BR112013027075A2 - 4-[(haloalquil)-(dsimetil)-amônio] butanoatos, processos de preparação e seus usos no tratamento de doenças cardiovasculares - Google Patents

4-[(haloalquil)-(dsimetil)-amônio] butanoatos, processos de preparação e seus usos no tratamento de doenças cardiovasculares

Info

Publication number
BR112013027075A2
BR112013027075A2 BR112013027075A BR112013027075A BR112013027075A2 BR 112013027075 A2 BR112013027075 A2 BR 112013027075A2 BR 112013027075 A BR112013027075 A BR 112013027075A BR 112013027075 A BR112013027075 A BR 112013027075A BR 112013027075 A2 BR112013027075 A2 BR 112013027075A2
Authority
BR
Brazil
Prior art keywords
butanoates
haloalkyl
ammonium
treatment
cardiovascular disease
Prior art date
Application number
BR112013027075A
Other languages
English (en)
Inventor
Daina Gustina
Daina Lola
Edgars Liepins
Einars Loza
Ilmars Stonans
Ivars Kalvins
Janis Kuka
Maija Dambrova
Marina Makrecka
Osvalds Pugovics
Solveiga Grinberga
Viktors Andrianovs
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of BR112013027075A2 publication Critical patent/BR112013027075A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo "4-[(haloalquil)-(dimetil)-amônio] butanoatos, processos de preparação e seus usos no tratamento de doenças cardiovasculares" a presente invenção refere-se aos 4-[(haloalquil)-(dimetil)- amônio] butanoatos, de fórmula (i), onde hal é cl ou f, n = 1 ou 2, seus processos de preparação dos mesmos e seus usos no tratamento de doenças cardiovasculares. [pic]
BR112013027075A 2011-04-27 2012-04-27 4-[(haloalquil)-(dsimetil)-amônio] butanoatos, processos de preparação e seus usos no tratamento de doenças cardiovasculares BR112013027075A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11163838 2011-04-27
EP11163837 2011-04-27
EP11163842 2011-04-27
PCT/EP2012/057807 WO2012146737A1 (en) 2011-04-27 2012-04-27 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease

Publications (1)

Publication Number Publication Date
BR112013027075A2 true BR112013027075A2 (pt) 2016-12-27

Family

ID=46046159

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013027075A BR112013027075A2 (pt) 2011-04-27 2012-04-27 4-[(haloalquil)-(dsimetil)-amônio] butanoatos, processos de preparação e seus usos no tratamento de doenças cardiovasculares

Country Status (8)

Country Link
US (1) US8940793B2 (pt)
EP (1) EP2702037A1 (pt)
CN (1) CN103547562A (pt)
AU (1) AU2012247468A1 (pt)
BR (1) BR112013027075A2 (pt)
EA (1) EA201301079A1 (pt)
WO (1) WO2012146737A1 (pt)
ZA (1) ZA201307847B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV14345B (lv) * 2009-10-22 2011-07-20 Grindeks, A/S 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1238868A (pt) 1967-08-08 1971-07-14
SU997646A1 (ru) 1978-11-27 1983-02-23 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Кормова добавка
IT1210935B (it) 1981-09-17 1989-09-29 Inst Orch Sinteza Akademi Nauk Composizione farmaceutica per il trattamento di malattie cardiovascolari.
JP3119430B2 (ja) * 1995-07-25 2000-12-18 大鵬薬品工業株式会社 水酸基ラジカル消去剤
LV11728B (en) 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition
US5973026A (en) 1998-02-02 1999-10-26 Xerox Corporation Ink jet inks
LV13280B (en) * 2003-08-04 2005-11-20 Grindeks Publiska As Sustained release salts of 3-(2,2,2-trimethylhydrazinium)propionate, a method of production and pharmaceutical compositions thereof
CA2508094A1 (en) 2005-05-20 2006-11-20 Vivier Canada Inc. Composition for accelerating collagen synthesis
US7863274B2 (en) 2005-07-29 2011-01-04 Concert Pharmaceuticals Inc. Deuterium enriched analogues of tadalafil as PDE5 inhibitors
LV13705B (en) 2006-11-06 2008-07-20 Ivars Kalvins Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide
JP4761265B2 (ja) 2007-10-17 2011-08-31 学校法人甲南学園 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法
CN102803199B (zh) * 2009-06-25 2015-04-15 泰特拉有限公司 乙酰水杨酸盐

Also Published As

Publication number Publication date
WO2012146737A1 (en) 2012-11-01
US20140107202A1 (en) 2014-04-17
EP2702037A1 (en) 2014-03-05
US8940793B2 (en) 2015-01-27
AU2012247468A1 (en) 2013-11-14
CN103547562A (zh) 2014-01-29
EA201301079A1 (ru) 2014-02-28
ZA201307847B (en) 2014-11-26

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Legal Events

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B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE AS 4A E 5A ANUIDADES.

B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)