BR112013014735A2 - captura de radionuclídeos em composições de nanopartículas - Google Patents
captura de radionuclídeos em composições de nanopartículasInfo
- Publication number
- BR112013014735A2 BR112013014735A2 BR112013014735A BR112013014735A BR112013014735A2 BR 112013014735 A2 BR112013014735 A2 BR 112013014735A2 BR 112013014735 A BR112013014735 A BR 112013014735A BR 112013014735 A BR112013014735 A BR 112013014735A BR 112013014735 A2 BR112013014735 A2 BR 112013014735A2
- Authority
- BR
- Brazil
- Prior art keywords
- nanoparticle compositions
- radionuclide capture
- radionuclide
- capture
- nanoparticle
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000002105 nanoparticle Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
- A61K51/1234—Liposomes
- A61K51/1237—Polymersomes, i.e. liposomes with polymerisable or polymerized bilayer-forming substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1203—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules in a form not provided for by groups A61K51/1206 - A61K51/1296, e.g. cells, cell fragments, viruses, virus capsides, ghosts, red blood cells, viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
- A61K51/1234—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0408—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nuclear Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201070542 | 2010-12-14 | ||
| US201161434070P | 2011-01-19 | 2011-01-19 | |
| EP11151372 | 2011-01-19 | ||
| PCT/DK2011/050479 WO2012079582A1 (en) | 2010-12-14 | 2011-12-14 | Entrapment of radionuclides in nanoparticle compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013014735A2 true BR112013014735A2 (pt) | 2016-10-04 |
Family
ID=45445682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013014735A BR112013014735A2 (pt) | 2010-12-14 | 2011-12-14 | captura de radionuclídeos em composições de nanopartículas |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9226984B2 (https=) |
| EP (1) | EP2651447B1 (https=) |
| JP (1) | JP5947807B2 (https=) |
| KR (1) | KR20140092226A (https=) |
| AU (1) | AU2011344865B2 (https=) |
| BR (1) | BR112013014735A2 (https=) |
| CA (1) | CA2821024A1 (https=) |
| DK (1) | DK2651447T3 (https=) |
| RU (1) | RU2013132610A (https=) |
| WO (1) | WO2012079582A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2013249307B2 (en) | 2012-04-17 | 2017-11-09 | Merrimack Pharmaceuticals, Inc. | Compositions and methods for non-invasive imaging |
| US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
| AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
| US9993427B2 (en) * | 2013-03-14 | 2018-06-12 | Biorest Ltd. | Liposome formulation and manufacture |
| WO2015061592A1 (en) * | 2013-10-23 | 2015-04-30 | Merrimack Pharmaceuticals, Inc. | Liposomes for non-invasive imaging and drug delivery |
| TW201615229A (zh) * | 2014-10-23 | 2016-05-01 | 行政院原子能委員會核能研究所 | 製備放射標靶藥物的套件及放射標靶藥物之製造方法 |
| AU2016256979B2 (en) | 2015-05-04 | 2021-01-28 | Genfit | Method for preparing transmembrane pH-gradient vesicles |
| US11318131B2 (en) | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
| EP3337467B1 (en) | 2015-08-20 | 2020-12-09 | Ipsen Biopharm Ltd. | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
| MX385425B (es) | 2015-08-21 | 2025-03-18 | Ipsen Biopharm Ltd | Irinotecán liposomal y oxaliplatino, 5-fluoroacilo y leucovorina para usarse en el tratamiento de cáncer pancreático metastásico. |
