BR112014028588B1 - Polipeptídeo, método de produzir um polipeptídeo que compreende o grupo bcn, método de produzir um polipeptídeo que compreende um grupo tetrazina, aminoácido e bcn lisina - Google Patents

Polipeptídeo, método de produzir um polipeptídeo que compreende o grupo bcn, método de produzir um polipeptídeo que compreende um grupo tetrazina, aminoácido e bcn lisina Download PDF

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Publication number
BR112014028588B1
BR112014028588B1 BR112014028588-8A BR112014028588A BR112014028588B1 BR 112014028588 B1 BR112014028588 B1 BR 112014028588B1 BR 112014028588 A BR112014028588 A BR 112014028588A BR 112014028588 B1 BR112014028588 B1 BR 112014028588B1
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BR
Brazil
Prior art keywords
bcn
polypeptide
amino acid
group
tetrazine
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BR112014028588-8A
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English (en)
Portuguese (pt)
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BR112014028588A2 (pt
BR112014028588A8 (pt
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Jason Chin
Kathrin Lang
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United Kingdom Research And Innovation
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Priority claimed from GBGB1208875.3A external-priority patent/GB201208875D0/en
Priority claimed from GBGB1210303.2A external-priority patent/GB201210303D0/en
Application filed by United Kingdom Research And Innovation filed Critical United Kingdom Research And Innovation
Publication of BR112014028588A2 publication Critical patent/BR112014028588A2/pt
Publication of BR112014028588A8 publication Critical patent/BR112014028588A8/pt
Publication of BR112014028588B1 publication Critical patent/BR112014028588B1/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13Labelling of peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2/00Peptides of undefined number of amino acids; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y601/00Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01026Pyrrolysine-tRNAPyl ligase (6.1.1.26)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112014028588-8A 2012-05-18 2013-05-15 Polipeptídeo, método de produzir um polipeptídeo que compreende o grupo bcn, método de produzir um polipeptídeo que compreende um grupo tetrazina, aminoácido e bcn lisina BR112014028588B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1208875.3 2012-05-18
GBGB1208875.3A GB201208875D0 (en) 2012-05-18 2012-05-18 Methods
GBGB1210303.2A GB201210303D0 (en) 2012-06-08 2012-06-08 Polypeptides and methods
GB1210303.2 2012-06-08
PCT/GB2013/051249 WO2013171485A1 (en) 2012-05-18 2013-05-15 Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase.

Publications (3)

Publication Number Publication Date
BR112014028588A2 BR112014028588A2 (pt) 2017-06-27
BR112014028588A8 BR112014028588A8 (pt) 2021-06-29
BR112014028588B1 true BR112014028588B1 (pt) 2023-03-21

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Country Status (8)

Country Link
US (3) US20150148525A1 (enExample)
EP (1) EP2852664B1 (enExample)
JP (1) JP6343604B2 (enExample)
CN (2) CN108410827B (enExample)
BR (1) BR112014028588B1 (enExample)
CA (1) CA2873793C (enExample)
IN (1) IN2014DN09922A (enExample)
WO (1) WO2013171485A1 (enExample)

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GB201817444D0 (en) 2018-10-26 2018-12-12 Res & Innovation Uk Methods and compositions
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CN115701451B (zh) * 2021-08-02 2023-08-01 宁波鲲鹏生物科技有限公司 高效引入赖氨酸衍生物的氨酰基-tRNA合成酶及其应用
CN121399272A (zh) 2023-04-28 2026-01-23 英国研究与创新署 基于tRNA的方法和相关组合物
GB202307998D0 (en) 2023-05-29 2023-07-12 Res & Innovation Uk Aminoacyl-irna synthetase sets
CN119613545B (zh) * 2024-12-16 2025-09-16 天津大学 非天然氨基酸修饰的抗ccl5纳米抗体

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Publication number Publication date
EP2852664B1 (en) 2017-09-06
US20150148525A1 (en) 2015-05-28
HK1208704A1 (en) 2016-03-11
WO2013171485A1 (en) 2013-11-21
IN2014DN09922A (enExample) 2015-08-14
CA2873793C (en) 2022-02-22
US20200271658A1 (en) 2020-08-27
JP2015523965A (ja) 2015-08-20
CN104718285A (zh) 2015-06-17
EP2852664A1 (en) 2015-04-01
US20230340013A1 (en) 2023-10-26
JP6343604B2 (ja) 2018-06-13
CN108410827B (zh) 2023-05-09
CN108410827A (zh) 2018-08-17
US11732001B2 (en) 2023-08-22
BR112014028588A2 (pt) 2017-06-27
BR112014028588A8 (pt) 2021-06-29
CA2873793A1 (en) 2013-11-21

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B25A Requested transfer of rights approved

Owner name: UNITED KINGDOM RESEARCH AND INNOVATION (GB)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/05/2013, OBSERVADAS AS CONDICOES LEGAIS