BR112013028655A8 - Anticorpos anti-fator de crescimento neuronal, composição farmacêutica compreendendo os mesmos e kit para o tratamento de dor em felinos - Google Patents
Anticorpos anti-fator de crescimento neuronal, composição farmacêutica compreendendo os mesmos e kit para o tratamento de dor em felinosInfo
- Publication number
- BR112013028655A8 BR112013028655A8 BR112013028655A BR112013028655A BR112013028655A8 BR 112013028655 A8 BR112013028655 A8 BR 112013028655A8 BR 112013028655 A BR112013028655 A BR 112013028655A BR 112013028655 A BR112013028655 A BR 112013028655A BR 112013028655 A8 BR112013028655 A8 BR 112013028655A8
- Authority
- BR
- Brazil
- Prior art keywords
- growth factor
- feline
- neuronal growth
- pain
- felines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/467—Igs with modifications in the FR-residues only
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
ANTICORPOS ANTI-FATOR DE CRESCIMENTO NEURONAL E MÉTODO PARA PREPARAÇÃO E UTILIZAÇÃO DOS MESMOS É fornecido um método de preparação de um anticorpo adequado para uso em um felino. Também são fornecidos anticorpos quiméricos e "felinizados" que se ligam especificamente ao fator crescimento neuronal felino (NGF) e neutralizam a habilidade do NGF felino para se ligar ao receptor de NGF felino p75 ou TrkA. A invenção se estende aos ácidos nucléicos que o codificam e aos métodos de tratamento de dor e artrite em um felino usando os referidos anticorpos e/ou ácidos nucléicos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161483488P | 2011-05-06 | 2011-05-06 | |
US61/483,488 | 2011-05-06 | ||
US201161531439P | 2011-09-06 | 2011-09-06 | |
US61/531,439 | 2011-09-06 | ||
PCT/GB2012/051003 WO2012153122A1 (en) | 2011-05-06 | 2012-05-08 | Anti-nerve growth factor antibodies and methods of preparing and using the same |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112013028655A2 BR112013028655A2 (pt) | 2016-11-29 |
BR112013028655A8 true BR112013028655A8 (pt) | 2017-12-26 |
BR112013028655B1 BR112013028655B1 (pt) | 2022-08-16 |
Family
ID=46168540
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013028655-5A BR112013028655B1 (pt) | 2011-05-06 | 2012-05-08 | Anticorpos anti-fator de crescimento neuronal, composição farmacêutica compreendendo os mesmos e kit para o tratamento de dor em felinos |
Country Status (13)
Country | Link |
---|---|
US (2) | US9328164B2 (pt) |
EP (2) | EP3498732B1 (pt) |
JP (1) | JP6258194B2 (pt) |
KR (2) | KR20170070272A (pt) |
CN (1) | CN103732621B (pt) |
AU (1) | AU2012252152B2 (pt) |
BR (1) | BR112013028655B1 (pt) |
ES (1) | ES2704037T3 (pt) |
GB (1) | GB2504887B (pt) |
MY (1) | MY161394A (pt) |
RU (1) | RU2640254C2 (pt) |
SG (2) | SG194793A1 (pt) |
WO (1) | WO2012153122A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
AU2011336470B8 (en) | 2010-12-01 | 2017-09-14 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
GB201114858D0 (en) | 2011-08-29 | 2011-10-12 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of using the same |
GB2528401A (en) | 2011-05-06 | 2016-01-20 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
EP2983711A4 (en) * | 2013-04-08 | 2016-11-23 | Cytodyn Inc | FELLINED ANTIBODIES AND METHODS OF TREATING RETROVIRAL INFECTIONS IN FELINES |
CN113402609B (zh) | 2013-12-20 | 2023-12-05 | 英特维特国际股份有限公司 | 具有经修饰的ch2-ch3序列的犬抗体 |
WO2016050721A1 (en) | 2014-09-30 | 2016-04-07 | Intervet International B.V. | Pd-l1 antibodies binding canine pd-l1 |
BR112017025029A2 (pt) * | 2015-05-22 | 2018-08-07 | Astellas Pharma Inc. | ?novo fragmento fab de anticorpo ngf anti- humano?. |
US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
WO2019177690A1 (en) | 2018-03-12 | 2019-09-19 | Zoetis Services Llc | Anti-ngf antibodies and methods thereof |
GB2578867A (en) * | 2018-10-09 | 2020-06-03 | Genome Res Ltd | Animal models and therapeutic molecules |
CN110283246A (zh) * | 2019-06-20 | 2019-09-27 | 长春西诺生物科技有限公司 | 一种抗猫细小病毒的猫源化基因工程抗体 |
WO2021176362A1 (en) * | 2020-03-03 | 2021-09-10 | Scout Bio, Inc. | Antigen-binding molecules and uses thereof |
CN117062837A (zh) | 2021-05-12 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 特异性结合rankl和ngf的抗原结合分子及其医药用途 |
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CA2022959C (en) * | 1989-08-10 | 2001-03-20 | Hiroaki Maeda | Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin |
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DK1024191T3 (da) | 1991-12-02 | 2008-12-08 | Medical Res Council | Fremstilling af autoantistoffer fremvist på fag-overflader ud fra antistofsegmentbiblioteker |
GB9202796D0 (en) | 1992-02-11 | 1992-03-25 | Wellcome Found | Antiviral antibody |
SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
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ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
DK2206728T3 (en) * | 2004-04-07 | 2018-04-23 | Rinat Neuroscience Corp | METHODS OF TREATING BONE CANCER PAIN BY SUBMITTING A NERVOUS FACTOR-ANTAGONISTIC ANTIBODY |
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ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
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-
2012
- 2012-05-08 EP EP18205428.8A patent/EP3498732B1/en active Active
- 2012-05-08 GB GB1320046.4A patent/GB2504887B/en active Active
- 2012-05-08 CN CN201280033596.4A patent/CN103732621B/zh active Active
- 2012-05-08 SG SG2013081898A patent/SG194793A1/en unknown
- 2012-05-08 ES ES12723731T patent/ES2704037T3/es active Active
- 2012-05-08 BR BR112013028655-5A patent/BR112013028655B1/pt active IP Right Grant
- 2012-05-08 WO PCT/GB2012/051003 patent/WO2012153122A1/en active Application Filing
- 2012-05-08 SG SG10201500953YA patent/SG10201500953YA/en unknown
- 2012-05-08 KR KR1020177016066A patent/KR20170070272A/ko not_active Application Discontinuation
- 2012-05-08 KR KR1020137032544A patent/KR101783929B1/ko active IP Right Grant
- 2012-05-08 MY MYPI2013702080A patent/MY161394A/en unknown
- 2012-05-08 AU AU2012252152A patent/AU2012252152B2/en active Active
- 2012-05-08 RU RU2013154301A patent/RU2640254C2/ru not_active Application Discontinuation
- 2012-05-08 JP JP2014509818A patent/JP6258194B2/ja active Active
- 2012-05-08 EP EP12723731.1A patent/EP2705055B1/en active Active
- 2012-05-08 US US14/115,787 patent/US9328164B2/en active Active
-
2016
- 2016-03-28 US US15/082,541 patent/US20160272701A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2012252152B2 (en) | 2016-07-07 |
SG194793A1 (en) | 2013-12-30 |
RU2013154301A (ru) | 2015-06-20 |
ES2704037T3 (es) | 2019-03-13 |
EP2705055B1 (en) | 2018-11-14 |
KR20170070272A (ko) | 2017-06-21 |
KR20140047048A (ko) | 2014-04-21 |
EP3498732B1 (en) | 2021-11-17 |
AU2012252152A1 (en) | 2013-11-14 |
EP2705055A1 (en) | 2014-03-12 |
US20160272701A1 (en) | 2016-09-22 |
BR112013028655A2 (pt) | 2016-11-29 |
MY161394A (en) | 2017-04-14 |
GB2504887A (en) | 2014-02-12 |
KR101783929B1 (ko) | 2017-10-11 |
EP3498732A1 (en) | 2019-06-19 |
RU2640254C2 (ru) | 2017-12-27 |
WO2012153122A1 (en) | 2012-11-15 |
GB201320046D0 (en) | 2013-12-25 |
US20140147439A1 (en) | 2014-05-29 |
JP2014519317A (ja) | 2014-08-14 |
GB2504887B (en) | 2016-02-03 |
CN103732621A (zh) | 2014-04-16 |
NZ617447A (en) | 2015-01-30 |
SG10201500953YA (en) | 2015-04-29 |
JP6258194B2 (ja) | 2018-01-10 |
CN103732621B (zh) | 2020-04-24 |
US9328164B2 (en) | 2016-05-03 |
BR112013028655B1 (pt) | 2022-08-16 |
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