BR112015000561A2 - inibidores de irak e usos dos mesmos - Google Patents
inibidores de irak e usos dos mesmosInfo
- Publication number
- BR112015000561A2 BR112015000561A2 BR112015000561A BR112015000561A BR112015000561A2 BR 112015000561 A2 BR112015000561 A2 BR 112015000561A2 BR 112015000561 A BR112015000561 A BR 112015000561A BR 112015000561 A BR112015000561 A BR 112015000561A BR 112015000561 A2 BR112015000561 A2 BR 112015000561A2
- Authority
- BR
- Brazil
- Prior art keywords
- irak inhibitors
- irak
- inhibitors
- compositions
- methods
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261670380P | 2012-07-11 | 2012-07-11 | |
| US201261682622P | 2012-08-13 | 2012-08-13 | |
| PCT/US2013/050113 WO2014011906A2 (en) | 2012-07-11 | 2013-07-11 | Irak inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015000561A2 true BR112015000561A2 (pt) | 2017-06-27 |
Family
ID=49914493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015000561A BR112015000561A2 (pt) | 2012-07-11 | 2013-07-11 | inibidores de irak e usos dos mesmos |
Country Status (10)
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012097013A1 (en) | 2011-01-10 | 2012-07-19 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| TWI589579B (zh) | 2012-01-10 | 2017-07-01 | 林伯士艾瑞斯公司 | Ｉｒａｋ抑制劑及其用途 |
| IN2015DN00127A (US07846941-20101207-C00154.png) | 2012-07-11 | 2015-05-29 | Nimbus Iris Inc | |
| US9085586B2 (en) | 2012-07-11 | 2015-07-21 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| US9175007B2 (en) | 2013-01-10 | 2015-11-03 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| EP2970196B1 (en) | 2013-03-15 | 2020-11-25 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
| BR112016006319A2 (pt) | 2013-09-27 | 2017-08-01 | Nimbus Iris Inc | inibidores de irak e usos dos mesmos |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| AR102849A1 (es) * | 2015-03-09 | 2017-03-29 | Astellas Pharma Inc | Compuesto de piridina bicíclica |
| BR112018003331B1 (pt) | 2015-08-28 | 2022-05-10 | Chdi Foundation, Inc | Agente de imagiologia, composto, seu uso e composição farmacêutica |
| JOP20180011A1 (ar) | 2017-02-16 | 2019-01-30 | Gilead Sciences Inc | مشتقات بيرولو [1، 2-b]بيريدازين |
| US11358948B2 (en) | 2017-09-22 | 2022-06-14 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| US11623932B2 (en) | 2017-09-22 | 2023-04-11 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| JP2021508703A (ja) | 2017-12-26 | 2021-03-11 | カイメラ セラピューティクス， インコーポレイテッド | Ｉｒａｋ分解剤およびそれらの使用 |
| EP3737666A4 (en) | 2018-01-12 | 2022-01-05 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
| US11512080B2 (en) | 2018-01-12 | 2022-11-29 | Kymera Therapeutics, Inc. | CRBN ligands and uses thereof |
| US11292792B2 (en) | 2018-07-06 | 2022-04-05 | Kymera Therapeutics, Inc. | Tricyclic CRBN ligands and uses thereof |
| TW202136268A (zh) | 2018-07-13 | 2021-10-01 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| MX2021006154A (es) | 2018-11-30 | 2021-08-24 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. |
| EP4076524A4 (en) | 2019-12-17 | 2023-11-29 | Kymera Therapeutics, Inc. | IRAQ DEGRADERS AND USES THEREOF |
| AU2020407200A1 (en) | 2019-12-17 | 2022-07-21 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1167367A4 (en) | 1999-03-30 | 2002-04-24 | Nippon Soda Co | THIENOPYRIMIDINE COMPOUNDS AND SALTS THEREOF, AND PROCESS FOR THE PREPARATION THEREOF |
| US6849638B2 (en) | 2001-04-30 | 2005-02-01 | Bayer Pharmaceuticals Corporation | 4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions |
| WO2003057149A2 (en) | 2001-12-28 | 2003-07-17 | Bayer Corporation | 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones |
| US20030225098A1 (en) | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| AU2003270701B2 (en) | 2002-10-31 | 2009-11-12 | Amgen Inc. | Antiinflammation agents |
| US7598259B2 (en) * | 2004-06-15 | 2009-10-06 | Schering Corporation | mGluR1 antagonists as therapeutic agents |
| AR049300A1 (es) * | 2004-06-15 | 2006-07-12 | Schering Corp | Compuestos triciclicos antagonistas de mglur1 como agentes terapeuticos |
| EP1619196A1 (de) * | 2004-07-23 | 2006-01-25 | Curacyte Discovery GmbH | Substituierte Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine und Pyrido[3',2':4,5]furo[3,2-d]-pyrimidine zur Verwendung als Inhibitoren der PDA-4 und/oder TNF-alpha Freisetzung |
| ATE455777T1 (de) * | 2004-07-23 | 2010-02-15 | Medicines Co Leipzig Gmbh | Substituierte pyridoä3',2':4,5üthienoä3,2- düpyrimidine und pyridoä3',2':4,5üfuroä3,2-dü- pyrimidine zur verwendung als inhibitoren der pda-4 und/oder tnf-alpha freisetzung |
| WO2006081072A1 (en) * | 2005-01-24 | 2006-08-03 | Abbott Laboratories | Antagonists of the mglu receptor and uses thereof |
| US20100143341A1 (en) * | 2005-06-22 | 2010-06-10 | Develogen Aktiengesellschaft | Thienopyrimidines for pharmaceutical compositions |
| CA2619362A1 (en) * | 2005-08-19 | 2007-03-01 | Schering Corporation | Fused tricyclic mglur1 antagonists as therapeutic agents |
| JP2009504752A (ja) * | 2005-08-19 | 2009-02-05 | シェーリング コーポレイション | 治療剤としての縮合三環式ｍＧｌｕＲ１アンタゴニスト |
| MX2009005009A (es) | 2006-11-09 | 2009-09-22 | Ardea Biosciences Inc | Compuestos heterociclicos biciclicos 4-cianofenilamino sustituidos como inhibidores del virus de inmunodeficiencia humana. |
| US20100227853A1 (en) | 2008-04-18 | 2010-09-09 | Trustees Of Boston College | Inhibitors of cyclic amp phosphodiesterases |
| AR073739A1 (es) | 2008-09-10 | 2010-12-01 | Kalypsys Inc | Aminopirimidinas como inhibidores de los receptores de histamina |
| WO2011029054A1 (en) | 2009-09-04 | 2011-03-10 | The Regents Of The University Of Michigan | Compositions and methods for treatment of leukemia |
| WO2012007375A1 (en) | 2010-07-13 | 2012-01-19 | F. Hoffmann-La Roche Ag | Pyrazolo [1, 5a] pyrimidine and thieno [3, 2b] pyrimidine derivatives as irak4 modulators |
| WO2012012712A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Tricyclic proteasome activity enhancing compounds |
| WO2012097013A1 (en) | 2011-01-10 | 2012-07-19 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| WO2013078126A1 (en) | 2011-11-23 | 2013-05-30 | Cancer Research Technology Limited | Thienopyrimidine inhibitors of atypical protein kinase c |
| TWI589579B (zh) | 2012-01-10 | 2017-07-01 | 林伯士艾瑞斯公司 | Ｉｒａｋ抑制劑及其用途 |
| US20140018361A1 (en) | 2012-07-11 | 2014-01-16 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| US9085586B2 (en) | 2012-07-11 | 2015-07-21 | Nimbus Iris, Inc. | IRAK inhibitors and uses thereof |
| IN2015DN00127A (US07846941-20101207-C00154.png) | 2012-07-11 | 2015-05-29 | Nimbus Iris Inc |
-
2013
- 2013-07-11 IN IN127DEN2015 patent/IN2015DN00127A/en unknown
- 2013-07-11 EP EP13817012.1A patent/EP2872518A4/en not_active Withdrawn
- 2013-07-11 US US13/939,816 patent/US9067948B2/en not_active Expired - Fee Related
- 2013-07-11 CA CA2878040A patent/CA2878040A1/en not_active Abandoned
- 2013-07-11 AU AU2013290080A patent/AU2013290080A1/en not_active Abandoned
- 2013-07-11 WO PCT/US2013/050113 patent/WO2014011906A2/en active Application Filing
- 2013-07-11 BR BR112015000561A patent/BR112015000561A2/pt not_active IP Right Cessation
- 2013-07-11 JP JP2015521817A patent/JP2015528801A/ja active Pending
- 2013-07-11 CN CN201380036906.2A patent/CN104902959A/zh active Pending
-
2015
- 2015-06-17 US US14/741,916 patent/US20160002256A1/en not_active Abandoned
- 2015-11-19 HK HK15111414.8A patent/HK1210732A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2872518A4 (en) | 2016-05-18 |
| IN2015DN00127A (US07846941-20101207-C00154.png) | 2015-05-29 |
| CA2878040A1 (en) | 2014-01-16 |
| AU2013290080A1 (en) | 2015-01-29 |
| US9067948B2 (en) | 2015-06-30 |
| HK1210732A1 (en) | 2016-05-06 |
| US20140018357A1 (en) | 2014-01-16 |
| WO2014011906A3 (en) | 2015-07-16 |
| EP2872518A2 (en) | 2015-05-20 |
| CN104902959A (zh) | 2015-09-09 |
| JP2015528801A (ja) | 2015-10-01 |
| US20160002256A1 (en) | 2016-01-07 |
| WO2014011906A2 (en) | 2014-01-16 |
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