BR112014000078A2 - derivados de ácido carboxílico com um anel oxazolo[4,5-d]pirimidina - Google Patents

derivados de ácido carboxílico com um anel oxazolo[4,5-d]pirimidina

Info

Publication number
BR112014000078A2
BR112014000078A2 BR112014000078A BR112014000078A BR112014000078A2 BR 112014000078 A2 BR112014000078 A2 BR 112014000078A2 BR 112014000078 A BR112014000078 A BR 112014000078A BR 112014000078 A BR112014000078 A BR 112014000078A BR 112014000078 A2 BR112014000078 A2 BR 112014000078A2
Authority
BR
Brazil
Prior art keywords
carboxylic acid
acid derivatives
oxazolo
cycloalkyloxy
pyrimidine ring
Prior art date
Application number
BR112014000078A
Other languages
English (en)
Inventor
Dieter Kadereit
Katrin Hiss
Matthias Schäfer
Silke Haag-Diergarten
Stephanie Hachtel
Thomas Huebschle
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112014000078A2 publication Critical patent/BR112014000078A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

zusammenfassung cycloalkyloxy-carbonsäurederivate die vorliegende erfindung betrifft cycloalkyloxy-carbonsäurederivate der formel i worin a, r1, r2a,r2b, r2c, r3 und x wie in den ansprüchen angegeben definiert sind. die verbindungen der formel i eignen sich z.b. zur wundheilung. _____________________________________________________ tradução do resumo resumo patente de invenção: "derivados de ácido carboxílico com um anel oxazolo[4,5-d]pirimidina". i a presente invenção se refere aos derivados do ácido cicloalqui-loxi-carboxílico da fórmula (i), na qual a, r1, r2a, r2b, r2c, r3 e x são defini-dos tal como indicado nas reivindicações. os compostos da fórmula (i) são adequados, por exemplo, para a cicatrização de feridas.
BR112014000078A 2011-07-07 2012-07-06 derivados de ácido carboxílico com um anel oxazolo[4,5-d]pirimidina BR112014000078A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11305879 2011-07-07
EP12305527 2012-05-11
PCT/EP2012/063302 WO2013004828A1 (de) 2011-07-07 2012-07-06 Carbonsäurederivate mit einem oxazolo [4, 5-c] pyridinring

Publications (1)

Publication Number Publication Date
BR112014000078A2 true BR112014000078A2 (pt) 2016-10-18

Family

ID=46514336

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000078A BR112014000078A2 (pt) 2011-07-07 2012-07-06 derivados de ácido carboxílico com um anel oxazolo[4,5-d]pirimidina

Country Status (17)

Country Link
US (1) US8735402B2 (pt)
EP (1) EP2729475B8 (pt)
JP (1) JP5913586B2 (pt)
KR (1) KR20140061386A (pt)
CN (1) CN103797015B (pt)
AU (1) AU2012280208B2 (pt)
BR (1) BR112014000078A2 (pt)
CA (1) CA2841229C (pt)
DK (1) DK2729475T3 (pt)
ES (1) ES2547110T3 (pt)
HK (1) HK1192237A1 (pt)
IL (1) IL230313A (pt)
MX (1) MX369847B (pt)
MY (1) MY165099A (pt)
PT (1) PT2729475E (pt)
RU (1) RU2609003C2 (pt)
WO (1) WO2013004828A1 (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9321787B2 (en) 2011-07-07 2016-04-26 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3679682A (en) * 1970-04-23 1972-07-25 Fmc Corp CERTAIN 5H-ISOXAZOLO{8 5,4-d{9 PYRIMIDIN-4-ONES
US7060697B2 (en) * 2003-05-19 2006-06-13 Irm Llc Immunosuppressant compounds and compositions
JP2011524864A (ja) * 2008-05-30 2011-09-08 メルク・シャープ・エンド・ドーム・コーポレイション 新規な置換されたアザベンゾオキサゾール
TW201000099A (en) 2008-06-20 2010-01-01 Amgen Inc S1P1 receptor agonists and use thereof
EP2318415B1 (en) 2008-07-15 2013-02-20 Sanofi Oxazolopyrimidines as edg-1 receptor agonists
US8907093B2 (en) * 2011-07-07 2014-12-09 Sanofi Carboxylic acid derivatives having an oxazolo[4,5-c]pyridine ring

Also Published As

Publication number Publication date
KR20140061386A (ko) 2014-05-21
EP2729475B1 (de) 2015-06-10
EP2729475A1 (de) 2014-05-14
IL230313A (en) 2016-08-31
MY165099A (en) 2018-02-28
MX2014000033A (es) 2014-02-17
CN103797015B (zh) 2015-12-09
WO2013004828A1 (de) 2013-01-10
AU2012280208A1 (en) 2014-02-06
CA2841229A1 (en) 2013-01-10
JP2014518249A (ja) 2014-07-28
CA2841229C (en) 2019-07-30
AU2012280208B2 (en) 2016-07-21
MX369847B (es) 2019-11-25
CN103797015A (zh) 2014-05-14
PT2729475E (pt) 2015-10-14
RU2014104233A (ru) 2015-08-20
EP2729475B8 (de) 2015-08-26
HK1192237A1 (en) 2014-08-15
US8735402B2 (en) 2014-05-27
RU2609003C2 (ru) 2017-01-30
DK2729475T3 (en) 2015-09-21
ES2547110T3 (es) 2015-10-01
JP5913586B2 (ja) 2016-04-27
US20130023545A1 (en) 2013-01-24

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2521 DE 30-04-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.