| RU2599462C1 (ru) * | 2015-09-22 | 2016-10-10 | Общество с ограниченной ответственностью "БИОТЕХНОЛОГИЯ" (ООО "БИОТЕХНОЛОГИЯ") | Способ полисигнальной активации апоптоза клеток злокачественных солидных опухолей |
| MX382522B (es) | 2015-10-16 | 2025-03-13 | Ipsen Biopharm Ltd | Composiciones farmaceuticas estabilizantes de camptotecina. |
| EP3354270A4 (en) * | 2016-10-21 | 2019-04-24 | Obshestvo S Ogranichennoi Otvetstvennost'yu "Biotehnologiya" | METHOD FOR ACTIVATION OF APOPTOSIS OF CELLS WITH MULTIPLE SIGNALING OF SOLID MALIGNANT TUMORS |
| EP3535026A1 (en) | 2016-11-02 | 2019-09-11 | Ipsen Biopharm Limited | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
| EP3773996A4 (en) | 2018-03-26 | 2022-03-30 | Triumf | Systems, apparatus and methods for separating actinium, radium, and thorium |
| CN109063231B (zh) * | 2018-06-15 | 2023-06-27 | 中国核电工程有限公司 | 基于GUM导则的核素不确定度对临界系统keff影响的评定方法 |
| EP3917499A4 (en) * | 2019-01-29 | 2022-10-19 | The Johns Hopkins University | Adhesive/adsorption switch on nanoparticles to increase tumor uptake and delay tumor clearance |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| WO2023183559A1 (en) * | 2022-03-24 | 2023-09-28 | The Brigham And Women's Hospital, Inc. | Engineered ionophores for transport of metal ions |
| WO2024258223A1 (ko) * | 2023-06-14 | 2024-12-19 | 주식회사 지티아이바이오사이언스 | 방사성 동위원소를 포함하는 나노입자 조성물을 제조하는 장치 및 이의 제조 방법 |
| FR3156311A1 (fr) * | 2023-12-08 | 2025-06-13 | Aken Medical | Nanoparticules radioactives de type cœur/enveloppe utiles en radiothérapie ciblée |
| FR3156312A1 (fr) * | 2023-12-08 | 2025-06-13 | Aken Medical | Nanoparticules radioactives de type cœur/enveloppes utiles en radiothérapie ciblée |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4310506A (en) | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
| US5077056A (en) | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US5736155A (en) | 1984-08-08 | 1998-04-07 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| US4753788A (en) * | 1985-01-31 | 1988-06-28 | Vestar Research Inc. | Method for preparing small vesicles using microemulsification |
| US5622713A (en) | 1985-09-17 | 1997-04-22 | The Regents Of The University Of California | Method of detoxifying animal suffering from overdose |
| ATE88642T1 (de) | 1987-11-04 | 1993-05-15 | Vestar Inc | Zusammensetzung und verfahren zur anwendung von in liposomen eingeschlossenen verbindungen in der neutroneneinfangtherapie von tumoren. |
| US5258499A (en) | 1988-05-16 | 1993-11-02 | Vestar, Inc. | Liposome targeting using receptor specific ligands |
| US5688488A (en) | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5525232A (en) | 1990-03-02 | 1996-06-11 | The Liposome Company, Inc. | Method for entrapment of cationic species in lemellar vesicles |
| JPH075561B2 (ja) | 1991-12-17 | 1995-01-25 | 工業技術院長 | α−アミノ酸のジアミド誘導体 |
| CA2093381A1 (en) * | 1992-04-07 | 1993-10-08 | Hideyuki Sawahara | Liposome formulation and process for production thereof |
| US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| US6306393B1 (en) * | 1997-03-24 | 2001-10-23 | Immunomedics, Inc. | Immunotherapy of B-cell malignancies using anti-CD22 antibodies |
| US6106858A (en) * | 1997-09-08 | 2000-08-22 | Skyepharma, Inc. | Modulation of drug loading in multivescular liposomes |
| US5945502A (en) | 1997-11-13 | 1999-08-31 | Xerox Corporation | Electroluminescent polymer compositions and processes thereof |
| NO312708B1 (no) | 2000-02-21 | 2002-06-24 | Anticancer Therapeutic Inv Sa | Radioaktive liposomer til terapi |
| WO2003011345A1 (en) * | 2001-07-27 | 2003-02-13 | Targesome, Inc. | Lipid constructs as therapeutic and imaging agents |
| DE60222580T2 (de) | 2001-11-13 | 2008-06-12 | Celator Pharmaceuticals, Inc. | Lipidträgerzusammensetzungen und verfahren zur verbesserten wirkstoffzurückhaltung |
| KR20040091076A (ko) * | 2002-02-26 | 2004-10-27 | 아마토 세이야쿠 가부시키가이샤 | 리포솜에의 금속착체의 봉입방법 |
| EP1603535A4 (en) | 2003-03-18 | 2008-10-15 | Ethicon Inc | AROMATASE HEMMER DIAGNOSIS AND THERAPY |
| EP1616182A4 (en) | 2003-03-18 | 2008-04-16 | Ethicon Inc | ENZYMERSATZ THERAPY WITH 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2 |
| JP2006045132A (ja) * | 2004-08-05 | 2006-02-16 | Konica Minolta Medical & Graphic Inc | リポソーム含有磁気共鳴造影剤 |
| US20060040980A1 (en) | 2004-08-20 | 2006-02-23 | Lind Stuart E | Ionophores as cancer chemotherapeutic agents |
| GB0423565D0 (en) | 2004-10-22 | 2004-11-24 | Algeta As | Formulation |
| ITMI20050328A1 (it) | 2005-03-03 | 2006-09-04 | Univ Degli Studi Milano | Composti peptidomimetrici e preparazione di derivati biologicamente attivi |
| TW200922630A (en) | 2007-09-26 | 2009-06-01 | Nat Health Research Institutes | Liposome compositions useful for tumor imaging and treatment |
| WO2009140215A2 (en) | 2008-05-11 | 2009-11-19 | Geraghty, Erin | Method for treating drug-resistant bacterial and other infections with clioquinol, phanquinone, and related compounds |
| JP5429710B2 (ja) * | 2009-03-30 | 2014-02-26 | 独立行政法人放射線医学総合研究所 | 治療薬剤の標的部位への集積及び放出を追跡可能な治療薬剤含有リポソームおよびその製造方法 |
| CA2768444A1 (en) | 2009-07-17 | 2011-01-20 | Rigshospitalet | Loading technique for preparing radionuclide and ionophore containing liposomes in which the ionophore is 2-hydroxyquionoline (carbostyril) or structurally related 2-hydroxyquinolines |
-
2011
- 2011-12-14 KR KR1020137017922A patent/KR20140092226A/ko not_active Withdrawn
- 2011-12-14 DK DK11804942.8T patent/DK2651447T3/en active
- 2011-12-14 US US13/992,080 patent/US9226984B2/en not_active Expired - Fee Related
- 2011-12-14 BR BR112013014735A patent/BR112013014735A2/pt not_active IP Right Cessation
- 2011-12-14 CA CA2821024A patent/CA2821024A1/en not_active Abandoned
- 2011-12-14 WO PCT/DK2011/050479 patent/WO2012079582A1/en not_active Ceased
- 2011-12-14 RU RU2013132610/15A patent/RU2013132610A/ru not_active Application Discontinuation
- 2011-12-14 EP EP11804942.8A patent/EP2651447B1/en not_active Not-in-force
- 2011-12-14 JP JP2013543530A patent/JP5947807B2/ja not_active Expired - Fee Related
- 2011-12-14 AU AU2011344865A patent/AU2011344865B2/en not_active Ceased
-
2015
- 2015-12-14 US US14/968,019 patent/US20160158392A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014506240A (ja) | 2014-03-13 |
| DK2651447T3 (en) | 2018-12-17 |
| EP2651447B1 (en) | 2018-08-29 |
| US9226984B2 (en) | 2016-01-05 |
| AU2011344865B2 (en) | 2017-03-09 |
| EP2651447A1 (en) | 2013-10-23 |
| RU2013132610A (ru) | 2015-01-20 |
| JP5947807B2 (ja) | 2016-07-06 |
| CA2821024A1 (en) | 2012-06-21 |
| KR20140092226A (ko) | 2014-07-23 |
| US20160158392A1 (en) | 2016-06-09 |
| WO2012079582A1 (en) | 2012-06-21 |
| AU2011344865A1 (en) | 2013-07-11 |
| US20130251630A1 (en) | 2013-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2544 DE 08-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |