BR112015000093A2 - processo para preparar oxamidas enantiomericamente enriquecidas - Google Patents

processo para preparar oxamidas enantiomericamente enriquecidas

Info

Publication number
BR112015000093A2
BR112015000093A2 BR112015000093A BR112015000093A BR112015000093A2 BR 112015000093 A2 BR112015000093 A2 BR 112015000093A2 BR 112015000093 A BR112015000093 A BR 112015000093A BR 112015000093 A BR112015000093 A BR 112015000093A BR 112015000093 A2 BR112015000093 A2 BR 112015000093A2
Authority
BR
Brazil
Prior art keywords
oxamides
enantiomerically enriched
preparing enantiomerically
preparation
dorzolamide
Prior art date
Application number
BR112015000093A
Other languages
English (en)
Inventor
Smaniotto Anna
Nardi Antonio
Munari Ilaria
Cotarca Livius
Verzini Massimo
Andretto Mauro
Volpicelli Raffaella
Brescello Roberto
Original Assignee
Zach System Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System Spa filed Critical Zach System Spa
Publication of BR112015000093A2 publication Critical patent/BR112015000093A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

resumo “processo para preparar oxamidas enantiomericamente enriquecidas” a presente invenção refere-se a um oxamida quiral de fórmula (i) útil como um intermediário na preparação de dorzolamida, e para a sua preparação. a invenção também se relaciona com a preparação de dorzolamida, para o seu sal cloridrato, e o ingrediente ativo contido num medicamento útil no tratamento do glaucoma, por meio de um intermediário de fórmula (i).
BR112015000093A 2012-07-03 2013-06-28 processo para preparar oxamidas enantiomericamente enriquecidas BR112015000093A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001165A ITMI20121165A1 (it) 2012-07-03 2012-07-03 Processo di riduzione asimmetrica
PCT/EP2013/063644 WO2014005943A1 (en) 2012-07-03 2013-06-28 Process for preparing enantiomerically enriched oxamides

Publications (1)

Publication Number Publication Date
BR112015000093A2 true BR112015000093A2 (pt) 2017-06-27

Family

ID=46982670

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015000093A BR112015000093A2 (pt) 2012-07-03 2013-06-28 processo para preparar oxamidas enantiomericamente enriquecidas

Country Status (10)

Country Link
US (1) US9481686B2 (pt)
EP (1) EP2870162A1 (pt)
JP (1) JP6276759B2 (pt)
CN (1) CN104411708B (pt)
AU (1) AU2013286077B2 (pt)
BR (1) BR112015000093A2 (pt)
CA (1) CA2876965C (pt)
IL (1) IL236262B (pt)
IT (1) ITMI20121165A1 (pt)
WO (1) WO2014005943A1 (pt)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
TW265343B (pt) * 1993-03-22 1995-12-11 Merck & Co Inc
WO2006070387A1 (en) * 2004-12-28 2006-07-06 Council Of Scientific And Industrial Research PROCESS FOR PREPARING 5,6-DIHYDRO-4-(S)-(ETHYLAMINO)-6-(S) METHYL-4H-THIENO[2,3b]THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE HCI
US8183391B2 (en) 2006-04-21 2012-05-22 Zach Systems S.P.A. Process for preparing dorzolamide
EP1918293A1 (en) * 2006-10-02 2008-05-07 Sandoz AG Process for the preparation of 6-substituted-4-oxo-thieno [2,3b]thiopyran-2-sulfonic acid
EP2152718A2 (en) * 2007-05-07 2010-02-17 Cipla Limited Process for preparing dorzolamide
WO2011101704A1 (en) * 2010-02-19 2011-08-25 Micro Labs Limited Process for preparing (4s, 6s)-4-(ethylamino)-5,6-dihydro-6-methyl-4h-thieno-[2,3-b]thiopyran-2-sulfonamide-7,7-dioxide and its intermediates
WO2012120086A1 (en) * 2011-03-10 2012-09-13 Zach System S.P.A. Asymmetric reduction process

Also Published As

Publication number Publication date
AU2013286077B2 (en) 2017-08-17
AU2013286077A1 (en) 2015-01-22
US20150191485A1 (en) 2015-07-09
EP2870162A1 (en) 2015-05-13
CN104411708A (zh) 2015-03-11
IL236262B (en) 2019-08-29
CN104411708B (zh) 2017-07-04
CA2876965A1 (en) 2014-01-09
ITMI20121165A1 (it) 2014-01-04
JP6276759B2 (ja) 2018-02-07
US9481686B2 (en) 2016-11-01
IL236262A0 (en) 2015-02-26
WO2014005943A1 (en) 2014-01-09
CA2876965C (en) 2019-07-23
JP2015521649A (ja) 2015-07-30

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL