BR112013018298A2 - compostos para a redução da produção de beta-amiloides - Google Patents
compostos para a redução da produção de beta-amiloidesInfo
- Publication number
- BR112013018298A2 BR112013018298A2 BR112013018298A BR112013018298A BR112013018298A2 BR 112013018298 A2 BR112013018298 A2 BR 112013018298A2 BR 112013018298 A BR112013018298 A BR 112013018298A BR 112013018298 A BR112013018298 A BR 112013018298A BR 112013018298 A2 BR112013018298 A2 BR 112013018298A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- reducing beta
- amyloid
- amyloid production
- production
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161437279P | 2011-01-28 | 2011-01-28 | |
| PCT/US2012/022665 WO2012103297A1 (en) | 2011-01-28 | 2012-01-26 | COMPOUNDS FOR THE REDUCTION OF β-AMYLOID PRODUCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013018298A2 true BR112013018298A2 (pt) | 2016-11-16 |
Family
ID=45688981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013018298A BR112013018298A2 (pt) | 2011-01-28 | 2012-01-26 | compostos para a redução da produção de beta-amiloides |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8710061B2 (https=) |
| EP (1) | EP2668168B1 (https=) |
| JP (1) | JP5908499B2 (https=) |
| KR (1) | KR20140014152A (https=) |
| CN (1) | CN103328451B (https=) |
| AR (1) | AR084944A1 (https=) |
| AU (1) | AU2012211301B2 (https=) |
| BR (1) | BR112013018298A2 (https=) |
| CA (1) | CA2825906A1 (https=) |
| EA (1) | EA201391097A1 (https=) |
| IL (1) | IL226677A (https=) |
| MX (1) | MX2013008699A (https=) |
| SG (1) | SG191840A1 (https=) |
| TW (1) | TW201309655A (https=) |
| WO (1) | WO2012103297A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015025686B1 (pt) | 2013-04-15 | 2020-10-27 | Fmc Corporation | composto, composições fungicidas e método para o controle das doenças dos vegetais |
| JP6688503B2 (ja) * | 2014-11-21 | 2020-04-28 | 大学共同利用機関法人自然科学研究機構 | 医薬用組成物 |
| AU2016219102B2 (en) * | 2015-02-13 | 2020-10-15 | Dana-Farber Cancer Institute, Inc. | LRRK2 inhibitors and methods of making and using the same |
| CN105017046A (zh) * | 2015-07-15 | 2015-11-04 | 上海博康精细化工有限公司 | 一种4-环丙胺基丁酸乙酯的制备方法 |
| KR102591886B1 (ko) * | 2015-07-21 | 2023-10-20 | 광저우 맥시노벨 파마수티컬스 씨오., 엘티디. | 축합고리 피리미딘계 화합물, 중간체, 이의 제조 방법, 조성물 및 응용 |
| JP7335242B2 (ja) * | 2017-11-27 | 2023-08-29 | エフ． ホフマン－ラ ロシュ アーゲー | ピリミジン誘導体 |
| PH12021551635A1 (en) | 2019-01-29 | 2022-05-02 | Shandong Xuanzhu Pharma Co Ltd | Hexone glucokinase inhibitor and use thereof |
| CN112028839B (zh) * | 2020-09-30 | 2022-04-12 | 中国海洋大学 | 一种医药中间体环烷烃并嘧啶二酮化合物的合成方法 |
| TW202317528A (zh) * | 2021-06-24 | 2023-05-01 | 美商富曼西公司 | 用於防治無脊椎有害生物的唑類化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1318997T1 (sl) * | 2000-09-15 | 2006-12-31 | Vertex Pharma | Pirazolne spojine, uporabne kot inhibitorji protein-kinaze |
| WO2009084695A1 (ja) * | 2007-12-28 | 2009-07-09 | Carna Biosciences Inc. | ２－アミノキナゾリン誘導体 |
| TW201030002A (en) * | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| US8637525B2 (en) * | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| TWI468402B (zh) * | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β－類澱粉生成之化合物 |
-
2012
- 2012-01-17 TW TW101101816A patent/TW201309655A/zh unknown
- 2012-01-26 WO PCT/US2012/022665 patent/WO2012103297A1/en not_active Ceased
- 2012-01-26 BR BR112013018298A patent/BR112013018298A2/pt not_active IP Right Cessation
- 2012-01-26 JP JP2013551323A patent/JP5908499B2/ja not_active Expired - Fee Related
- 2012-01-26 MX MX2013008699A patent/MX2013008699A/es unknown
- 2012-01-26 SG SG2013051552A patent/SG191840A1/en unknown
- 2012-01-26 EA EA201391097A patent/EA201391097A1/ru unknown
- 2012-01-26 US US13/358,822 patent/US8710061B2/en active Active
- 2012-01-26 KR KR1020137022590A patent/KR20140014152A/ko not_active Withdrawn
- 2012-01-26 CN CN201280006419.7A patent/CN103328451B/zh not_active Expired - Fee Related
- 2012-01-26 EP EP12704954.2A patent/EP2668168B1/en not_active Not-in-force
- 2012-01-26 AU AU2012211301A patent/AU2012211301B2/en not_active Ceased
- 2012-01-26 CA CA2825906A patent/CA2825906A1/en not_active Abandoned
- 2012-01-27 AR ARP120100283A patent/AR084944A1/es not_active Application Discontinuation
-
2013
- 2013-05-30 IL IL226677A patent/IL226677A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP5908499B2 (ja) | 2016-04-26 |
| JP2014503590A (ja) | 2014-02-13 |
| AU2012211301B2 (en) | 2016-02-25 |
| US20130030011A1 (en) | 2013-01-31 |
| EP2668168B1 (en) | 2017-03-01 |
| CN103328451A (zh) | 2013-09-25 |
| WO2012103297A1 (en) | 2012-08-02 |
| AR084944A1 (es) | 2013-07-10 |
| AU2012211301A1 (en) | 2013-09-19 |
| SG191840A1 (en) | 2013-08-30 |
| KR20140014152A (ko) | 2014-02-05 |
| CN103328451B (zh) | 2015-06-10 |
| EP2668168A1 (en) | 2013-12-04 |
| US8710061B2 (en) | 2014-04-29 |
| MX2013008699A (es) | 2013-08-21 |
| EA201391097A1 (ru) | 2013-11-29 |
| TW201309655A (zh) | 2013-03-01 |
| CA2825906A1 (en) | 2012-08-02 |
| IL226677A (en) | 2014-11-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112013018298A2 (pt) | compostos para a redução da produção de beta-amiloides | |
| BR112013000920A2 (pt) | compostos para a redução de produção de beta-amiloide | |
| BR112015014253A2 (pt) | produtos de higiene bucal que compreendem um complexo de haleto de aminoácido e zinco tetrabásico | |
| CY1120805T1 (el) | Κρυσταλλικες μορφες αναστολεα προλυλο υδροξυλασης | |
| MY156274A (en) | COMPOUNDS FOR THE REDUCTION OF ß-AMYLOID PRODUCTION | |
| CR20120215A (es) | Anticuerpos contra csf-1r humano y usos de los mismos | |
| BRPI0908421B8 (pt) | solução estável de um composto farmacêutico | |
| MX369388B (es) | Moduladores heterociclicos de sintesis lipidica. | |
| PH12012501390A1 (en) | Fatty acid fumarate derivatives and their uses | |
| UA110054C2 (uk) | Розгалужені похідні 3-фенілпропіонової кислоти і їх застосування | |
| BR112013020513A2 (pt) | adoçante stevia altamente solúvel | |
| UY33863A (es) | Metodos y medicamentos para el tratamiento de la enfermedad de alzheimer | |
| EA201201661A1 (ru) | Новые аминопиразолохиназолины | |
| EA201690520A1 (ru) | Способ получения замещенных 5-фтор-1h-пиразолопиридинов | |
| BR112012028291A2 (pt) | composições farmacêuticas e métodos para sua produção | |
| NI201400022A (es) | Composición farmacéutica que comprende un ciclopolisacárido | |
| BR112013000776A2 (pt) | método e formulação para tratamento de deficiência de ácido siálico | |
| BR112013029730A2 (pt) | composição farmacêutica de rosuvastatina cálcica | |
| BR112014005935A2 (pt) | derivados de anilina, sua preparação e sua aplicação terapêutica | |
| MX340928B (es) | Derivados de oxazolina e isoxazolina como moduladores de canales de calcio de liberación activa (crac). | |
| BR112013030264A2 (pt) | ácidos acéticos de benzociclohepteno | |
| SG10201900541QA (en) | Derivatives of xanthone compounds | |
| BR112014008401A2 (pt) | processo para a preparação de metoxi melonal | |
| GEP20146183B (en) | Process for preparation of l-arginine salt of perindopril | |
| TR201905218T4 (tr) | Nörodejenerati̇f hastaliklarin tedavi̇si̇ i̇çi̇n yararli vi̇tanoli̇dler. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2447 DE 28-11-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |