CR20130522A - Inhibidores de la péptido desformilasa - Google Patents

Inhibidores de la péptido desformilasa

Info

Publication number
CR20130522A
CR20130522A CR20130522A CR20130522A CR20130522A CR 20130522 A CR20130522 A CR 20130522A CR 20130522 A CR20130522 A CR 20130522A CR 20130522 A CR20130522 A CR 20130522A CR 20130522 A CR20130522 A CR 20130522A
Authority
CR
Costa Rica
Prior art keywords
desformilasa
peptide
inhibitors
compound
bacterial
Prior art date
Application number
CR20130522A
Other languages
English (en)
Inventor
Kelly M Aubart
Andrew B Benowitz
Yuhong Fang
James Hoffman
Joseph M Karpinski
Andrew Nicholson Knox
Xiangmin Liao
Donghui Qin
Original Assignee
Glaxosmithkline Ip No 2 Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Ip No 2 Ltd filed Critical Glaxosmithkline Ip No 2 Ltd
Publication of CR20130522A publication Critical patent/CR20130522A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01088—Peptide deformylase (3.5.1.88)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto de Fórmula (I): a una sal farmacéuticamente aceptable del mismo, composiciones farmacéuticas correspondientes, preparación del compuesto y procedimientos de tratamiento dirigidos a infecciones bacterianas e inhibición de la actividad de la péptido desformilasa (PDF) bacteriana.
CR20130522A 2011-03-09 2013-10-09 Inhibidores de la péptido desformilasa CR20130522A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161450784P 2011-03-09 2011-03-09

Publications (1)

Publication Number Publication Date
CR20130522A true CR20130522A (es) 2014-05-02

Family

ID=46798826

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20130522A CR20130522A (es) 2011-03-09 2013-10-09 Inhibidores de la péptido desformilasa

Country Status (22)

Country Link
US (1) US8901119B2 (es)
EP (1) EP2684039A4 (es)
JP (1) JP2014516917A (es)
KR (1) KR20140011362A (es)
CN (1) CN103827665A (es)
AR (1) AR085698A1 (es)
AU (1) AU2012225365A1 (es)
BR (1) BR112013023057A2 (es)
CA (1) CA2829361A1 (es)
CL (1) CL2013002584A1 (es)
CO (1) CO6761343A2 (es)
CR (1) CR20130522A (es)
DO (1) DOP2013000206A (es)
EA (1) EA201391299A1 (es)
MA (1) MA35010B1 (es)
MX (1) MX2013010339A (es)
PE (1) PE20140439A1 (es)
SG (1) SG192948A1 (es)
TW (1) TW201249824A (es)
UY (1) UY33939A (es)
WO (1) WO2012122450A2 (es)
ZA (1) ZA201306415B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101383565B1 (ko) 2013-03-21 2014-04-09 박용희 고효율 해수 증발 장치 및 증발로프 모듈
GB201409536D0 (en) 2014-05-29 2014-07-16 Univ The Durham Chemically modifying peptides
CN109851614B (zh) * 2019-03-29 2023-01-13 中山大学 一类杂环类肽脱甲酰基酶抑制剂及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250700A (en) 1991-05-01 1993-10-05 American Home Products Corporation Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents
US5399708A (en) * 1993-11-12 1995-03-21 Eli Lilly And Company Pyrazolidin-3-one derivatives
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
KR20050109617A (ko) * 2003-04-03 2005-11-21 메르크 파텐트 게엠베하 혈전증 치료용 응집 인자 ｘａ 저해제로서의피라졸리딘-１,２-디카르복실디페닐아미드 유도체
MX2007015419A (es) * 2005-06-08 2008-02-21 Novartis Ag Compuestos organicos.
KR20080095895A (ko) * 2006-03-03 2008-10-29 노파르티스 아게 Ｎ―포르밀 히드록실아민 화합물
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
CN101584694B (zh) * 2009-06-15 2011-01-12 华东师范大学 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法
BRPI1011919A2 (pt) * 2009-06-29 2017-09-26 Childrens Medical Center vacinas e composições contra streptococcus pneumoniae

Also Published As

Publication number Publication date
TW201249824A (en) 2012-12-16
EP2684039A2 (en) 2014-01-15
US20130345120A1 (en) 2013-12-26
CL2013002584A1 (es) 2014-02-21
WO2012122450A2 (en) 2012-09-13
MA35010B1 (fr) 2014-04-03
CA2829361A1 (en) 2012-09-13
EA201391299A1 (ru) 2014-02-28
UY33939A (es) 2012-09-28
AU2012225365A8 (en) 2013-09-19
AR085698A1 (es) 2013-10-23
JP2014516917A (ja) 2014-07-17
DOP2013000206A (es) 2014-01-31
PE20140439A1 (es) 2014-05-04
AU2012225365A1 (en) 2013-09-12
CN103827665A (zh) 2014-05-28
CO6761343A2 (es) 2013-09-30
SG192948A1 (en) 2013-09-30
KR20140011362A (ko) 2014-01-28
US8901119B2 (en) 2014-12-02
ZA201306415B (en) 2014-04-30
EP2684039A4 (en) 2015-03-11
BR112013023057A2 (pt) 2016-08-02
WO2012122450A3 (en) 2014-04-03
MX2013010339A (es) 2013-10-03

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