BR112014004577A2 - inibidor pi3k para uso no tratamento de câncer ósseo ou para prevenção por metástase de células cancerosas primárias para os ossos - Google Patents

inibidor pi3k para uso no tratamento de câncer ósseo ou para prevenção por metástase de células cancerosas primárias para os ossos

Info

Publication number
BR112014004577A2
BR112014004577A2 BR112014004577A BR112014004577A BR112014004577A2 BR 112014004577 A2 BR112014004577 A2 BR 112014004577A2 BR 112014004577 A BR112014004577 A BR 112014004577A BR 112014004577 A BR112014004577 A BR 112014004577A BR 112014004577 A2 BR112014004577 A2 BR 112014004577A2
Authority
BR
Brazil
Prior art keywords
bone cancer
prevention
metastatic
pi3k inhibitor
cancer cells
Prior art date
Application number
BR112014004577A
Other languages
English (en)
Inventor
De Giovanni Carla
Nanni Patrizia
Lollini Pier-Luigi
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112014004577A2 publication Critical patent/BR112014004577A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

resumo patente da invenção: "inibidor pi3k para uso no tratamento de câncer ósseo ou para prevenção por metástase de células cancerosas primárias para os ossos". a presente invenção refere-se a processos para o tratamento de câncer ósseo e de prevenção da disseminação metastática de câncer.
BR112014004577A 2011-09-01 2012-08-31 inibidor pi3k para uso no tratamento de câncer ósseo ou para prevenção por metástase de células cancerosas primárias para os ossos BR112014004577A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161530089P 2011-09-01 2011-09-01
PCT/EP2012/067019 WO2013030368A1 (en) 2011-09-01 2012-08-31 Pi3k inhibitor for use in the treatment of bone cancer or for preventing metastatic dissemination primary cancer cells into the bone

Publications (1)

Publication Number Publication Date
BR112014004577A2 true BR112014004577A2 (pt) 2017-04-04

Family

ID=46758773

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014004577A BR112014004577A2 (pt) 2011-09-01 2012-08-31 inibidor pi3k para uso no tratamento de câncer ósseo ou para prevenção por metástase de células cancerosas primárias para os ossos

Country Status (11)

Country Link
US (1) US20140213583A1 (pt)
EP (1) EP2750670A1 (pt)
JP (1) JP2014527542A (pt)
KR (1) KR20140059786A (pt)
CN (1) CN103764130A (pt)
AU (1) AU2012300835A1 (pt)
BR (1) BR112014004577A2 (pt)
CA (1) CA2846272A1 (pt)
MX (1) MX2014002470A (pt)
RU (1) RU2014112320A (pt)
WO (1) WO2013030368A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1033980C2 (nl) 2007-06-13 2008-12-16 Ellery John Rijkaart Draaggestel voor een rubberboot en werkwijze voor het losneembaar bevestigen van een rubberboot aan zo een draaggestel.
AU2012313888B2 (en) 2011-09-27 2016-03-31 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
UY34632A (es) 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
AP2015008707A0 (en) 2013-03-14 2015-09-30 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
AU2015254542A1 (en) * 2014-04-30 2016-11-17 Biomerix Corporation Agent, product and use
WO2017009751A1 (en) 2015-07-15 2017-01-19 Pfizer Inc. Pyrimidine derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004096129A2 (en) * 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
WO2009066084A1 (en) * 2007-11-21 2009-05-28 F. Hoffmann-La Roche Ag 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
US8193182B2 (en) * 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof

Also Published As

Publication number Publication date
MX2014002470A (es) 2014-07-24
US20140213583A1 (en) 2014-07-31
KR20140059786A (ko) 2014-05-16
WO2013030368A1 (en) 2013-03-07
EP2750670A1 (en) 2014-07-09
JP2014527542A (ja) 2014-10-16
RU2014112320A (ru) 2015-10-10
CA2846272A1 (en) 2013-03-07
CN103764130A (zh) 2014-04-30
AU2012300835A1 (en) 2014-03-13

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]