BR112013023057A2 - inibidores de peptídeo deformilase - Google Patents

inibidores de peptídeo deformilase

Info

Publication number
BR112013023057A2
BR112013023057A2 BR112013023057A BR112013023057A BR112013023057A2 BR 112013023057 A2 BR112013023057 A2 BR 112013023057A2 BR 112013023057 A BR112013023057 A BR 112013023057A BR 112013023057 A BR112013023057 A BR 112013023057A BR 112013023057 A2 BR112013023057 A2 BR 112013023057A2
Authority
BR
Brazil
Prior art keywords
peptide deformylase
deformylase inhibitors
inhibitors
peptide
deformylase
Prior art date
Application number
BR112013023057A
Other languages
English (en)
Inventor
Andrew B Benowitz
Andrew Nicholson Knox
Donghui Qin
James Hoffman
Joseph Karpinski
Kelly M Aubart
Xiangmin Liao
Yuhong Fang
Original Assignee
Glaxosmithkline Intelectual Property No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Intelectual Property No 2 Ltd filed Critical Glaxosmithkline Intelectual Property No 2 Ltd
Publication of BR112013023057A2 publication Critical patent/BR112013023057A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06139Dipeptides with the first amino acid being heterocyclic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y305/00Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01088Peptide deformylase (3.5.1.88)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112013023057A 2011-03-09 2012-03-09 inibidores de peptídeo deformilase BR112013023057A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161450784P 2011-03-09 2011-03-09
PCT/US2012/028424 WO2012122450A2 (en) 2011-03-09 2012-03-09 Peptide deformylase inhibitors

Publications (1)

Publication Number Publication Date
BR112013023057A2 true BR112013023057A2 (pt) 2016-08-02

Family

ID=46798826

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013023057A BR112013023057A2 (pt) 2011-03-09 2012-03-09 inibidores de peptídeo deformilase

Country Status (22)

Country Link
US (1) US8901119B2 (pt)
EP (1) EP2684039A4 (pt)
JP (1) JP2014516917A (pt)
KR (1) KR20140011362A (pt)
CN (1) CN103827665A (pt)
AR (1) AR085698A1 (pt)
AU (1) AU2012225365A1 (pt)
BR (1) BR112013023057A2 (pt)
CA (1) CA2829361A1 (pt)
CL (1) CL2013002584A1 (pt)
CO (1) CO6761343A2 (pt)
CR (1) CR20130522A (pt)
DO (1) DOP2013000206A (pt)
EA (1) EA201391299A1 (pt)
MA (1) MA35010B1 (pt)
MX (1) MX2013010339A (pt)
PE (1) PE20140439A1 (pt)
SG (1) SG192948A1 (pt)
TW (1) TW201249824A (pt)
UY (1) UY33939A (pt)
WO (1) WO2012122450A2 (pt)
ZA (1) ZA201306415B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101383565B1 (ko) 2013-03-21 2014-04-09 박용희 고효율 해수 증발 장치 및 증발로프 모듈
GB201409536D0 (en) 2014-05-29 2014-07-16 Univ The Durham Chemically modifying peptides
CN109851614B (zh) * 2019-03-29 2023-01-13 中山大学 一类杂环类肽脱甲酰基酶抑制剂及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250700A (en) 1991-05-01 1993-10-05 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
US5399708A (en) 1993-11-12 1995-03-21 Eli Lilly And Company Pyrazolidin-3-one derivatives
UY27813A1 (es) 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
ES2285444T3 (es) 2003-04-03 2007-11-16 Merck Patent Gmbh Derivados de la 1-(fenil)-amida)-2-(fenil)-amida) del acido pirazolidin-1,2-dicarboxilico como inhibidores del factor de coagulacion xa para el tratamiento de la trombosis.
MX2007015419A (es) * 2005-06-08 2008-02-21 Novartis Ag Compuestos organicos.
KR20080095895A (ko) * 2006-03-03 2008-10-29 노파르티스 아게 N―포르밀 히드록실아민 화합물
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
WO2011008548A1 (en) * 2009-06-29 2011-01-20 Genocea Biosciences, Inc. Vaccines and compositions against streptococcus pneumoniae

Also Published As

Publication number Publication date
UY33939A (es) 2012-09-28
KR20140011362A (ko) 2014-01-28
US8901119B2 (en) 2014-12-02
CO6761343A2 (es) 2013-09-30
SG192948A1 (en) 2013-09-30
US20130345120A1 (en) 2013-12-26
PE20140439A1 (es) 2014-05-04
CA2829361A1 (en) 2012-09-13
AU2012225365A1 (en) 2013-09-12
CN103827665A (zh) 2014-05-28
AU2012225365A8 (en) 2013-09-19
JP2014516917A (ja) 2014-07-17
EP2684039A4 (en) 2015-03-11
CL2013002584A1 (es) 2014-02-21
MA35010B1 (fr) 2014-04-03
EP2684039A2 (en) 2014-01-15
WO2012122450A2 (en) 2012-09-13
AR085698A1 (es) 2013-10-23
ZA201306415B (en) 2014-04-30
DOP2013000206A (es) 2014-01-31
EA201391299A1 (ru) 2014-02-28
TW201249824A (en) 2012-12-16
MX2013010339A (es) 2013-10-03
CR20130522A (es) 2014-05-02
WO2012122450A3 (en) 2014-04-03

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]