EA201301079A1 - 4-[(галоидалкил)(диметил)аммоний]бутаноаты и их применение при лечении сердечно-сосудистого заболевания - Google Patents

4-[(галоидалкил)(диметил)аммоний]бутаноаты и их применение при лечении сердечно-сосудистого заболевания

Info

Publication number
EA201301079A1
EA201301079A1 EA201301079A EA201301079A EA201301079A1 EA 201301079 A1 EA201301079 A1 EA 201301079A1 EA 201301079 A EA201301079 A EA 201301079A EA 201301079 A EA201301079 A EA 201301079A EA 201301079 A1 EA201301079 A1 EA 201301079A1
Authority
EA
Eurasian Patent Office
Prior art keywords
butanoates
dimethyl
ammonium
treatment
haloidalkil
Prior art date
Application number
EA201301079A
Other languages
English (en)
Inventor
Иварс Калвиньш
Эдгарс Лепиньш
Эйнарс Лоза
Мая Дамброва
Илмарс Стонанс
Дайна Лола
Янис Кука
Освальд Пугович
Виктор Андрианов
Марина Макреска
Дайна Густина
Сольвейга Гринберга
Original Assignee
Гриндекс, Джоинт Сток Кампани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Гриндекс, Джоинт Сток Кампани filed Critical Гриндекс, Джоинт Сток Кампани
Publication of EA201301079A1 publication Critical patent/EA201301079A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

4-[(Галоидалкил)(диметил)аммоний]бутаноаты формулыгде Hal означает Cl или F, n=1 или 2, способ их получения и применения при лечении сердечно-сосудистых заболеваний.
EA201301079A 2011-04-27 2012-04-27 4-[(галоидалкил)(диметил)аммоний]бутаноаты и их применение при лечении сердечно-сосудистого заболевания EA201301079A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11163838 2011-04-27
EP11163842 2011-04-27
EP11163837 2011-04-27
PCT/EP2012/057807 WO2012146737A1 (en) 2011-04-27 2012-04-27 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease

Publications (1)

Publication Number Publication Date
EA201301079A1 true EA201301079A1 (ru) 2014-02-28

Family

ID=46046159

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201301079A EA201301079A1 (ru) 2011-04-27 2012-04-27 4-[(галоидалкил)(диметил)аммоний]бутаноаты и их применение при лечении сердечно-сосудистого заболевания

Country Status (8)

Country Link
US (1) US8940793B2 (ru)
EP (1) EP2702037A1 (ru)
CN (1) CN103547562A (ru)
AU (1) AU2012247468A1 (ru)
BR (1) BR112013027075A2 (ru)
EA (1) EA201301079A1 (ru)
WO (1) WO2012146737A1 (ru)
ZA (1) ZA201307847B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV14345B (lv) * 2009-10-22 2011-07-20 Grindeks, A/S 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1238868A (ru) 1967-08-08 1971-07-14
SU997646A1 (ru) 1978-11-27 1983-02-23 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Кормова добавка
IT1210935B (it) * 1981-09-17 1989-09-29 Inst Orch Sinteza Akademi Nauk Composizione farmaceutica per il trattamento di malattie cardiovascolari.
JP3119430B2 (ja) * 1995-07-25 2000-12-18 大鵬薬品工業株式会社 水酸基ラジカル消去剤
LV11728B (en) * 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition
US5973026A (en) 1998-02-02 1999-10-26 Xerox Corporation Ink jet inks
LV13280B (en) * 2003-08-04 2005-11-20 Grindeks Publiska As Sustained release salts of 3-(2,2,2-trimethylhydrazinium)propionate, a method of production and pharmaceutical compositions thereof
CA2508094A1 (en) 2005-05-20 2006-11-20 Vivier Canada Inc. Composition for accelerating collagen synthesis
US7863274B2 (en) 2005-07-29 2011-01-04 Concert Pharmaceuticals Inc. Deuterium enriched analogues of tadalafil as PDE5 inhibitors
LV13705B (en) 2006-11-06 2008-07-20 Ivars Kalvins Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide
JP4761265B2 (ja) 2007-10-17 2011-08-31 学校法人甲南学園 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法
BRPI1009600A2 (ru) * 2009-06-25 2016-03-22 Tetra S A

Also Published As

Publication number Publication date
EP2702037A1 (en) 2014-03-05
US20140107202A1 (en) 2014-04-17
BR112013027075A2 (pt) 2016-12-27
ZA201307847B (en) 2014-11-26
AU2012247468A1 (en) 2013-11-14
WO2012146737A1 (en) 2012-11-01
CN103547562A (zh) 2014-01-29
US8940793B2 (en) 2015-01-27

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