BR112013008362A2 - combinações - Google Patents
combinaçõesInfo
- Publication number
- BR112013008362A2 BR112013008362A2 BR112013008362A BR112013008362A BR112013008362A2 BR 112013008362 A2 BR112013008362 A2 BR 112013008362A2 BR 112013008362 A BR112013008362 A BR 112013008362A BR 112013008362 A BR112013008362 A BR 112013008362A BR 112013008362 A2 BR112013008362 A2 BR 112013008362A2
- Authority
- BR
- Brazil
- Prior art keywords
- agonist
- inhibitor
- receptor
- combinations
- antagonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
combinações. a invenção refere-se a um produto farmacêutico que compreende, em combinação, (1) um denominado agonista e receptor de glicorticosteroide e (2) um agonista de adrenorreceptor <225>2, um agonista duplo de adrenorreceptor <225>2/antagonista do receptor m3, um antagonista muscarínico, um inibidor da p38 quinase, um inibidor da elastase do neutrófilo, um inibidor da fosfodiesterase pde4, um inibidor de ikk2 quinase ou um agonista do receptor de glicorticoide não esteroidal e o uso do dito produto no tratamento de doenças respiratórias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1016912.6A GB201016912D0 (en) | 2010-10-07 | 2010-10-07 | Novel combination |
PCT/GB2011/051898 WO2012046050A1 (en) | 2010-10-07 | 2011-10-05 | Novel combinations |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013008362A2 true BR112013008362A2 (pt) | 2016-06-14 |
Family
ID=43304217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013008362A BR112013008362A2 (pt) | 2010-10-07 | 2011-10-05 | combinações |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP2624838A1 (pt) |
JP (1) | JP2013538867A (pt) |
KR (1) | KR20130126595A (pt) |
CN (1) | CN103249418A (pt) |
AU (1) | AU2011311310A1 (pt) |
BR (1) | BR112013008362A2 (pt) |
CA (1) | CA2813684A1 (pt) |
GB (1) | GB201016912D0 (pt) |
IL (1) | IL225312A0 (pt) |
IN (1) | IN2013MN00567A (pt) |
MX (1) | MX2013003816A (pt) |
RU (1) | RU2013115103A (pt) |
SG (1) | SG188575A1 (pt) |
WO (1) | WO2012046050A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150027922A (ko) * | 2013-09-04 | 2015-03-13 | 주식회사 대웅제약 | 신규한 항진균성 피리디닐하이드라자이드 유도체 |
KR101657678B1 (ko) * | 2013-11-05 | 2016-09-20 | 주식회사 대웅제약 | 신규한 화합물, 이의 제조방법 및 이를 포함하는 항진균제 조성물 |
PL3377500T3 (pl) * | 2015-11-16 | 2023-01-23 | Esteve Pharmaceuticals, S.A. | Związki oksadiazaspiro do leczenia nadużywania i uzależnienia od narkotyków/leków |
WO2018059537A1 (zh) * | 2016-09-30 | 2018-04-05 | 四川海思科制药有限公司 | 一种二氮杂螺[5.5]十一碳烷衍生物及其用途 |
Family Cites Families (54)
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GB8334494D0 (en) | 1983-12-24 | 1984-02-01 | Tanabe Seiyaku Co | Carbostyril derivatives |
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
GB0103630D0 (en) | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
DE60224172T2 (de) | 2001-03-22 | 2008-12-04 | Glaxo Group Ltd., Greenford | Formanilid-derivative als beta2-adrenorezeptor-agonisten |
SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102617D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
CA2458534C (en) | 2001-09-14 | 2011-11-01 | Glaxo Group Limited | Phenethanolamine derivatives for treatment of respiratory diseases |
TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
AR040661A1 (es) | 2002-07-26 | 2005-04-13 | Theravance Inc | Diclorhidrato cristalino de n-{2-[-((r)-2-hidroxi-2-feniletilamino)fenil]etil}-(r)-2hidroxi-2-(3-formamido-4-hidroxifenil)etilamina, agonista del receptor adrenergico beta 2 |
WO2004032921A1 (en) | 2002-10-11 | 2004-04-22 | Pfizer Limited | Indole derivatives as beta-2 agonists |
EP1556342B1 (en) | 2002-10-28 | 2008-03-26 | Glaxo Group Limited | Phenethanolamine derivative for the treatment of respiratory diseases |
SE0300091D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300092D0 (sv) | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
EP1615881A2 (en) | 2003-04-01 | 2006-01-18 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
ES2329133T3 (es) | 2003-05-28 | 2009-11-23 | Theravance, Inc. | Compuestos azabicicloalcanicos como antagonistas de receptores de muscarinicos. |
TW200526547A (en) | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
EP1685118B1 (en) | 2003-11-21 | 2009-07-08 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
GB0402797D0 (en) | 2004-02-09 | 2004-03-10 | Novartis Ag | Organic compounds |
US7745621B2 (en) | 2004-05-14 | 2010-06-29 | Boehringer Ingelheim International Gmbh | Long acting bronchodilators for the treatment of respiratory diseases |
DE102004024453A1 (de) | 2004-05-14 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen |
EP1751086A2 (en) | 2004-06-03 | 2007-02-14 | Theravance, Inc. | DIAMINE ß2 ADRENERGIC RECEPTOR AGONISTS |
US20060002967A1 (en) | 2004-07-01 | 2006-01-05 | Smestad Thomas L | Resorbable implant with lubricious coating |
JP2008510015A (ja) | 2004-08-16 | 2008-04-03 | セラヴァンス, インコーポレーテッド | β2アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
EP1778626A1 (en) | 2004-08-16 | 2007-05-02 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
GB0425057D0 (en) | 2004-11-12 | 2004-12-15 | Pfizer Ltd | L-tartrate salt of N-1-adamantyl-2-{3-[(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]eth yl}amino)propyl]phenyl}acetamide |
US20060114254A1 (en) | 2004-11-26 | 2006-06-01 | Tim Day | Volume rendering apparatus and method |
WO2006066907A1 (en) | 2004-12-21 | 2006-06-29 | Glaxo Group Limited | Pharmaceutical formulations |
ES2265276B1 (es) | 2005-05-20 | 2008-02-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
GB0512246D0 (en) | 2005-06-15 | 2005-07-27 | Glaxo Group Ltd | Novel pharmaceutical |
AP2402A (en) | 2006-03-20 | 2012-04-30 | Pfizer Ltd | Amine derivatives. |
ES2296516B1 (es) | 2006-04-27 | 2009-04-01 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
TW200808771A (en) | 2006-05-08 | 2008-02-16 | Astrazeneca Ab | Novel compounds II |
GB0613154D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
ATE505193T1 (de) | 2006-08-07 | 2011-04-15 | Boehringer Ingelheim Int | Arzneimittelkombinationen zur behandlung von atemwegserkrankungen |
UY30552A1 (es) | 2006-08-22 | 2008-03-31 | Boehringer Ingelheim Int | Combinaciones farmacologiicas en base a derivados sustituidos de la n-(5-{2-[1,1-dimetil-propilamino]-1-hidroxi-metil}-2-hidroxi-fenil)-metansulfonamida y aplicaciones |
EA200900337A1 (ru) | 2006-10-04 | 2009-10-30 | Пфайзер Лимитед | Сульфонамидные производные в качестве адренергических агонистов и мускариновых антагонистов |
ES2302447B1 (es) | 2006-10-20 | 2009-06-12 | Laboratorios Almirall S.A. | Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico. |
TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
SA08280783B1 (ar) | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
GB0702457D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination 666 |
ES2306595B1 (es) | 2007-02-09 | 2009-09-11 | Laboratorios Almirall S.A. | Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2. |
WO2008106016A2 (en) | 2007-02-27 | 2008-09-04 | Metrosol, Inc. | Prism spectrometer with moveable detector element and with collimated input light |
GB0703999D0 (en) | 2007-03-01 | 2007-04-11 | Astrazeneca Ab | New combination 667 |
SG182958A1 (en) | 2007-06-27 | 2012-08-30 | Astrazeneca Ab | Pyrazinone derivatives and their use in the treatment of lung diseases |
CN101883778A (zh) * | 2007-10-04 | 2010-11-10 | 阿斯利康(瑞典)有限公司 | 具有糖皮质激素活性的甾类[3,2-c]吡唑化合物 |
CA2713322C (en) | 2008-02-06 | 2017-01-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and their use in the treatment of pulmonary disorders |
WO2009138707A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Quinuclidine derivatives as muscarinic m3 receptor antagonists |
CN102908624A (zh) | 2008-05-13 | 2013-02-06 | 阿斯利康(瑞典)有限公司 | 包含毒蕈碱性受体拮抗剂和β2-肾上腺素受体激动剂的药物产品 |
UY32520A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
-
2010
- 2010-10-07 GB GBGB1016912.6A patent/GB201016912D0/en not_active Ceased
-
2011
- 2011-10-05 CA CA2813684A patent/CA2813684A1/en not_active Abandoned
- 2011-10-05 AU AU2011311310A patent/AU2011311310A1/en not_active Abandoned
- 2011-10-05 CN CN2011800589330A patent/CN103249418A/zh active Pending
- 2011-10-05 IN IN567MUN2013 patent/IN2013MN00567A/en unknown
- 2011-10-05 EP EP11781829.4A patent/EP2624838A1/en not_active Withdrawn
- 2011-10-05 JP JP2013532266A patent/JP2013538867A/ja active Pending
- 2011-10-05 WO PCT/GB2011/051898 patent/WO2012046050A1/en active Application Filing
- 2011-10-05 KR KR1020137008725A patent/KR20130126595A/ko not_active Application Discontinuation
- 2011-10-05 RU RU2013115103/15A patent/RU2013115103A/ru not_active Application Discontinuation
- 2011-10-05 SG SG2013019666A patent/SG188575A1/en unknown
- 2011-10-05 MX MX2013003816A patent/MX2013003816A/es unknown
- 2011-10-05 BR BR112013008362A patent/BR112013008362A2/pt not_active Application Discontinuation
-
2013
- 2013-03-18 IL IL225312A patent/IL225312A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN103249418A (zh) | 2013-08-14 |
IL225312A0 (en) | 2013-06-27 |
MX2013003816A (es) | 2013-05-01 |
IN2013MN00567A (pt) | 2015-10-09 |
JP2013538867A (ja) | 2013-10-17 |
AU2011311310A1 (en) | 2013-04-11 |
EP2624838A1 (en) | 2013-08-14 |
KR20130126595A (ko) | 2013-11-20 |
RU2013115103A (ru) | 2014-11-20 |
SG188575A1 (en) | 2013-04-30 |
WO2012046050A1 (en) | 2012-04-12 |
GB201016912D0 (en) | 2010-11-24 |
CA2813684A1 (en) | 2012-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 3A E 4A ANUIDADES. |
|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |