invasiva de doenças que afetam as propriedades estruturais em tecidos biológicos | |
| WO2009090553A3 (en) | Compositions and methods of detecting post-stop peptides | |
| WO2010083204A3 (en) | Noninvasive measurement of flavonoid compounds in biological tissue | |
| MY184498A (en) | Methods for the diagnosis of ovarian cancer health states and risk of ovarian cancer health states | |
| TN2015000161A1 (en) | Methylglyoxal as a marker of cancer | |
| WO2006127861A3 (en) | Diagnosis of diseases and conditions by analysis of histopathologically processed biological samples using liquid tissue preparations | |
| AR095363A1 (es) | Biomarcadores y métodos para el tratamiento de condiciones relacionadas con pd-1 y pd-l1 | |
| WO2009131655A3 (en) | Automated assessment of optic nerve head with spectral domain optical coherence tomograph | |
| EP2660584A3 (en) | Method and apparatus for quantifying solutions comprised of multiple analytes | |
| WO2012018535A3 (en) | Wellness panel | |
| WO2015006489A8 (en) | Blood-based screen for detecting neurological diseases in primary care settings | |
| EA201590686A1 (ru) | Тест на митохондриальную токсичность | |
| EP2579043A4 (en) | DETECTION METHOD | |
| WO2015131151A2 (en) | Method and apparatus for determining markers of health by analysis of blood | |
| RU2013105265A (ru) | Способ диагностики рака поджелудочной железы | |
| EP2573192A4 (en) | METHOD AND KIT FOR DIAGNOSING DISEASE ASSOCIATED WITH AIM | |
| Stewart et al. | Cheek cell–derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control | |
| WO2013181418A3 (en) | Multiplexed diagnosis method for classical hodgkin lymphoma | |
| WO2008117027A3 (en) | Altered mitochondrial activity in diseases resulting from oxidative stress | |
| AR071034A1 (es) | Uso de la catepsina c en el diagnostico de susceptibilidad al dolor y para el tratamiento del dolor | |
| BR112015014232A2 (pt) | lesão renal aguda | |
| ES2570609T3 (es) | Método para someter a ensayo la aminoacilasa 1 para el diagnóstico in vitro del cáncer colorrectal |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |